2. Immunology/Inflammation NF-κB PI3K/Akt/mTOR Epigenetics Neuronal Signaling Membrane Transporter/Ion Channel
  3. NF-κB NO Synthase Akt AMPK Calcium Channel
  4. Syringaresinol

Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of AMPK, eNOS, and intracellular Ca2+ levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM)-induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA).

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Syringaresinol

Syringaresinol 화학구조

CAS No. : 487-35-4

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Other Forms of Syringaresinol:

Syringaresinol Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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nNOS iNOS eNOS

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Akt Akt1 Akt2 Akt3

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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제품 설명

Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of AMPK, eNOS, and intracellular Ca2+ levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM)-induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA)[1][2].

In Vitro

Syringaresinol (0-100 μM, 2 h pretreatment) dose-dependently decreases the production of inflammatory mediators (PGE2, IL-6, TNF-α, NO) and downregulates the protein expression of iNOS and COX-2 in IL-1β-activated mouse chondrocytes[1].
Syringaresinol (0-100 μM, 2 h pretreatment) upregulates the production of ECM components and downregulates the secretion of ECM-degrading enzymes in IL-1β-activated mouse chondrocytes[1].
Syringaresinol (0-100 μM, 2 h pretreatment) inhibits the activation of the NF-κB and AKT signaling pathway[1].
Syringaresinol (10-30 μM, 30 min) dose-dependently increases phosphorylation of Akt, AMPK, and eNOS, and increases intracellular Ca2+ levels in HUVECs[2].
Syringaresinol (30 μM, 30 min) significantly increases eNOS dimerization and decreases eNOS monomer in HUVECs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Syringaresinol Related Antibodies

ELISA Assay[1]

Cell Line: IL-1β-activated mouse chondrocytes
Concentration: 0, 25, 50, 100 μM
Incubation Time: 2 h pretreatment
Result: Reduced the the production of inflammatory mediators (PGE2, IL-6, TNF-α).
Upregulated the production of ECM components (collagen II, aggrecan).
Downregulated the secretion of ECM-degrading enzymes (MMP-13, ADAMTS-5).

Western Blot Analysis[1]

Cell Line: IL-1β-activated mouse chondrocytes
Concentration: 0, 25, 50, 100 μM
Incubation Time: 2 h pretreatment
Result: Downregulated the protein expression of iNOS and COX-2.
Suppressed IL-1β-induced degradation of IκB-α, phosphorylation of p65, and nuclear translocation of p65.
Decreased IL-1β-induced phosphorylation of AKT.
In Vivo

Syringaresinol (10 mg/kg, intra-articular injection, once weekly for 4 consecutive weeks) attenuates osteoarthritis progression in mice with DMM-induced osteoarthritis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 60-day-old male C57BL/6 mice with DMM-induced osteoarthritis[1]
Dosage: 10 mg/kg
Administration: Intra-articular injection, once weekly for 4 consecutive weeks
Result: Reduced joint space narrowing, osteophyte formation and cartilage calcification (X-ray detection).
Alleviated cartilage erosion and proteoglycan depletion.
Reversed the elevation of Osteoarthritis Research Society International (OARSI) scores.
Decreased COX-2 protein expression in cartilage tissue.
분자량

418.44

화학식

C22H26O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(OC)C=C(C2OCC3C2COC3C4=CC(OC)=C(O)C(OC)=C4)C=C1OC
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도
In Vitro: 

DMSO : 50 mg/mL (119.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3898 mL 11.9491 mL 23.8983 mL
5 mM 0.4780 mL 2.3898 mL 4.7797 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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순도&문서

Purity: 99.66%

SDS (393 KB)

COA (257 KB) HNMR (109 KB) RP-HPLC (129 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3898 mL 11.9491 mL 23.8983 mL 59.7457 mL
5 mM 0.4780 mL 2.3898 mL 4.7797 mL 11.9491 mL
10 mM 0.2390 mL 1.1949 mL 2.3898 mL 5.9746 mL
15 mM 0.1593 mL 0.7966 mL 1.5932 mL 3.9830 mL
20 mM 0.1195 mL 0.5975 mL 1.1949 mL 2.9873 mL
25 mM 0.0956 mL 0.4780 mL 0.9559 mL 2.3898 mL
30 mM 0.0797 mL 0.3983 mL 0.7966 mL 1.9915 mL
40 mM 0.0597 mL 0.2987 mL 0.5975 mL 1.4936 mL
50 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1949 mL
60 mM 0.0398 mL 0.1992 mL 0.3983 mL 0.9958 mL
80 mM 0.0299 mL 0.1494 mL 0.2987 mL 0.7468 mL
100 mM 0.0239 mL 0.1195 mL 0.2390 mL 0.5975 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syringaresinol487-35-4NF-κBNO SynthaseAktAMPKCalcium ChannelNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSPKBProtein kinase BAMP-activated protein kinaseCa2+ channelsCa channelsAnti-inflammatoryNODracaena cambodianavasorelaxationInhibitorinhibitorinhibit

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상품명:
Syringaresinol
Cat. No.:
HY-N8307
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