1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. IGF-1R
    Autophagy

AG1024 (Synonyms: Tyrphostin AG 1024)

Cat. No.: HY-10253 Purity: 99.47%
Data Sheet SDS Handling Instructions

AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.

For research use only. We do not sell to patients.
AG1024 Chemical Structure

AG1024 Chemical Structure

CAS No. : 65678-07-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $75 In-stock
5 mg $68 In-stock
10 mg $116 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

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  • References

Description

AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM. IC50 value: 7 uM (IGF-1R autophosphorylation); 57 uM (IR) [1] Target: IGF-1R; IR in vitro: AG-1024 blocks the IGF-1 receptor and IR autophosphorylation with IC50 of 7 μM and 57 μM, respectively. AG-1024 also inhibits the receptor tyrosine kinase activity towards exogenous substrates (TKA) with IC50 values of 18 μM and 80 μM, respectively [1]. Human breast cancer cell line MCF-7 exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Examination of Tyrphostin AG 1024 effects on radiation response demonstrated a marked enhancement in radiosensitivity and amplification of radiation-induced apoptosis [2]. AG-1024 significantly inhibits melanoma cell proliferation with an IC50 of <50 nM in the absence of serum, by blocking MAPK/ERK2 signaling, subsequently rapidly inducing pRb dephosphorylation and activation, and eventually the formation of growth suppressive pRb-E2F complexes [3]. in vivo: Administration of AG-1024 at a dose of 30 μg for 10 days significantly inhibits the tumor growth of Ba/F3-p210 xenograft in mice [4].

References
Molecular Weight

305.17

Formula

C₁₄H₁₃BrN₂O

CAS No.

65678-07-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AG1024
Cat. No.:
HY-10253
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