1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. IGF-1R
    Insulin Receptor
    Apoptosis
  3. AG1024

AG1024 (Synonyms: Tyrphostin AG 1024)

Cat. No.: HY-10253 Purity: 97.16%
Handling Instructions

AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity.

For research use only. We do not sell to patients.

AG1024 Chemical Structure

AG1024 Chemical Structure

CAS No. : 65678-07-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE AG1024

    AG1024 purchased from MCE. Usage Cited in: Biomed Pharmacother. 2017 Nov;95:1346-1358.

    Early and late administration of AG1024 groups (C and E) shows marked collagen deposition within the granuloma compared to early and late administration of PZQ (D and F).
    • Biological Activity

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    Description

    AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity[1][2].

    IC50 & Target

    IC50: 7 μM (IGF1R) and 57 μM (IR)[1][2]

    In Vitro

    AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation[1].
    AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis[1].
    AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: UT7-9 and Baf3-p210 cells
    Concentration: 2, 5, 10 μM
    Incubation Time: 1, 3, 5 days
    Result: Showed a dose-dependent inhibition of cell proliferation.

    Apoptosis Analysis[1]

    Cell Line: UT7-9 and Baf3-p210 cells
    Concentration: 1, 3, 5 μM
    Incubation Time: 1, 2, 3 days
    Result: Induced apoptosis.

    Western Blot Analysis[1]

    Cell Line: UT7-9 and Ba/F3-p210 cells
    Concentration: 2 μM
    Incubation Time: 6, 12 hours
    Result: Downregulated phospho-Akt, Bcr-Abl and upregulated DNA-PKcs.
    In Vivo

    AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female nude mice (6-8 weeks old)[1]
    Dosage: 30 μg
    Administration: IP; per day; for 2 weeks
    Result: Significantly delayed the tumour growth.
    Molecular Weight

    305.17

    Formula

    C₁₄H₁₃BrN₂O

    CAS No.

    65678-07-1

    SMILES

    N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (163.84 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2769 mL 16.3843 mL 32.7686 mL
    5 mM 0.6554 mL 3.2769 mL 6.5537 mL
    10 mM 0.3277 mL 1.6384 mL 3.2769 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    AG1024Tyrphostin AG 1024AG 1024AG-1024Tyrphostin AG1024Tyrphostin AG-1024IGF-1RInsulin ReceptorApoptosisInsulin-like growth factor-1 receptorgrowthfactor-1phosphorylationIGF1Ranti-cancerAktBCR-ABLDNA-PKcsInhibitorinhibitorinhibit

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    Product Name:
    AG1024
    Cat. No.:
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