(Z)-RG-13022
(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells.
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- CAS No.: 149286-90-8
- 화학식: C16H14N2O2
- 분자량:266.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
(Z)-RG-13022 (1-100 μM, 24 h) inhibits the DNA synthesis in the HN5 cells dose-dependently and doesn't affect the cell viability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 149286-90-8
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분자량 266.29
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화학식 C16H14N2O2
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SMILES
N#C/C(C1=CN=CC=C1)=C\C2=CC(OC)=C(C=C2)OC
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Synonyms
(Z)-Tyrphostin RG13022
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52(13):3636-41. [Content Brief]
[2]. McLeod HL, et al. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. Br J Cancer. 1996 Dec;74(11):1714-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Z)-RG-13022 Related Classifications
HY-117523 Related Classifications
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