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  3. Genetically Engineered Disease Models Estrogen Receptor/ERR HSP Autophagy Apoptosis
  4. Tamoxifen

Tamoxifen  (Synonyms: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen)

Cat. No.: HY-13757A Pureté: 99.96%
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Tamoxifen

Tamoxifène (ICI 47699) est un modulateur sélectif des récepteurs des œstrogènes (SERM) qui bloque l'action des œstrogènes dans les cellules du sein et peut activer l'activité des œstrogènes dans d'autres cellules, comme les os, le foie, et les cellules utérines. Tamoxifène est un puissant activateur de Hsp90 et améliore l'activité d'ATPase du chaperon moléculaire Hsp90. Tamoxifène active l'autophagie et induit l'apoptosis.

Tamoxifen (ICI 47699) ist ein selektiver estrogen receptor-Modulator (SERM), der die Östrogenwirkung in Brustzellen blockiert und die Östrogenaktivität in anderen Zellen, wie Knochen-, Leber- und Gebärmutterzellen, aktivieren kann. Tamoxifen ist ein potenter Hsp90-Aktivator und steigert die Aktivität des molekularen Hsp90-Chaperons ATPase. Tamoxifen aktiviert die autophagy und induziert die apoptosis.

Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).

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CAS No. : 10540-29-1

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
100 mg En stock
200 mg (100 mg * 2) En stock
500 mg (100 mg * 5) En stock
1 g (100 mg * 10) En stock
5 g En stock
10 g En stock
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Based on 229 publication(s) in Google Scholar

Other Forms of Tamoxifen:

Tamoxifen Related Antibodies

Top Publications Citing Use of Products

229 Publications Citing Use of MCE Tamoxifen

Flow Cytometry
In Vivo Efficacy Study
Histological Imaging/Staining
IHC
WB
Cell Imaging/Staining

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7.  [Abstract]

    Peripheral blood chimerism (%Cd45.2) in mice engrafted with WT (Cd45.1) and Flt3Frt-ITD (Cd45.2) cells following treatment with Tamoxifen (4 mg/mouse; p.o.) (red) or control (black).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7.  [Abstract]

    Flt3Frt-ITD (red), Dnmt3aLox-R878H-Flt3Frt-ITD (orange), and Npm1Frt-c-Flt3Frt-ITD (green) bone marrow was transplanted into lethally irradiated hosts. Kaplan-Meier survival plot following TAM (4 mg/mouse; p.o.).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7.  [Abstract]

    Bone marrow H&E from either control mice or after 7 days of TAM (4 mg/mouse; p.o.).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Nov 11;42(11):1955-1969.e7.  [Abstract]

    Immunohistochemical staining on bone marrow for Ki67 (left) and phopsho-ERK1/2 (right) for untreated (top) and 7-day TAM (4 mg/mouse; p.o.) treated (bottom) Npm1Lox-C-Flt3GL-ITD mice.

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Dec;26(12):2099-2114.  [Abstract]

    Tamoxifen (2 mg/day; i.p.; for 5 consecutive days) can effectively induce the removal of NAT1 in various tissues, including muscle, white adipose tissue, pancreas, and liver, in adult Nat1fl/fl;UBCcreERT2/+ mice and in Nat1fl/fl;UBCcreERT2/+;Ripk1D138N/D138N mice carrying a RIPK1 allele with an inactivation mutation.

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cancer Res. 2024 Nov 15;84(22):3728-3742.  [Abstract]

    Schematic image of selective YAP1 depletion model on Cd248-CreERT2; Yap1flox/flox mice by using Tamoxifen (120 mg/kg/day; i.p. for 5 d).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102509.

    Expression of TFRC in primary fibroblasts from TFRCflox/flox and TFRC−/− mice was assessed by western blot after 5 days of Tamoxifen intraperitoneal injection and 7 days of waiting.

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Immunity. 2020 Nov 17;53(5):1078-1094.e7.  [Abstract]

    Frequency of TdTomato-labelled cells in TdT-Jchain mice treated with Tamoxifen (mice; 50 mg/kg； oral gavage; for two consecutive days) 14 and 15 days after WNV vaccination was analyzed by flow cytometry 13 days later (28 days after WNV vaccination) and compared to week 1 labeling.

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Aug 29;10(24):10874-10891.  [Abstract]

    Representative fields, intracellular TG contents and secreted TG of female C57BL/6 mice hepatocytes treated with C29, Tamoxifen (20 μM; 36 h), Toremifene and 4-OHT. LDs were labeled with Nile Red (red).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Aug 29;10(24):10874-10891.  [Abstract]

    Representative images of liver tissue (top), sections stained with Oil Red O (bottom) and liver TG levels from Ad-ERRα or Ad-Ctrl-injected female mice treated with TMX (100 mg/kg; p.o. for 5 days).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2020 Jan;10(1):137-150.  [Abstract]

    Different transmission of MAPK8/FoxO signaling pathway in breast cancer cells (MCF-7, T47D, ZR-75, and MDA-MB-231) and liver cells (LO2) exposed to TAM (Tamoxifen).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2019 May 23;17(1):50.  [Abstract]

    Tamoxifen inhibits the growth and metastasis of prostate tumors in vivo. Western blot analysis of the indicated proteins in prostate primary tumors tissues.

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    Description

    Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757)[1][2][3][4][5][6][7].

    IC50 & Target[1][4]

    Estrogen receptor

     

    HSP90

     

    Cellular Effect
    Cell Line Type Value Description References
    518A2 IC50
    7.62 3
    Compound: 2
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    518A2 IC50
    7.62 87
    Compound: 2
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A2058 EC50
    12.5 3
    Compound: TAM
    Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    		[PMID: 31099568]
    A2058 EC50
    12.5 3
    Compound: TAM
    Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    		[PMID: 31099568]
    A253 cell line IC50
    8.92 87
    Compound: 2
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A253 cell line IC50
    8.92 3
    Compound: 2
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    518A2 IC50
    7.62 3
    Compound: 2
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A2780 GI50
    30.3 3
    Compound: 1
    Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    		[PMID: 27128175]
    A2780 GI50
    30.3 3
    Compound: 1
    Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    		[PMID: 27128175]
    A-431 ED50
    7 6
    Compound: TAM
    Cytotoxicity against human A431 cells
    Cytotoxicity against human A431 cells
    		[PMID: 16942038]
    A2780 IC50
    7.77 3
    Compound: 2
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A2780 IC50
    7.77 87
    Compound: 2
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A-431 IC50
    > 100 3
    Compound: Tamoxifen
    Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    A-431 ED50
    7 6
    Compound: TAM
    Cytotoxicity against human A431 cells
    Cytotoxicity against human A431 cells
    		[PMID: 16942038]
    A-431 IC50
    > 100 3
    Compound: Tamoxifen
    Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    MCF7 EC50
    0.11 1
    Compound: TAM Z
    Effective dose for [3H]- estradiol against proliferation of MCF-7 cells
    Effective dose for [3H]- estradiol against proliferation of MCF-7 cells
    		[PMID: 2769681]
    A549 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human A549 cells by alamar blue assay
    Cytotoxicity against human A549 cells by alamar blue assay
    		[PMID: 11720540]
    A2058 EC50
    12.5 3
    Compound: TAM
    Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    		[PMID: 31099568]
    A-431 IC50
    >100 3
    Compound: Tamoxifen
    Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    A549 IC50
    10.08 3
    Compound: Tamoxifen
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    A2780 GI50
    30.3 3
    Compound: 1
    Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against human A2780 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    		[PMID: 27128175]
    A549 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human A549 cells by MTT assay
    Antiproliferative activity against human A549 cells by MTT assay
    		[PMID: 31546197]
    A549 GI50
    24.4 3
    Compound: Tamoxifen
    Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    A549 IC50
    17.3 3
    Compound: Tamoxifen
    Anticancer activity against human A549 cells measured after 48 hrs by SRB assay
    Anticancer activity against human A549 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    A549 IC50
    12 3
    Compound: TAM
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    A2780 IC50
    7.77 3
    Compound: 2
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A549 IC50
    12 3
    Compound: TAM
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    A549 IC50
    17.3 3
    Compound: Tamoxifen
    Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    A549 IC50
    10.08 3
    Compound: Tamoxifen
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    A549 IC50
    17.3 3
    Compound: Tamoxifen
    Anticancer activity against human A549 cells measured after 48 hrs by SRB assay
    Anticancer activity against human A549 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    A549 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human A549 cells by MTT assay
    Antiproliferative activity against human A549 cells by MTT assay
    		[PMID: 31546197]
    A549 GI50
    24.4 3
    Compound: Tamoxifen
    Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    A549 GI50
    24.4 3
    Compound: Tamoxifen
    Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human A549 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    A549 IC50
    9.66 87
    Compound: 2
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A549 IC50
    8.4 3
    Compound: Tamoxifen
    Cytotoxicity against human A549 cells assessed as cell viability by MTT assay
    Cytotoxicity against human A549 cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    A549 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human A549 cells by alamar blue assay
    Cytotoxicity against human A549 cells by alamar blue assay
    		[PMID: 11720540]
    A549 IC50
    8.4 3
    Compound: Tamoxifen
    Cytotoxicity against human A549 cells assessed as cell viability by MTT assay
    Cytotoxicity against human A549 cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    A549 IC50
    9.66 3
    Compound: 2
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A549 IC50
    10.08 3
    Compound: Tamoxifen
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    A549 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human A549 cells by MTT assay
    Antiproliferative activity against human A549 cells by MTT assay
    		[PMID: 31546197]
    A549 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human A549 cells by alamar blue assay
    Cytotoxicity against human A549 cells by alamar blue assay
    		[PMID: 11720540]
    Astrocyte IC50
    > 10 3
    Compound: Tamoxifen
    Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method
    Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method
    		[PMID: 26355532]
    A549 IC50
    17.3 3
    Compound: Tamoxifen
    Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    B16-F10 IC50
    64.87 3
    Compound: Tam
    Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay
    Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay
    		[PMID: 25222876]
    A549 IC50
    12 3
    Compound: TAM
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    Astrocyte IC50
    >10 3
    Compound: Tamoxifen
    Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method
    Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method
    		[PMID: 26355532]
    A549 IC50
    17.3 3
    Compound: Tamoxifen
    Anticancer activity against human A549 cells measured after 48 hrs by SRB assay
    Anticancer activity against human A549 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    CHO IC50
    > 100 3
    Compound: Tam
    Antiproliferative activity against CHO cells after 2 days by MTT assay
    Antiproliferative activity against CHO cells after 2 days by MTT assay
    		[PMID: 25222876]
    A549 IC50
    17.3 3
    Compound: Tamoxifen
    Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    DLD-1 IC50
    11.06 3
    Compound: Tamoxifen
    Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay
    Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    B16-F10 IC50
    64.87 3
    Compound: Tam
    Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay
    Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay
    		[PMID: 25222876]
    A549 IC50
    8.4 3
    Compound: Tamoxifen
    Cytotoxicity against human A549 cells assessed as cell viability by MTT assay
    Cytotoxicity against human A549 cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    DLD-1 IC50
    16.3 3
    Compound: Tamoxifen
    Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    DLD-1 IC50
    4.78 3
    Compound: 2
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A549 IC50
    9.66 3
    Compound: 2
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    DU-145 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human DU145 cells by MTT assay
    Antiproliferative activity against human DU145 cells by MTT assay
    		[PMID: 31546197]
    CHO IC50
    >100 3
    Compound: Tam
    Antiproliferative activity against CHO cells after 2 days by MTT assay
    Antiproliferative activity against CHO cells after 2 days by MTT assay
    		[PMID: 25222876]
    DU-145 IC50
    18.07 3
    Compound: Tamoxifen
    Anticancer activity against human DU145 cells measured after 48 hrs by SRB assay
    Anticancer activity against human DU145 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    Astrocyte IC50
    > 10 3
    Compound: Tamoxifen
    Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method
    Cytotoxicity against normal human astrocytes assessed as cell viability incubated for 72 hrs by WST-1 method
    		[PMID: 26355532]
    DLD-1 IC50
    11.06 3
    Compound: Tamoxifen
    Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay
    Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    B16-F10 IC50
    64.87 3
    Compound: Tam
    Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay
    Antiproliferative activity mouse B16F10 cells after 2 days by MTT assay
    		[PMID: 25222876]
    DU-145 GI50
    19.3 3
    Compound: Tamoxifen
    Anti-proliferative activity against human DU145 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human DU145 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    DU-145 IC50
    28.9 3
    Compound: Tamoxifen
    Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    DLD-1 IC50
    4.78 87
    Compound: 2
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    DU-145 IC50
    5.5 3
    Compound: TAM
    Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
    Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    DLD-1 IC50
    16.3 3
    Compound: Tamoxifen
    Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    DU-145 GI50
    6.07 3
    Compound: Tamoxifen
    Anticancer activity against human DU145 cells after 24 hrs by SRB assay
    Anticancer activity against human DU145 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    DU-145 GI50
    6.07 3
    Compound: Tamoxifen
    Anticancer activity against human DU145 cells after 24 hrs by SRB assay
    Anticancer activity against human DU145 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    DU-145 GI50
    19.3 3
    Compound: Tamoxifen
    Anti-proliferative activity against human DU145 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human DU145 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    EKVX GI50
    6.3 3
    Compound: TAM
    Cytotoxicity against human EKVX cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human EKVX cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    FaDu IC50
    5.39 3
    Compound: Tamoxifen
    Anticancer activity against human FADU cells measured after 48 hrs by SRB assay
    Anticancer activity against human FADU cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    DU-145 IC50
    18.07 3
    Compound: Tamoxifen
    Anticancer activity against human DU145 cells measured after 48 hrs by SRB assay
    Anticancer activity against human DU145 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    DU-145 IC50
    5.5 3
    Compound: TAM
    Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
    Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    Fibroblast IC50
    > 20 3
    Compound: TAM
    Antiproliferative activity against mouse fibroblasts after 48 hrs by MTT assay
    Antiproliferative activity against mouse fibroblasts after 48 hrs by MTT assay
    		[PMID: 23287057]
    CHO IC50
    > 100 3
    Compound: Tam
    Antiproliferative activity against CHO cells after 2 days by MTT assay
    Antiproliferative activity against CHO cells after 2 days by MTT assay
    		[PMID: 25222876]
    DU-145 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human DU145 cells by MTT assay
    Antiproliferative activity against human DU145 cells by MTT assay
    		[PMID: 31546197]
    Fibroblast CC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    DU-145 IC50
    28.9 3
    Compound: Tamoxifen
    Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    Fibroblast CC50
    12.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HSF cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against human HSF cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    EKVX GI50
    6.3 3
    Compound: TAM
    Cytotoxicity against human EKVX cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human EKVX cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    HCT-116 IC50
    45 3
    Compound: Tamoxifen
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    HCT-15 GI50
    3.16 3
    Compound: TAM
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    FaDu IC50
    5.39 3
    Compound: Tamoxifen
    Anticancer activity against human FADU cells measured after 48 hrs by SRB assay
    Anticancer activity against human FADU cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    Caco-2 EC50
    56.5 3
    Compound: Tamoxifen
    Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco-2 cells
    Inhibition of P-glycoprotein-mediated [3H]vinblastine transport in human Caco-2 cells
    		[PMID: 18524592]
    Fibroblast CC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    HEK293 IC50
    > 50 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells by MTT assay
    Cytotoxicity against HEK293 cells by MTT assay
    		[PMID: 31546197]
    Fibroblast CC50
    12.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HSF cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against human HSF cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    Caco-2 IC50
    29 3
    Compound: Tamoxifen
    TP_TRANSPORTER: transepithelial transport of Rhodamine 123 (basal to apical) in Caco-2 cells
    TP_TRANSPORTER: transepithelial transport of Rhodamine 123 (basal to apical) in Caco-2 cells
    		[PMID: 15386482]
    HEK293 IC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    Fibroblast IC50
    >20 3
    Compound: TAM
    Antiproliferative activity against mouse fibroblasts after 48 hrs by MTT assay
    Antiproliferative activity against mouse fibroblasts after 48 hrs by MTT assay
    		[PMID: 23287057]
    HEK293 IC50
    10 3
    Compound: Tamoxifen
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay
    		[PMID: 21871812]
    HCT-116 IC50
    45 3
    Compound: Tamoxifen
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    HEK293 CC50
    13 6
    Compound: TAM
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30316060]
    HCT-15 GI50
    3.16 3
    Compound: TAM
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    Cancer cell lines IC50
    10.6 3
    Compound: Tamoxifen
    Antiproliferative activity in MDA-MB 231 human breast cancer cells
    Antiproliferative activity in MDA-MB 231 human breast cancer cells
    		[PMID: 15658875]
    HEK293 CC50
    13.1 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin dye-based fluorescence assay
    Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin dye-based fluorescence assay
    		[PMID: 30901686]
    HEK293 CC50
    13 6
    Compound: TAM
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30316060]
    HEK293 CC50
    13.1 6
    Compound: Tamoxifen
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 20 hrs by resazurin dye-based fluorometric assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 20 hrs by resazurin dye-based fluorometric assay
    		[PMID: 30831407]
    DLD-1 IC50
    11.06 3
    Compound: Tamoxifen
    Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay
    Anticancer activity against human DLD1 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    HEK293 IC50
    20.93 3
    Compound: Tamoxifen
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    HEK293 CC50
    39.4 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30322754]
    HEK293 IC50
    22.4 3
    Compound: TAM
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as cell viability after 20 hrs by fluorescence assay
    Cytotoxicity against HEK293 cells assessed as cell viability after 20 hrs by fluorescence assay
    		[PMID: 33609657]
    DLD-1 IC50
    16.3 3
    Compound: Tamoxifen
    Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    HEK293 CC50
    13.1 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin dye-based fluorescence assay
    Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin dye-based fluorescence assay
    		[PMID: 30901686]
    DLD-1 IC50
    4.78 3
    Compound: 2
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    HEK293 IC50
    24 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 20 hrs by resazurin dye based assay
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 20 hrs by resazurin dye based assay
    		[PMID: 35477062]
    HEK293 CC50
    62 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    		[PMID: 28257200]
    HEK293 IC50
    24 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    		[PMID: 30975502]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    		[PMID: 32619924]
    DU-145 GI50
    19.3 3
    Compound: Tamoxifen
    Anti-proliferative activity against human DU145 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human DU145 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    HEK293 IC50
    26 3
    Compound: TAM
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    HEK293 CC50
    13.1 6
    Compound: Tamoxifen
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 20 hrs by resazurin dye-based fluorometric assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 20 hrs by resazurin dye-based fluorometric assay
    		[PMID: 30831407]
    DU-145 GI50
    6.07 3
    Compound: Tamoxifen
    Anticancer activity against human DU145 cells after 24 hrs by SRB assay
    Anticancer activity against human DU145 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    HEK293 IC50
    26.33 3
    Compound: 1
    Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    DU-145 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human DU145 cells by MTT assay
    Antiproliferative activity against human DU145 cells by MTT assay
    		[PMID: 31546197]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against human HEK-293 cells incubated for 23 hrs by CO-ADD method
    Cytotoxicity against human HEK-293 cells incubated for 23 hrs by CO-ADD method
    		[PMID: 33738069]
    HEK293 CC50
    39.4 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30322754]
    DU-145 IC50
    18.07 3
    Compound: Tamoxifen
    Anticancer activity against human DU145 cells measured after 48 hrs by SRB assay
    Anticancer activity against human DU145 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    HEK293 IC50
    20.93 3
    Compound: Tamoxifen
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    HEK293 IC50
    50 3
    Compound: Tamoxifen
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    HEK293 CC50
    62 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    		[PMID: 28257200]
    DU-145 IC50
    28.9 3
    Compound: Tamoxifen
    Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against ERalpha-deficient human DU145 cells expressing ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    HEK293 IC50
    10 3
    Compound: Tamoxifen
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay
    		[PMID: 21871812]
    MCF7 EC50
    10 1
    Compound: 3 (Tamoxifen)
    Effective concentration against MCF-7 breast tumor cells using MCF-7 assay.
    Effective concentration against MCF-7 breast tumor cells using MCF-7 assay.
    		[PMID: 12825935]
    DU-145 IC50
    5.5 3
    Compound: TAM
    Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
    Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as cell viability after 20 hrs by fluorescence assay
    Cytotoxicity against HEK293 cells assessed as cell viability after 20 hrs by fluorescence assay
    		[PMID: 33609657]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    		[PMID: 32619924]
    HEK293 IC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    HEK293 IC50
    24 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 20 hrs by resazurin dye based assay
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 20 hrs by resazurin dye based assay
    		[PMID: 35477062]
    EKVX GI50
    6.3 3
    Compound: TAM
    Cytotoxicity against human EKVX cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human EKVX cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against human HEK-293 cells incubated for 23 hrs by CO-ADD method
    Cytotoxicity against human HEK-293 cells incubated for 23 hrs by CO-ADD method
    		[PMID: 33738069]
    EL4 IC50
    535 1
    Compound: 1a
    Inhibition of [3H]thymidine incorporation into EL4 cell proliferation
    Inhibition of [3H]thymidine incorporation into EL4 cell proliferation
    		[PMID: 1573630]
    HEK-293T IC50
    0.039 3
    Compound: Tamoxifen
    Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay
    Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay
    		[PMID: 23786452]
    HEK293 IC50
    >50 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells by MTT assay
    Cytotoxicity against HEK293 cells by MTT assay
    		[PMID: 31546197]
    FaDu IC50
    5.39 3
    Compound: Tamoxifen
    Anticancer activity against human FADU cells measured after 48 hrs by SRB assay
    Anticancer activity against human FADU cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    HeLa IC50
    0.341 3
    Compound: Tamoxifen
    Antagonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    Antagonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    		[PMID: 28882502]
    HEK293 IC50
    24 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    		[PMID: 30975502]
    Fibroblast CC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    HEK293 IC50
    26 3
    Compound: TAM
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    HeLa IC50
    0.73 3
    Compound: Tamoxifen
    Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
    Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
    		[PMID: 29624387]
    Fibroblast CC50
    12.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HSF cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against human HSF cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    HeLa IC50
    1.53 3
    Compound: Tamoxifen
    Antagonist activity at full length ERbeta (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    Antagonist activity at full length ERbeta (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    		[PMID: 28882502]
    HEK293 IC50
    50 3
    Compound: Tamoxifen
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    HeLa IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human HeLa cells by MTT assay
    Antiproliferative activity against human HeLa cells by MTT assay
    		[PMID: 31546197]
    HEK293 IC50
    26.33 3
    Compound: 1
    Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    Fibroblast IC50
    > 20 3
    Compound: TAM
    Antiproliferative activity against mouse fibroblasts after 48 hrs by MTT assay
    Antiproliferative activity against mouse fibroblasts after 48 hrs by MTT assay
    		[PMID: 23287057]
    HEK293 IC50
    22.4 3
    Compound: TAM
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    HeLa GI50
    12 3
    Compound: 1
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    		[PMID: 27128175]
    HEK-293T IC50
    0.039 3
    Compound: Tamoxifen
    Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay
    Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay
    		[PMID: 23786452]
    HeLa IC50
    12.5 3
    Compound: Tamoxifen
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    HeLa GI50
    32.6 3
    Compound: 1
    Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    HeLa GI50
    32.6 3
    Compound: 1
    Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    HeLa GI50
    12 3
    Compound: 1
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    		[PMID: 27128175]
    HeLa IC50
    8.85 3
    Compound: Tamoxifen
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28838694]
    HeLa IC50
    0.341 3
    Compound: Tamoxifen
    Antagonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    Antagonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    		[PMID: 28882502]
    Hepatocyte EC50
    34.4 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 24 hrs by ATP detection based assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 24 hrs by ATP detection based assay
    		[PMID: 22531045]
    HeLa IC50
    1.53 3
    Compound: Tamoxifen
    Antagonist activity at full length ERbeta (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    Antagonist activity at full length ERbeta (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    		[PMID: 28882502]
    Hepatocyte EC50
    67.6 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by LDH release assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by LDH release assay
    		[PMID: 22531045]
    HeLa IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human HeLa cells by MTT assay
    Antiproliferative activity against human HeLa cells by MTT assay
    		[PMID: 31546197]
    Hepatocyte EC50
    71.4 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by ATP detection based assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by ATP detection based assay
    		[PMID: 22531045]
    HeLa IC50
    12.5 3
    Compound: Tamoxifen
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    HepG2 IC50
    12 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 30613327]
    HeLa IC50
    8.85 3
    Compound: Tamoxifen
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28838694]
    HepG2 IC50
    19.6 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer 96 aqueous one solution cell proliferation assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer 96 aqueous one solution cell proliferation assay
    		[PMID: 34015704]
    HeLa IC50
    >1 3
    Compound: 6
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor beta; ERE assay
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor beta; ERE assay
    		[PMID: 15658851]
    HepG2 GI50
    21.7 3
    Compound: Tamoxifen
    Anti-proliferative activity against human HepG2 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human HepG2 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    HeLa IC50
    0.73 3
    Compound: Tamoxifen
    Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
    Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
    		[PMID: 29624387]
    HepG2 IC50
    23.4 3
    Compound: tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter-BlueCell viability assay
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter-BlueCell viability assay
    		[PMID: 20545334]
    Hepatocyte EC50
    34.4 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 24 hrs by ATP detection based assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 24 hrs by ATP detection based assay
    		[PMID: 22531045]
    HepG2 CC50
    24.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30322754]
    Hepatocyte EC50
    71.4 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by ATP detection based assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by ATP detection based assay
    		[PMID: 22531045]
    HepG2 EC50
    35 3
    Compound: Tamoxifen
    Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 4 hrs by CellTiter-Glo assay
    Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 4 hrs by CellTiter-Glo assay
    		[PMID: 27652492]
    HCT-116 IC50
    45 3
    Compound: Tamoxifen
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    HepG2 EC50
    35 3
    Compound: Tamoxifen
    Cytotoxicity in human HepG2 cells assessed as induction of cell necrosis incubated for 4 hrs by LDH release assay
    Cytotoxicity in human HepG2 cells assessed as induction of cell necrosis incubated for 4 hrs by LDH release assay
    		[PMID: 27652492]
    Hepatocyte EC50
    67.6 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by LDH release assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by LDH release assay
    		[PMID: 22531045]
    HepG2 CC50
    24.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30322754]
    HepG2 IC50
    6.3 3
    Compound: TAM
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    HepG2 CC50
    62 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    		[PMID: 28257200]
    HepG2 CC50
    62 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    		[PMID: 28257200]
    HCT-15 GI50
    3.16 3
    Compound: TAM
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human HCT15 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    HepG2 EC50
    35 3
    Compound: Tamoxifen
    Cytotoxicity in human HepG2 cells assessed as induction of cell necrosis incubated for 4 hrs by LDH release assay
    Cytotoxicity in human HepG2 cells assessed as induction of cell necrosis incubated for 4 hrs by LDH release assay
    		[PMID: 27652492]
    HEK-293T IC50
    0.039 3
    Compound: Tamoxifen
    Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay
    Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay
    		[PMID: 23786452]
    HL-60 IC50
    14.3 3
    Compound: Tamoxifen
    Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS
    Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS
    		[PMID: 22901895]
    HL-60 IC50
    5.9 6
    Compound: 1, Tamoxifen
    Growth inhibition of human HL60 cells after 4 hrs by MTT assay
    Growth inhibition of human HL60 cells after 4 hrs by MTT assay
    		[PMID: 17904372]
    HepG2 GI50
    21.7 3
    Compound: Tamoxifen
    Anti-proliferative activity against human HepG2 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human HepG2 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    HEK293 CC50
    13.1 6
    Compound: Tamoxifen
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 20 hrs by resazurin dye-based fluorometric assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 20 hrs by resazurin dye-based fluorometric assay
    		[PMID: 30831407]
    HepG2 IC50
    6.3 3
    Compound: TAM
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    HT-29 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human HT-29 cells by alamar blue assay
    Cytotoxicity against human HT-29 cells by alamar blue assay
    		[PMID: 11720540]
    HepG2 IC50
    23.4 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells
    Cytotoxicity against human HepG2 cells
    		[PMID: 32386856]
    HT-29 IC50
    38.6 3
    Compound: tamoxifen
    Cytotoxicity against human HT-29 cells after 24 hrs by CellTiter-BlueCell viability assay
    Cytotoxicity against human HT-29 cells after 24 hrs by CellTiter-BlueCell viability assay
    		[PMID: 20545334]
    HEK293 CC50
    13.1 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin dye-based fluorescence assay
    Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin dye-based fluorescence assay
    		[PMID: 30901686]
    HEK293 CC50
    13 6
    Compound: TAM
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30316060]
    HepG2 IC50
    23.4 3
    Compound: tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter-BlueCell viability assay
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter-BlueCell viability assay
    		[PMID: 20545334]
    Ishikawa IC50
    0.42 3
    Compound: tamoxifen
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 4 days by ELISA
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 4 days by ELISA
    		[PMID: 9784163]
    Ishikawa IC50
    14.58 3
    Compound: Tamoxifen
    Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34509864]
    HEK293 CC50
    39.4 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30322754]
    HepG2 IC50
    12 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 30613327]
    HEK293 CC50
    62 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    		[PMID: 28257200]
    HepG2 IC50
    19.6 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer 96 aqueous one solution cell proliferation assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer 96 aqueous one solution cell proliferation assay
    		[PMID: 34015704]
    Ishikawa IC50
    16.47 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    		[PMID: 28460819]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    		[PMID: 32619924]
    HepG2 IC50
    11.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with galactose by CellTiter-Glo luminescent assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with galactose by CellTiter-Glo luminescent assay
    		[PMID: 37736177]
    Ishikawa IC50
    16.78 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human Ishikawa cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34022716]
    HepG2 IC50
    23.4 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with glucose by CellTiter-Glo luminescent assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with glucose by CellTiter-Glo luminescent assay
    		[PMID: 37736177]
    Ishikawa IC50
    170 1
    Compound: 1a
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 72 hrs
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 72 hrs
    		[PMID: 18835176]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as cell viability after 20 hrs by fluorescence assay
    Cytotoxicity against HEK293 cells assessed as cell viability after 20 hrs by fluorescence assay
    		[PMID: 33609657]
    MCF7 IC50
    20 1
    Compound: 7
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    		[PMID: 33479633]
    Ishikawa IC50
    20.65 3
    Compound: Tamoxifen
    Cytotoxicity in human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity in human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 28942113]
    HEK293 CC50
    9 6
    Compound: Tamoxifen
    Cytotoxicity against human HEK-293 cells incubated for 23 hrs by CO-ADD method
    Cytotoxicity against human HEK-293 cells incubated for 23 hrs by CO-ADD method
    		[PMID: 33738069]
    Ishikawa IC50
    22.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    HL-60 IC50
    14.3 3
    Compound: Tamoxifen
    Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS
    Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS
    		[PMID: 22901895]
    HEK293 IC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against HEK293 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    HL-60 IC50
    5.9 6
    Compound: 1, Tamoxifen
    Growth inhibition of human HL60 cells after 4 hrs by MTT assay
    Growth inhibition of human HL60 cells after 4 hrs by MTT assay
    		[PMID: 17904372]
    HEK293 IC50
    10 3
    Compound: Tamoxifen
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTT assay
    		[PMID: 21871812]
    Ishikawa IC50
    26.52 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    		[PMID: 29587221]
    Ishikawa IC50
    6 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    HEK293 IC50
    20.93 3
    Compound: Tamoxifen
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    HT-29 GI50
    9.5 3
    Compound: Tamoxifen
    Growth inhibition of human HT-29 cells
    Growth inhibition of human HT-29 cells
    		[PMID: 23403084]
    Ishikawa IC50
    7.87 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human Ishikawa cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human Ishikawa cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    HEK293 IC50
    22.4 3
    Compound: TAM
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    HT-29 IC50
    38.6 3
    Compound: tamoxifen
    Cytotoxicity against human HT-29 cells after 24 hrs by CellTiter-BlueCell viability assay
    Cytotoxicity against human HT-29 cells after 24 hrs by CellTiter-BlueCell viability assay
    		[PMID: 20545334]
    HEK293 IC50
    24 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    Cytotoxicity against HEK293 cells measured after 20 hrs by resazurin dye based fluorescence assay
    		[PMID: 30975502]
    J774.A1 CC50
    11.06 3
    Compound: Tamoxifen
    Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability incubated for 24 hrs by neutral red uptake assay
    Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability incubated for 24 hrs by neutral red uptake assay
    		[PMID: 31376569]
    Jurkat IC50
    8.3 3
    Compound: Tamoxifen
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    		[PMID: 23792352]
    HT-29 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human HT-29 cells by alamar blue assay
    Cytotoxicity against human HT-29 cells by alamar blue assay
    		[PMID: 11720540]
    HEK293 IC50
    24 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 20 hrs by resazurin dye based assay
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 20 hrs by resazurin dye based assay
    		[PMID: 35477062]
    HEK293 IC50
    26 3
    Compound: TAM
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    MCF7 IC50
    30 1
    Compound: Tam
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    		[PMID: 33257172]
    K562 GI50
    5.2 3
    Compound: tamoxifen
    Antiproliferative activity against human K562 cells after 72 hrs
    Antiproliferative activity against human K562 cells after 72 hrs
    		[PMID: 25420175]
    HEK293 IC50
    26.33 3
    Compound: 1
    Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    MCF-10A IC50
    > 1000 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    Ishikawa IC50
    0.42 3
    Compound: tamoxifen
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 4 days by ELISA
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 4 days by ELISA
    		[PMID: 9784163]
    HEK293 IC50
    50 3
    Compound: Tamoxifen
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    Ishikawa IC50
    14.58 3
    Compound: Tamoxifen
    Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34509864]
    MCF-10A IC50
    > 1000 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    HEK293 IC50
    > 50 3
    Compound: Tamoxifen
    Cytotoxicity against HEK293 cells by MTT assay
    Cytotoxicity against HEK293 cells by MTT assay
    		[PMID: 31546197]
    Ishikawa IC50
    16.47 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    		[PMID: 28460819]
    MCF-10A IC50
    > 50 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF-10A cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MCF7 IC50
    < 1000 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    Ishikawa IC50
    26.52 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    		[PMID: 29587221]
    Ishikawa IC50
    16.78 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human Ishikawa cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34022716]
    MCF7 EC50
    > 200 1
    Compound: 2
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by Cell-titer Glo assay
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by Cell-titer Glo assay
    		[PMID: 34251202]
    MCF7 IC50
    0.027 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 22472045]
    Ishikawa IC50
    22.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MCF7 IC50
    0.794 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 5 days
    Cytotoxicity against human MCF7 cells after 5 days
    		[PMID: 23864928]
    Ishikawa IC50
    6 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    Ishikawa IC50
    20.65 3
    Compound: Tamoxifen
    Cytotoxicity in human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity in human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 28942113]
    MCF7 IC50
    1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 20451380]
    Ishikawa IC50
    7.87 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human Ishikawa cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human Ishikawa cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    MCF7 IC50
    1.31 6
    Compound: Tamoxifen
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of colony formation measured after 3 weeks by crystal violet staining based soft agar colony formation assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of colony formation measured after 3 weeks by crystal violet staining based soft agar colony formation assay
    		[PMID: 31884407]
    J774.A1 CC50
    11.06 3
    Compound: Tamoxifen
    Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability incubated for 24 hrs by neutral red uptake assay
    Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability incubated for 24 hrs by neutral red uptake assay
    		[PMID: 31376569]
    MCF7 GI50
    1.58 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    Jurkat IC50
    8.3 3
    Compound: Tamoxifen
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    		[PMID: 23792352]
    MCF7 IC50
    1.82 3
    Compound: TAMOX, TAM
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 23123017]
    Ishikawa EC50
    33 1
    Compound: 2
    Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells
    Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells
    		[PMID: 8201587]
    MCF7 IC50
    1.89 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 24721727]
    MCF7 EC50
    10 1
    Compound: 3 (Tamoxifen)
    Effective concentration against MCF-7 breast tumor cells using MCF-7 assay.
    Effective concentration against MCF-7 breast tumor cells using MCF-7 assay.
    		[PMID: 12825935]
    K562 GI50
    5.2 3
    Compound: tamoxifen
    Antiproliferative activity against human K562 cells after 72 hrs
    Antiproliferative activity against human K562 cells after 72 hrs
    		[PMID: 25420175]
    MCF7 IC50
    10 3
    Compound: tamoxifene
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 19423356]
    MCF7 IC50
    10.74 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MCF7 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 31546197]
    HL-60 IC50
    14.3 3
    Compound: Tamoxifen
    Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS
    Cytotoxicity against human HL60 cells after 72 hrs by WST1 assay in presence of 20% FBS
    		[PMID: 22901895]
    HL-60 IC50
    5.9 6
    Compound: 1, Tamoxifen
    Growth inhibition of human HL60 cells after 4 hrs by MTT assay
    Growth inhibition of human HL60 cells after 4 hrs by MTT assay
    		[PMID: 17904372]
    MCF7 IC50
    10.9 3
    Compound: Tamoxifen
    Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    MDA-MB-435 IC50
    50 1
    Compound: Tamoxifen
    Inhibition of MDA-MB-435 breast cancer cell proliferation
    Inhibition of MDA-MB-435 breast cancer cell proliferation
    		[PMID: 14971899]
    MCF7 IC50
    11 3
    Compound: Tamoxifen
    Inhibitory concentration against MCF-7 (ER+) cell line using SRB assay
    Inhibitory concentration against MCF-7 (ER+) cell line using SRB assay
    		[PMID: 12565971]
    MCF-10A IC50
    14.267 3
    Compound: 1; TMX
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    		[PMID: 37484572]
    MCF7 IC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    MCF-10A IC50
    8.263 3
    Compound: 1; TMX
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    		[PMID: 37484572]
    MCF7 IC50
    11.35 3
    Compound: Tamoxifen
    Antiproliferative activity against ER positive human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against ER positive human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 28460819]
    MCF-10A IC50
    15 3
    Compound: 1; TMX
    Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth
    Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth
    		[PMID: 37484572]
    HT-29 GI50
    9.5 3
    Compound: Tamoxifen
    Growth inhibition of human HT-29 cells
    Growth inhibition of human HT-29 cells
    		[PMID: 23403084]
    MCF7 IC50
    11.4 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by WST-1 assay
    Cytotoxicity against human MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    HT-29 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human HT-29 cells by alamar blue assay
    Cytotoxicity against human HT-29 cells by alamar blue assay
    		[PMID: 11720540]
    MCF-10A IC50
    26.8 3
    Compound: TMX
    Cytotoxicity against human MCF-10A assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    Cytotoxicity against human MCF-10A assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    		[PMID: 38020071]
    MCF7 IC50
    11.44 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    MCF-10A IC50
    >50 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF-10A cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MCF7 IC50
    11.55 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    HT-29 IC50
    38.6 3
    Compound: tamoxifen
    Cytotoxicity against human HT-29 cells after 24 hrs by CellTiter-BlueCell viability assay
    Cytotoxicity against human HT-29 cells after 24 hrs by CellTiter-BlueCell viability assay
    		[PMID: 20545334]
    MCF7 IC50
    11.8 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells expressing estrogen receptor by MTT assay
    Anticancer activity against human MCF7 cells expressing estrogen receptor by MTT assay
    		[PMID: 20951035]
    MCF-10A IC50
    >1 2
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MCF7 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells expressing ER
    Cytotoxicity against human MCF7 cells expressing ER
    		[PMID: 16942038]
    MCF7 IC50
    12 3
    Compound: tamoxifen
    Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay
    Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay
    		[PMID: 19446930]
    MCF7 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells expressing estrogen receptor after 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells expressing estrogen receptor after 72 hrs by SRB assay
    		[PMID: 19425534]
    MCF7 GI50
    12 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    MCF7 GI50
    12 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    MCF7 IC50
    12.35 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23830503]
    MCF7 GI50
    8 3
    Compound: Tamoxifen
    Anti-proliferative activity against human MCF7 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human MCF7 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    MCF7 IC50
    12.48 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MCF7 IC50
    12.5 3
    Compound: Tam
    Cytotoxicity against human MCF7 cells expressing ER after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing ER after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 GI50
    6.5 3
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    		[PMID: 27128175]
    MCF7 GI50
    6.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MCF7 IC50
    13.45 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23902804]
    HeLa GI50
    12 3
    Compound: 1
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    		[PMID: 27128175]
    HeLa GI50
    32.6 3
    Compound: 1
    Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    MCF7 GI50
    1.58 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    13.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT reduction assay
    Antiproliferative activity against human MCF7 cells by MTT reduction assay
    		[PMID: 33421712]
    MCF7 GI50
    11.2 3
    Compound: Tamoxifen
    Growth inhibition of estrogen-dependent human MCF7 cells
    Growth inhibition of estrogen-dependent human MCF7 cells
    		[PMID: 23403084]
    HeLa IC50
    0.341 3
    Compound: Tamoxifen
    Antagonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    Antagonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    		[PMID: 28882502]
    MCF7 IC50
    14.35 3
    Compound: Tamoxifen
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 28942113]
    MCF7 GI50
    <10 6
    Compound: Tmx
    Growth inhibition of human MCF7 cells assessed as cell growth inhibition by SRB assay
    Growth inhibition of human MCF7 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 36481599]
    HeLa IC50
    0.73 3
    Compound: Tamoxifen
    Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
    Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
    		[PMID: 29624387]
    MCF7 IC50
    15.2 3
    Compound: 6
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23880359]
    HeLa IC50
    1.53 3
    Compound: Tamoxifen
    Antagonist activity at full length ERbeta (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    Antagonist activity at full length ERbeta (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
    		[PMID: 28882502]
    MCF7 IC50
    12 3
    Compound: tamoxifen
    Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay
    Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay
    		[PMID: 19446930]
    MCF7 IC50
    15.21 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    HeLa IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human HeLa cells by MTT assay
    Antiproliferative activity against human HeLa cells by MTT assay
    		[PMID: 31546197]
    MCF7 IC50
    18.18 3
    Compound: Tamoxifen
    Anticancer activity against human ER-positive MCF7 cells measured after 48 hrs by SRB assay
    Anticancer activity against human ER-positive MCF7 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    MCF7 IC50
    15.46 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29587221]
    MCF7 IC50
    15.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    HeLa IC50
    12.5 3
    Compound: Tamoxifen
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    MCF7 IC50
    3.53 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells
    Anticancer activity against human MCF7 cells
    		[PMID: 31926469]
    MCF7 IC50
    16.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30384047]
    MCF7 IC50
    8.38 6
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells assessed a cell growth inhibition incubated for 48 hrs by SRB assay
    Anticancer activity against human MCF7 cells assessed a cell growth inhibition incubated for 48 hrs by SRB assay
    		[PMID: 32771798]
    HeLa IC50
    622 1
    Compound: 6
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor alpha; ERE assay
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor alpha; ERE assay
    		[PMID: 15658851]
    MCF7 IC50
    20.24 3
    Compound: Tmx
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    		[PMID: 36481599]
    MCF7 IC50
    18.18 3
    Compound: Tamoxifen
    Anticancer activity against human ER-positive MCF7 cells measured after 48 hrs by SRB assay
    Anticancer activity against human ER-positive MCF7 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    HeLa IC50
    8.85 3
    Compound: Tamoxifen
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 28838694]
    MCF7 IC50
    25.787 3
    Compound: 1; TMX
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    		[PMID: 37484572]
    HeLa IC50
    > 1000 1
    Compound: 6
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor beta; ERE assay
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor beta; ERE assay
    		[PMID: 15658851]
    MCF7 IC50
    18.71 3
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
    		[PMID: 25734623]
    MCF7 IC50
    9 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 32731188]
    MCF7 IC50
    19.2 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin based fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin based fluorescence assay
    		[PMID: 33852304]
    MCF7 IC50
    19.33 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
    		[PMID: 27311894]
    MCF7 IC50
    14.096 3
    Compound: 1; TMX
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    		[PMID: 37484572]
    MCF7 IC50
    11.8 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells expressing estrogen receptor by MTT assay
    Anticancer activity against human MCF7 cells expressing estrogen receptor by MTT assay
    		[PMID: 20951035]
    MCF7 IC50
    19.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29482944]
    MCF7 IC50
    11.35 3
    Compound: Tamoxifen
    Antiproliferative activity against ER positive human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against ER positive human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 28460819]
    MCF7 IC50
    19.54 3
    Compound: Tam
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    		[PMID: 22647217]
    MCF7 IC50
    4.1 3
    Compound: 2a
    Antiproliferative activity against ER-dependent human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against ER-dependent human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 28426931]
    MCF7 IC50
    2.1 3
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells after 5 days by WST-8 assay
    Antiproliferative activity against human MCF7 cells after 5 days by WST-8 assay
    		[PMID: 25614118]
    MCF7 IC50
    4.1 3
    Compound: Tamoxifen
    Antiproliferative activity against ER-positive human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by AlamarBlue assay
    Antiproliferative activity against ER-positive human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by AlamarBlue assay
    		[PMID: 27407030]
    HepG2 CC50
    24.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis
    Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis
    		[PMID: 30322754]
    MCF7 IC50
    20 1
    Compound: 7
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    		[PMID: 33479633]
    HepG2 CC50
    6.15 6
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 38784457]
    MCF7 IC50
    4.12 3
    Compound: 1a
    Antiproliferative activity against estrogen receptor dependent human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against estrogen receptor dependent human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 18835176]
    MCF7 IC50
    200 1
    Compound: Tamoxifen
    Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
    Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
    		[PMID: 23448346]
    HepG2 CC50
    62 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin based assay
    		[PMID: 28257200]
    MCF7 IC50
    0.14 3
    Compound: tamoxifen (TAM)
    Anti-proliferative activity against estrogen-responsive human breast cancer cell line MCF-7 in the presence of ER at a 10e-4 uM concentration of estradiol
    Anti-proliferative activity against estrogen-responsive human breast cancer cell line MCF-7 in the presence of ER at a 10e-4 uM concentration of estradiol
    		[PMID: 8784443]
    MCF7 IC50
    21.57 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 28505536]
    HepG2 EC50
    35 3
    Compound: Tamoxifen
    Cytotoxicity in human HepG2 cells assessed as induction of cell necrosis incubated for 4 hrs by LDH release assay
    Cytotoxicity in human HepG2 cells assessed as induction of cell necrosis incubated for 4 hrs by LDH release assay
    		[PMID: 27652492]
    MCF7 IC50
    22.6 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31620225]
    MCF7 IC50
    11.28 3
    Compound: 1a
    Antiproliferative activity against Human MCF-7 Breast cancer cell line in vitro.
    Antiproliferative activity against Human MCF-7 Breast cancer cell line in vitro.
    		[PMID: 11297454]
    HepG2 EC50
    35 3
    Compound: Tamoxifen
    Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 4 hrs by CellTiter-Glo assay
    Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 4 hrs by CellTiter-Glo assay
    		[PMID: 27652492]
    MCF7 IC50
    10 6
    Compound: 125
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		10.1039/C2MD20089A
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    Antiproliferative activity against human MCF7cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    		[PMID: 31673312]
    MCF7 IC50
    13.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 27155469]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by fluorescence based viable cell counting method
    Antiproliferative activity against human MCF7 cells by fluorescence based viable cell counting method
    		[PMID: 31610378]
    HepG2 GI50
    21.7 3
    Compound: Tamoxifen
    Anti-proliferative activity against human HepG2 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human HepG2 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    MCF7 IC50
    42.4 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30731397]
    HepG2 IC50
    11.7 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with galactose by CellTiter-Glo luminescent assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with galactose by CellTiter-Glo luminescent assay
    		[PMID: 37736177]
    MCF7 IC50
    27.96 3
    Compound: 1, TAM
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 23860592]
    MCF7 IC50
    54 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 33234343]
    HepG2 IC50
    11.72 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by Cell Titer Glo assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by Cell Titer Glo assay
    		[PMID: 39026652]
    MCF7 IC50
    3.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as cell viability by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MCF7 IC50
    6 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    HepG2 IC50
    12 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 30613327]
    MCF7 IC50
    3.99 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human MCF7 cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human MCF7 cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    MCF7 IC50
    30 1
    Compound: Tam
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    		[PMID: 33257172]
    HepG2 IC50
    19.6 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer 96 aqueous one solution cell proliferation assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by cell-titer 96 aqueous one solution cell proliferation assay
    		[PMID: 34015704]
    MCF7 IC50
    7.09 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30360952]
    MCF7 IC50
    31 3
    Compound: TEM
    Cytotoxicity activity against human MCF7 cells by MTS assay
    Cytotoxicity activity against human MCF7 cells by MTS assay
    		[PMID: 21680064]
    MCF7 IC50
    1.89 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 24721727]
    HepG2 IC50
    23.4 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells
    Cytotoxicity against human HepG2 cells
    		[PMID: 32386856]
    MCF7 IC50
    12.35 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23830503]
    HepG2 IC50
    23.4 3
    Compound: Tamoxifen
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with glucose by CellTiter-Glo luminescent assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with glucose by CellTiter-Glo luminescent assay
    		[PMID: 37736177]
    MCF7 IC50
    4 3
    Compound: TAM
    Cytotoxicity against human MCF7 Cells after 48 hrs by neutral red dye-based assay
    Cytotoxicity against human MCF7 Cells after 48 hrs by neutral red dye-based assay
    		[PMID: 31129455]
    HepG2 IC50
    23.4 3
    Compound: tamoxifen
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter-BlueCell viability assay
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter-BlueCell viability assay
    		[PMID: 20545334]
    MCF7 IC50
    13.45 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23902804]
    MCF7 IC50
    4.1 3
    Compound: 2a
    Antiproliferative activity against ER-dependent human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against ER-dependent human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 28426931]
    MCF7 IC50
    15.46 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29587221]
    HepG2 IC50
    6.3 3
    Compound: TAM
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    4.1 3
    Compound: 2
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 25369367]
    MCF7 IC50
    4.1 3
    Compound: Tamoxifen
    Antiproliferative activity against ER-positive human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by AlamarBlue assay
    Antiproliferative activity against ER-positive human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by AlamarBlue assay
    		[PMID: 27407030]
    MCF7 IC50
    16.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30384047]
    MCF7 IC50
    19.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29482944]
    MCF7 IC50
    4.12 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
    		[PMID: 31987694]
    MCF7 IC50
    5.5 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    4.12 3
    Compound: 1a
    Antiproliferative activity against estrogen receptor dependent human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against estrogen receptor dependent human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 18835176]
    Hepatocyte EC50
    34.4 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 24 hrs by ATP detection based assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 24 hrs by ATP detection based assay
    		[PMID: 22531045]
    MCF7 IC50
    7.65 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 19740667]
    MCF7 IC50
    4.4 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 26896706]
    MCF7 IC50
    8.12 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    Hepatocyte EC50
    67.6 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by LDH release assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by LDH release assay
    		[PMID: 22531045]
    MCF7 IC50
    4.4 3
    Compound: 2a
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by SRB assay
    		[PMID: 28426931]
    Hepatocyte EC50
    71.4 3
    Compound: Tamoxifen
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by ATP detection based assay
    Cytotoxicity against human hepatocytes assessed as reduction in cell viability after 4 hrs by ATP detection based assay
    		[PMID: 22531045]
    MCF7 IC50
    2.1 3
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells after 5 days by WST-8 assay
    Antiproliferative activity against human MCF7 cells after 5 days by WST-8 assay
    		[PMID: 25614118]
    MCF7 IC50
    4.67 3
    Compound: Tam
    Antiproliferative activity human ER-positive MCF7 cells after 2 days by MTT assay
    Antiproliferative activity human ER-positive MCF7 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MCF7 IC50
    27.96 3
    Compound: 1, TAM
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 23860592]
    Hs-578T ED50
    7 6
    Compound: TAM
    Cytotoxicity against human HS 587-T cells lacking ER
    Cytotoxicity against human HS 587-T cells lacking ER
    		[PMID: 16942038]
    MCF7 IC50
    42.4 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30731397]
    MCF7 IC50
    4.1 3
    Compound: 2
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 25369367]
    MCF7 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells expressing estrogen receptor after 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells expressing estrogen receptor after 72 hrs by SRB assay
    		[PMID: 19425534]
    MCF7 IC50
    5.09 3
    Compound: TAM
    Antiproliferative activity against MCF7 cells at 3 mg/kg/day after 48 hrs
    Antiproliferative activity against MCF7 cells at 3 mg/kg/day after 48 hrs
    		[PMID: 16979337]
    MCF7 IC50
    4.4 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 26896706]
    MCF7 IC50
    5.19 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 23806014]
    MCF7 IC50
    2.33 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
    		[PMID: 37019030]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    		[PMID: 36846377]
    MCF7 IC50
    5.3 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    MCF7 IC50
    5.3 3
    Compound: Tamoxifen
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 29220789]
    MCF7 IC50
    8.53 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    MCF7 IC50
    10 3
    Compound: 1; TMX
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth
    		[PMID: 37484572]
    MCF7 IC50
    5.4 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 34726897]
    MCF7 IC50
    5.4 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 34726897]
    MCF7 IC50
    5.5 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    Ishikawa EC50
    33 1
    Compound: 2
    Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells
    Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells
    		[PMID: 8201587]
    MCF7 IC50
    <1 2
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MCF7 IC50
    5.62 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 33894490]
    Ishikawa IC50
    0.42 3
    Compound: tamoxifen
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 4 days by ELISA
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 4 days by ELISA
    		[PMID: 9784163]
    MCF7 IC50
    11.55 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    		[PMID: 36846377]
    Ishikawa IC50
    14.58 3
    Compound: Tamoxifen
    Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34509864]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    		[PMID: 36846377]
    MCF7 IC50
    10.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    		[PMID: 36780831]
    MCF7 IC50
    19.54 3
    Compound: Tam
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    		[PMID: 22647217]
    Ishikawa IC50
    16.47 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    		[PMID: 28460819]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Cytotoxicity against human ER-positive MCF7 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human ER-positive MCF7 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26972118]
    Ishikawa IC50
    16.78 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human Ishikawa cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34022716]
    MCF7 IC50
    4.12 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
    		[PMID: 31987694]
    MCF7 IC50
    54 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 33234343]
    Ishikawa IC50
    170 1
    Compound: 1a
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 72 hrs
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 72 hrs
    		[PMID: 18835176]
    MCF7 IC50
    55.5 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MCF7 IC50
    1.31 6
    Compound: Tamoxifen
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of colony formation measured after 3 weeks by crystal violet staining based soft agar colony formation assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of colony formation measured after 3 weeks by crystal violet staining based soft agar colony formation assay
    		[PMID: 31884407]
    Ishikawa IC50
    20.65 3
    Compound: Tamoxifen
    Cytotoxicity in human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity in human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 28942113]
    MCF7 IC50
    18.71 3
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
    		[PMID: 25734623]
    MCF7 IC50
    580 1
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay
    		[PMID: 18272256]
    Ishikawa IC50
    22.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MCF7 IC50
    580 1
    Compound: 3 (Tamoxifen)
    Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
    Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
    		[PMID: 12825935]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by fluorescence based viable cell counting method
    Antiproliferative activity against human MCF7 cells by fluorescence based viable cell counting method
    		[PMID: 31610378]
    Ishikawa IC50
    26.52 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells after 48 hrs by MTT assay
    		[PMID: 29587221]
    MCF7 IC50
    1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 20451380]
    MCF7 IC50
    6 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    Ishikawa IC50
    6 3
    Compound: Tamoxifen
    Antiproliferative activity against human Ishikawa cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human Ishikawa cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    MCF7 IC50
    6.3 3
    Compound: Tamoxifen
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    MCF7 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 31546197]
    Ishikawa IC50
    7.87 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human Ishikawa cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human Ishikawa cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    MCF7 GI50
    6.5 3
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    		[PMID: 27128175]
    MCF7 IC50
    13.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT reduction assay
    Antiproliferative activity against human MCF7 cells by MTT reduction assay
    		[PMID: 33421712]
    MCF7 IC50
    10 3
    Compound: tamoxifene
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 19423356]
    MCF7 GI50
    6.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MCF7 IC50
    6.99 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by resazurin microplate assay
    Cytotoxicity against human MCF7 cells by resazurin microplate assay
    		[PMID: 27228159]
    MCF7 IC50
    12.48 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MCF7 IC50
    5.3 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    J774.A1 CC50
    11.06 3
    Compound: Tamoxifen
    Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability incubated for 24 hrs by neutral red uptake assay
    Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability incubated for 24 hrs by neutral red uptake assay
    		[PMID: 31376569]
    MCF7 IC50
    64.3 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    		[PMID: 25164760]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    Antiproliferative activity against human MCF7cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    		[PMID: 31673312]
    Jurkat IC50
    8.3 3
    Compound: Tamoxifen
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
    		[PMID: 23792352]
    MCF7 IC50
    7.09 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30360952]
    MCF7 IC50
    5.09 3
    Compound: TAM
    Antiproliferative activity against MCF7 cells at 3 mg/kg/day after 48 hrs
    Antiproliferative activity against MCF7 cells at 3 mg/kg/day after 48 hrs
    		[PMID: 16979337]
    MCF7 IC50
    7.1 3
    Compound: 2
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    K562 GI50
    5.2 3
    Compound: tamoxifen
    Antiproliferative activity against human K562 cells after 72 hrs
    Antiproliferative activity against human K562 cells after 72 hrs
    		[PMID: 25420175]
    MCF7 IC50
    7.65 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 19740667]
    KB ED50
    9 6
    Compound: TAM
    Cytotoxicity against human KB cells
    Cytotoxicity against human KB cells
    		[PMID: 16942038]
    MCF7 IC50
    4.67 3
    Compound: Tam
    Antiproliferative activity human ER-positive MCF7 cells after 2 days by MTT assay
    Antiproliferative activity human ER-positive MCF7 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MCF7 IC50
    2.3 3
    Compound: Tamoxifen
    Antiproliferative activity in MCF-7 human breast cancer cells
    Antiproliferative activity in MCF-7 human breast cancer cells
    		[PMID: 15658875]
    MCF7 IC50
    7.94 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 72 hrs by resazurin based fluorescence assay
    Cytotoxicity against human MCF7 cells after 72 hrs by resazurin based fluorescence assay
    		[PMID: 28927795]
    MCF7 IC50
    2.7 3
    Compound: Tamoxifen
    Cytostatic activity against human MCF7 cells
    Cytostatic activity against human MCF7 cells
    		[PMID: 29207335]
    L6 IC50
    4.9 6
    Compound: tamoxifen
    Cytotoxicity against rat L6 cells
    Cytotoxicity against rat L6 cells
    		[PMID: 19168363]
    MCF7 IC50
    8 6
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 24576797]
    MCF7 IC50
    8 3
    Compound: Tam Z
    Cytostaticity against MCF-7 cells in the presence of 1 uMolar E2 (estradiol)
    Cytostaticity against MCF-7 cells in the presence of 1 uMolar E2 (estradiol)
    		[PMID: 9089332]
    MCF7 GI50
    8 3
    Compound: Tamoxifen
    Anti-proliferative activity against human MCF7 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human MCF7 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    Leukemia cell GI50
    2.08 3
    Compound: TAM
    Antiproliferative activity against human leukemia cells
    Antiproliferative activity against human leukemia cells
    		[PMID: 32898794]
    MCF7 IC50
    31 3
    Compound: TEM
    Cytotoxicity activity against human MCF7 cells by MTS assay
    Cytotoxicity activity against human MCF7 cells by MTS assay
    		[PMID: 21680064]
    MCF7 IC50
    8.12 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    MCF7 IC50
    8.31 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 21115211]
    MCF7 IC50
    9.6 3
    Compound: Tamoxifen
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    MCF7 IC50
    6.3 3
    Compound: Tamoxifen
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    MCF7 IC50
    8.38 6
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells assessed a cell growth inhibition incubated for 48 hrs by SRB assay
    Anticancer activity against human MCF7 cells assessed a cell growth inhibition incubated for 48 hrs by SRB assay
    		[PMID: 32771798]
    MCF7 IC50
    8.42 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MCF7 IC50
    55.5 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Antiproliferative activity against human M-HeLa cells by fluorescence based viable cell counting method
    Antiproliferative activity against human M-HeLa cells by fluorescence based viable cell counting method
    		[PMID: 31610378]
    MCF7 IC50
    10.9 3
    Compound: Tamoxifen
    Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Antiproliferative activity against human M-HeLa cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    Antiproliferative activity against human M-HeLa cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    		[PMID: 31673312]
    MCF7 IC50
    8.5 6
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 36325400]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Cytotoxicity against human M-HeLa cells
    Cytotoxicity against human M-HeLa cells
    		[PMID: 32386856]
    MCF7 IC50
    8.53 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Cytotoxicity against human ER-positive MCF7 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human ER-positive MCF7 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26972118]
    M-HeLa IC50
    28 3
    Compound: Tmx
    Anticancer activity against human HelaM cells assessed as cell growth inhibition measured after 24 hrs by DAPI and propidium iodide staining based assay
    Anticancer activity against human HelaM cells assessed as cell growth inhibition measured after 24 hrs by DAPI and propidium iodide staining based assay
    		[PMID: 36481599]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 32386856]
    MCF7 IC50
    8.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS
    Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS
    		[PMID: 22901895]
    MCF7 IC50
    8.9 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    MCF7 IC50
    8.61 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    M21 GI50
    11 3
    Compound: Tamoxifen
    Growth inhibition of human M21 cells
    Growth inhibition of human M21 cells
    		[PMID: 23403084]
    MCF7 IC50
    8.9 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    MCF7 IC50
    9 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    MCF7 IC50
    82.5 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25164760]
    MCF7 IC50
    11.44 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    MCF7 IC50
    15.2 3
    Compound: 6
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23880359]
    MCF-10A IC50
    14.267 3
    Compound: 1; TMX
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    		[PMID: 37484572]
    MCF7 IC50
    9 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 32731188]
    MCF-10A IC50
    15 3
    Compound: 1; TMX
    Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth
    Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth
    		[PMID: 37484572]
    MCF7 IC50
    15.21 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MCF7 IC50
    9 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    MCF7 IC50
    4 3
    Compound: TAM
    Cytotoxicity against human MCF7 Cells after 48 hrs by neutral red dye-based assay
    Cytotoxicity against human MCF7 Cells after 48 hrs by neutral red dye-based assay
    		[PMID: 31129455]
    MCF-10A IC50
    26.8 3
    Compound: TMX
    Cytotoxicity against human MCF-10A assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    Cytotoxicity against human MCF-10A assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    		[PMID: 38020071]
    MCF7 IC50
    9.6 3
    Compound: Tamoxifen
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    MDA-MB-231 IC50
    < 1000 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MCF7 IC50
    0.027 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 22472045]
    MCF-10A IC50
    8.263 3
    Compound: 1; TMX
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    Anticancer activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    		[PMID: 37484572]
    MCF-10A IC50
    > 1000 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MCF7 IC50
    8.31 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 21115211]
    MDA-MB-231 IC50
    > 20 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    MCF-10A IC50
    > 1000 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MCF7 IC50
    1.82 3
    Compound: TAMOX, TAM
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 23123017]
    MDA-MB-231 IC50
    > 50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34022716]
    MCF7 IC50
    8 6
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 24576797]
    MCF-10A IC50
    > 50 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF-10A cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF-10A cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MDA-MB-231 IC50
    > 50 3
    Compound: Tamoxifen
    Cytotoxicity against human ER-negative MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human ER-negative MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26972118]
    MCF7 IC50
    0.794 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 5 days
    Cytotoxicity against human MCF7 cells after 5 days
    		[PMID: 23864928]
    MDA-MB-231 IC50
    0.66 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 20451380]
    MCF7 IC50
    7.94 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 72 hrs by resazurin based fluorescence assay
    Cytotoxicity against human MCF7 cells after 72 hrs by resazurin based fluorescence assay
    		[PMID: 28927795]
    MDA-MB-231 IC50
    10 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    MCF7 IC50
    8.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS
    Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS
    		[PMID: 22901895]
    MDA-MB-231 IC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    MDA-MB-231 IC50
    10.11 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MCF7 IC50
    7.1 87
    Compound: 2
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    MDA-MB-231 IC50
    11.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 31546197]
    MCF7 IC50
    5.62 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 33894490]
    MDA-MB-231 IC50
    11.4 3
    Compound: TAM
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    3.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as cell viability by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MCF7 IC50
    82.5 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25164760]
    MDA-MB-231 IC50
    12.4 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    		[PMID: 19836230]
    MCF7 IC50
    21.57 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 28505536]
    MDA-MB-231 IC50
    12.41 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    MDA-MB-231 IC50
    13.9 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    MCF7 IC50
    4.4 3
    Compound: 2a
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by SRB assay
    		[PMID: 28426931]
    MCF7 IC50
    64.3 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    		[PMID: 25164760]
    MDA-MB-231 IC50
    14 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    MCF7 IC50
    19.2 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin based fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin based fluorescence assay
    		[PMID: 33852304]
    MDA-MB-231 IC50
    14.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT reduction assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT reduction assay
    		[PMID: 33421712]
    MDA-MB-231 IC50
    14.94 3
    Compound: 1
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    MCF7 IC50
    19.33 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
    		[PMID: 27311894]
    MDA-MB-231 IC50
    15.01 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 33894490]
    MCF7 IC50
    8.42 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MDA-MB-231 GI50
    15.1 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MCF7 IC50
    22.6 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31620225]
    MDA-MB-231 IC50
    17 3
    Compound: Tamoxifen
    Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    MCF7 IC50
    6.99 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by resazurin microplate assay
    Cytotoxicity against human MCF7 cells by resazurin microplate assay
    		[PMID: 27228159]
    MDA-MB-231 IC50
    18.48 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MCF7 IC50
    5.19 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 23806014]
    MCF7 IC50
    8.5 6
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 36325400]
    MDA-MB-231 IC50
    18.9 3
    Compound: Tamoxifen
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MDA-MB-231 IC50
    19 3
    Compound: Tamoxifen
    Inhibitory concentration against MDA-MB-231 (ER-) cell line using SRB assay
    Inhibitory concentration against MDA-MB-231 (ER-) cell line using SRB assay
    		[PMID: 12565971]
    MCF7 IC50
    11.4 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by WST-1 assay
    Cytotoxicity against human MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    MCF7 IC50
    12.5 3
    Compound: Tam
    Cytotoxicity against human MCF7 cells expressing ER after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing ER after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MDA-MB-231 IC50
    20 3
    Compound: tamoxifene
    Antiproliferative activity against human estrogen receptor deficient MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human estrogen receptor deficient MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 19423356]
    MCF7 IC50
    15.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    MDA-MB-231 IC50
    24 3
    Compound: tamoxifen
    Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay
    Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay
    		[PMID: 19446930]
    MCF7 IC50
    10.74 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MDA-MB-231 IC50
    25.1 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MDA-MB-231 IC50
    27 3
    Compound: Tam
    Cytotoxicity against human ER negative MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human ER negative MDA-MB-231 cells after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 IC50
    8.61 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    MCF7 IC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    MDA-MB-231 IC50
    35.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MDA-MB-231 IC50
    38.97 3
    Compound: Tam
    Antiproliferative activity human ER-negative MDA-MB-231 cells after 2 days by MTT assay
    Antiproliferative activity human ER-negative MDA-MB-231 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MCF7 IC50
    14.35 3
    Compound: Tamoxifen
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 28942113]
    MCF7 IC50
    5.3 3
    Compound: Tamoxifen
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 29220789]
    MDA-MB-231 IC50
    47.1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 30360952]
    MCF7 IC50
    14 3
    Compound: 1
    In vitro cytotoxicity against hormone-responsive MCF-7 cell line.
    In vitro cytotoxicity against hormone-responsive MCF-7 cell line.
    		[PMID: 7830266]
    MDA-MB-231 IC50
    5.9 3
    Compound: Tamoxifen
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    MCF7 IC50
    17 3
    Compound: Tamoxifen
    In vitro inhibition of estrogen receptor positive MCF-7 human mammary carcinoma cell proliferation
    In vitro inhibition of estrogen receptor positive MCF-7 human mammary carcinoma cell proliferation
    		10.1016/0960-894X(95)00381-3
    MDA-MB-231 IC50
    64.85 3
    Compound: 1, TAM
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 23860592]
    MCF7 IC50
    5.8 3
    Compound: Tamoxifen
    Induction of apoptosis in human MCF7 cells in presence of EGCG at 50 uM
    Induction of apoptosis in human MCF7 cells in presence of EGCG at 50 uM
    		[PMID: 36780831]
    MDA-MB-231 IC50
    69.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
    		[PMID: 33139111]
    MCF7 IC50
    19 3
    Compound: tamoxifen (TAM)
    Inhibition of 10e-4 uM estradiol induced estrogen receptor positive MCF-7 human breast cancer cell proliferation
    Inhibition of 10e-4 uM estradiol induced estrogen receptor positive MCF-7 human breast cancer cell proliferation
    		[PMID: 8784443]
    MDA-MB-231 IC50
    7 3
    Compound: Tamoxifen
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    MCF7 IC50
    3.99 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human MCF7 cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human MCF7 cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    MDA-MB-231 IC50
    7.85 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human MDA-MB-231 cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human MDA-MB-231 cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    MCF7 IC50
    0.15 3
    Compound: Tamoxifen, ICI-46474
    Inhibition of estrogen receptor positive MCF-7 human breast cancer cell proliferation
    Inhibition of estrogen receptor positive MCF-7 human breast cancer cell proliferation
    		[PMID: 9357519]
    MDA-MB-231 IC50
    75 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 33234343]
    MDA-MB-231 IC50
    75 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    		[PMID: 25164760]
    MCF7 IC50
    11 3
    Compound: Tamoxifen
    Inhibitory concentration against MCF-7 (ER+) cell line using SRB assay
    Inhibitory concentration against MCF-7 (ER+) cell line using SRB assay
    		[PMID: 12565971]
    MCF7 IC50
    70 1
    Compound: Tamoxifen
    Inhibition of estrogen receptor positive MCF-7 breast cancer cell proliferation
    Inhibition of estrogen receptor positive MCF-7 breast cancer cell proliferation
    		[PMID: 14971899]
    MDA-MB-231 IC50
    84.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25164760]
    MDA-MB-231 ED50
    8.5 6
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells lacking ER
    Cytotoxicity against human MDA-MB-231 cells lacking ER
    		[PMID: 16942038]
    MDA-MB-231 IC50
    9.86 3
    Compound: TAM
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 19740667]
    MDA-MB-231 IC50
    9.96 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    MDA-MB-231 GI50
    0.24 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells
    Cytotoxicity against human MDA-MB-231 cells
    		[PMID: 31200236]
    MDA-MB-231 GI50
    15.1 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MDA-MB-435 GI50
    3.16 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MDA-MB-231 GI50
    18.8 3
    Compound: Tamoxifen
    Growth inhibition of estrogen-independent human MDA-MB-231 cells
    Growth inhibition of estrogen-independent human MDA-MB-231 cells
    		[PMID: 23403084]
    MDA-MB-435S IC50
    5.5 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-435S cells assessed as cell viability by MTT assay
    Cytotoxicity against human MDA-MB-435S cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MDA-MB-468 IC50
    14.99 3
    Compound: Tam
    Cytotoxicity against human ER negative MDA-MB-468 cells after 48 hrs by MTT assay
    Cytotoxicity against human ER negative MDA-MB-468 cells after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MDA-MB-231 GI50
    0.12 3
    Compound: Tamoxifen
    Growth inhibition of human MDA-MB-231 cells
    Growth inhibition of human MDA-MB-231 cells
    		[PMID: 31605865]
    MDA-MB-231 GI50
    0.24 3
    Compound: Tamoxifen
    Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by SRB assay
    Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by SRB assay
    		[PMID: 36577217]
    MDA-MB-468 GI50
    2.5 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MDA-MB-231 IC50
    24 3
    Compound: tamoxifen
    Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay
    Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay
    		[PMID: 19446930]
    MEL-JUSO EC50
    14.6 3
    Compound: TAM
    Antiproliferative activity against human MelJuSo cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    Antiproliferative activity against human MelJuSo cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    		[PMID: 31099568]
    MDA-MB-231 IC50
    30.848 3
    Compound: 1; TMX
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    		[PMID: 37484572]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Antiproliferative activity against human M-HeLa cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    Antiproliferative activity against human M-HeLa cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    		[PMID: 31673312]
    MDA-MB-231 IC50
    25.575 3
    Compound: 1; TMX
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    		[PMID: 37484572]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Antiproliferative activity against human M-HeLa cells by fluorescence based viable cell counting method
    Antiproliferative activity against human M-HeLa cells by fluorescence based viable cell counting method
    		[PMID: 31610378]
    MDA-MB-231 IC50
    18.9 3
    Compound: Tamoxifen
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MIA PaCa-2 IC50
    33.12 3
    Compound: Tam
    Antiproliferative activity human MIAPaCa2 cells after 2 days by MTT assay
    Antiproliferative activity human MIAPaCa2 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MDA-MB-231 IC50
    20 3
    Compound: tamoxifene
    Antiproliferative activity against human estrogen receptor deficient MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human estrogen receptor deficient MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 19423356]
    MOLT-4 GI50
    2.5 3
    Compound: TAM
    Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MDA-MB-231 IC50
    17.9 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells
    Antiproliferative activity against human MDA-MB-231 cells
    		[PMID: 27155469]
    MRC5 CC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells measured after 7 days by MTT assay
    Cytotoxicity against human MRC5 cells measured after 7 days by MTT assay
    		[PMID: 33667089]
    MDA-MB-231 IC50
    14 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    MRC5 IC50
    10.9 3
    Compound: TAM
    Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
    Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
    		[PMID: 26922226]
    MCF7 EC50
    0.11 1
    Compound: TAM Z
    Effective dose for [3H]- estradiol against proliferation of MCF-7 cells
    Effective dose for [3H]- estradiol against proliferation of MCF-7 cells
    		[PMID: 2769681]
    MRC5 IC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
    Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
    		[PMID: 30879839]
    MDA-MB-231 IC50
    47.1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 30360952]
    MDA-MB-231 IC50
    75 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 33234343]
    MCF7 EC50
    10 1
    Compound: 3 (Tamoxifen)
    Effective concentration against MCF-7 breast tumor cells using MCF-7 assay.
    Effective concentration against MCF-7 breast tumor cells using MCF-7 assay.
    		[PMID: 12825935]
    MRC5 CC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based fluorimetric assay
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based fluorimetric assay
    		[PMID: 30857749]
    MCF7 EC50
    > 200 1
    Compound: 2
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by Cell-titer Glo assay
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by Cell-titer Glo assay
    		[PMID: 34251202]
    MDA-MB-231 IC50
    11.4 3
    Compound: TAM
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MRC5 IC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells after 24 hrs by resazurin dye based assay
    Cytotoxicity against human MRC5 cells after 24 hrs by resazurin dye based assay
    		[PMID: 30692024]
    MCF7 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells expressing ER
    Cytotoxicity against human MCF7 cells expressing ER
    		[PMID: 16942038]
    MRC5 IC50
    17.2 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    		[PMID: 36242986]
    MDA-MB-231 IC50
    9.86 3
    Compound: TAM
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 19740667]
    MDA-MB-231 IC50
    9.96 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    MCF7 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells expressing estrogen receptor after 72 hrs by SRB assay
    Cytotoxicity against human MCF7 cells expressing estrogen receptor after 72 hrs by SRB assay
    		[PMID: 19425534]
    MSTO-211H GI50
    23.3 3
    Compound: 1
    Antiproliferative activity against human MSTO-211H cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human MSTO-211H cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    MDA-MB-231 IC50
    64.85 3
    Compound: 1, TAM
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 23860592]
    NCI/ADR-RES IC50
    11.13 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7/ADR cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7/ADR cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    NCI-H460 GI50
    4.48 3
    Compound: Tamoxifen
    Anticancer activity against human NCI-H460 cells after 24 hrs by SRB assay
    Anticancer activity against human NCI-H460 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    MDA-MB-231 IC50
    69.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
    		[PMID: 33139111]
    MDA-MB-231 IC50
    14.94 3
    Compound: 1
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    NIH3T3 IC50
    > 100 3
    Compound: Tam
    Antiproliferative activity mouse NIH/3T3 cells after 2 days by MTT assay
    Antiproliferative activity mouse NIH/3T3 cells after 2 days by MTT assay
    		[PMID: 25222876]
    NIH3T3 IC50
    11.4 3
    Compound: TAM
    Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MDA-MB-231 IC50
    25 3
    Compound: 1; TMX
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth
    		[PMID: 37484572]
    NIH3T3 IC50
    7.26 3
    Compound: 2
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    MDA-MB-231 IC50
    <1 2
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MDA-MB-231 IC50
    >20 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    OVCAR-5 GI50
    32 3
    Compound: 1
    Cytotoxicity against human OVCAR5 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against human OVCAR5 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    		[PMID: 27128175]
    MDA-MB-231 IC50
    >50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34022716]
    PC-3 IC50
    > 1000 1
    Compound: 7
    Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    		[PMID: 33479633]
    MDA-MB-231 IC50
    0.66 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 20451380]
    MCF7 GI50
    1.58 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    PC-3 IC50
    10 3
    Compound: TAM
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 GI50
    11.2 3
    Compound: Tamoxifen
    Growth inhibition of estrogen-dependent human MCF7 cells
    Growth inhibition of estrogen-dependent human MCF7 cells
    		[PMID: 23403084]
    MDA-MB-231 IC50
    11.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 31546197]
    PC-3 IC50
    15.8 3
    Compound: TAM
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MCF7 GI50
    12 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    PC-3 IC50
    7 3
    Compound: Tamoxifen
    Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    MDA-MB-231 IC50
    14.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT reduction assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT reduction assay
    		[PMID: 33421712]
    MDA-MB-231 IC50
    13.9 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    MCF7 GI50
    6.5 3
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by trypan blue assay
    		[PMID: 27128175]
    RAW264.7 CC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by neutral red dye based assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by neutral red dye based assay
    		[PMID: 31703818]
    MCF7 GI50
    6.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    RAW264.7 IC50
    18.5 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    		[PMID: 36242986]
    MDA-MB-231 IC50
    38.97 3
    Compound: Tam
    Antiproliferative activity human ER-negative MDA-MB-231 cells after 2 days by MTT assay
    Antiproliferative activity human ER-negative MDA-MB-231 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MCF7 GI50
    8 3
    Compound: Tamoxifen
    Anti-proliferative activity against human MCF7 cells incubated for 48 hrs by SRB assay
    Anti-proliferative activity against human MCF7 cells incubated for 48 hrs by SRB assay
    		[PMID: 26163220]
    MDA-MB-231 IC50
    18.08 3
    Compound: Tamoxifen
    Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition of protein translation
    Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition of protein translation
    		[PMID: 30530174]
    SH-SY5Y IC50
    20 3
    Compound: Tamoxifen
    Inhibition of PKC in human SH-SY5Y cells assessed as inhibition of PMA-stimulated MARCKS phosphorylation preincubated for 1 hr followed by PMA-stimulation for 15 mins by Western blot analysis
    Inhibition of PKC in human SH-SY5Y cells assessed as inhibition of PMA-stimulated MARCKS phosphorylation preincubated for 1 hr followed by PMA-stimulation for 15 mins by Western blot analysis
    		[PMID: 27647375]
    MCF7 GI50
    < 10 6
    Compound: Tmx
    Growth inhibition of human MCF7 cells assessed as cell growth inhibition by SRB assay
    Growth inhibition of human MCF7 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 36481599]
    MDA-MB-231 IC50
    17 3
    Compound: Tamoxifen
    Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    SK-BR-3 IC50
    < 1000 3
    Compound: Tamoxifen
    Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    SK-BR-3 GI50
    12.5 3
    Compound: Tamoxifen
    Cytotoxicity against human SKBR3 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human SKBR3 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MDA-MB-231 IC50
    7 3
    Compound: Tamoxifen
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    MDA-MB-231 IC50
    5.9 3
    Compound: Tamoxifen
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    SK-BR-3 IC50
    28.32 3
    Compound: Tamoxifen
    Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
    Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MCF7 IC50
    0.027 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 22472045]
    MDA-MB-231 IC50
    25.1 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MCF7 IC50
    0.14 3
    Compound: tamoxifen (TAM)
    Anti-proliferative activity against estrogen-responsive human breast cancer cell line MCF-7 in the presence of ER at a 10e-4 uM concentration of estradiol
    Anti-proliferative activity against estrogen-responsive human breast cancer cell line MCF-7 in the presence of ER at a 10e-4 uM concentration of estradiol
    		[PMID: 8784443]
    SK-BR-3 ED50
    5 6
    Compound: TAM
    Cytotoxicity against estrogen receptor deficient human SKBR3 cells overexpressing human epidermal growth factor receptor 2 after 72 hrs by SRB assay
    Cytotoxicity against estrogen receptor deficient human SKBR3 cells overexpressing human epidermal growth factor receptor 2 after 72 hrs by SRB assay
    		[PMID: 19425534]
    MDA-MB-231 IC50
    27 3
    Compound: Tam
    Cytotoxicity against human ER negative MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human ER negative MDA-MB-231 cells after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 IC50
    0.15 3
    Compound: Tamoxifen, ICI-46474
    Inhibition of estrogen receptor positive MCF-7 human breast cancer cell proliferation
    Inhibition of estrogen receptor positive MCF-7 human breast cancer cell proliferation
    		[PMID: 9357519]
    SK-MEL-28 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human SK-MEL-28 cells by alamar blue assay
    Cytotoxicity against human SK-MEL-28 cells by alamar blue assay
    		[PMID: 11720540]
    MDA-MB-231 IC50
    >50 3
    Compound: Tamoxifen
    Cytotoxicity against human ER-negative MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human ER-negative MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26972118]
    SK-OV-3 GI50
    10 3
    Compound: TAM
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    0.794 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 5 days
    Cytotoxicity against human MCF7 cells after 5 days
    		[PMID: 23864928]
    MDA-MB-231 IC50
    25.9 3
    Compound: TMX
    Cytotoxicity against human MDA-MB-231 assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    Cytotoxicity against human MDA-MB-231 assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    		[PMID: 38020071]
    SK-OV-3 GI50
    6.4 3
    Compound: Tamoxifen
    Anticancer activity against human SKOV3 cells after 24 hrs by SRB assay
    Anticancer activity against human SKOV3 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    MCF7 IC50
    1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 20451380]
    MDA-MB-231 IC50
    10 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    SNB-75 GI50
    5.01 3
    Compound: TAM
    Cytotoxicity against human SNB75 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human SNB75 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    1.31 6
    Compound: Tamoxifen
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of colony formation measured after 3 weeks by crystal violet staining based soft agar colony formation assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of colony formation measured after 3 weeks by crystal violet staining based soft agar colony formation assay
    		[PMID: 31884407]
    MCF7 IC50
    1.56 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells incubated for 5 days by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 5 days by MTT assay
    		[PMID: 38870830]
    MDA-MB-231 IC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    T47D IC50
    0.1 3
    Compound: Tamoxifen
    Antiestrogenic activity in human T47D cells expressing estrogen receptor assessed as estrogen-dependent transcription by luciferase reporter gene assay
    Antiestrogenic activity in human T47D cells expressing estrogen receptor assessed as estrogen-dependent transcription by luciferase reporter gene assay
    		[PMID: 19131248]
    MDA-MB-231 IC50
    12.41 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    T47D IC50
    1 3
    Compound: Tamoxifen
    Growth inhibition of human estrogen-dependent T47D cells after 72 hrs
    Growth inhibition of human estrogen-dependent T47D cells after 72 hrs
    		[PMID: 19131248]
    MCF7 IC50
    1.82 3
    Compound: TAMOX, TAM
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 23123017]
    MDA-MB-231 IC50
    35.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MCF7 IC50
    1.89 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 24721727]
    T47D IC50
    1.13 3
    Compound: Tamoxifen
    Cytotoxicity against human T47D cells after 5 days
    Cytotoxicity against human T47D cells after 5 days
    		[PMID: 23864928]
    MDA-MB-231 IC50
    15.01 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 33894490]
    T47D GI50
    1.99 3
    Compound: TAM
    Cytotoxicity against human T47D cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    10 3
    Compound: 1; TMX
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth
    		[PMID: 37484572]
    MDA-MB-231 IC50
    84.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25164760]
    T47D GI50
    10.6 3
    Compound: Tamoxifen
    Cytotoxicity against human T47D cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MCF7 IC50
    10 3
    Compound: tamoxifene
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 19423356]
    T47D IC50
    12.1 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) T47D cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) T47D cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MDA-MB-231 IC50
    75 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    		[PMID: 25164760]
    MCF7 IC50
    10.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
    		[PMID: 36780831]
    MDA-MB-231 IC50
    10.11 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    T47D IC50
    13 3
    Compound: TAM
    Antiproliferative activity against human T47D cells after 48 hrs by MTT assay
    Antiproliferative activity against human T47D cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    10.74 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MDA-MB-231 IC50
    12.4 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    		[PMID: 19836230]
    T47D IC50
    14.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human T47D cells by MTT reduction assay
    Antiproliferative activity against human T47D cells by MTT reduction assay
    		[PMID: 33421712]
    MCF7 IC50
    10.87 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT assay
    Antiproliferative activity against human MCF7 cells by MTT assay
    		[PMID: 31546197]
    MDA-MB-231 IC50
    18.48 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    T47D IC50
    29.9 3
    Compound: Tam
    Cytotoxicity against human T47D cells expressing ER after 48 hrs by MTT assay
    Cytotoxicity against human T47D cells expressing ER after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 IC50
    10.9 3
    Compound: Tamoxifen
    Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human adriamycin- resistant MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    MDA-MB-231 IC50
    28 3
    Compound: Tamoxifen
    In vitro inhibition of estrogen receptor negative MDA-MD-231 human mammary carcinoma cell proliferation
    In vitro inhibition of estrogen receptor negative MDA-MD-231 human mammary carcinoma cell proliferation
    		10.1016/0960-894X(95)00381-3
    MCF7 IC50
    10 6
    Compound: 125
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		10.1039/C2MD20089A
    T47D IC50
    34.42 3
    Compound: Tamoxifen
    Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
    Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
    		[PMID: 30731397]
    MCF7 IC50
    11 3
    Compound: Tamoxifen
    Inhibitory concentration against MCF-7 (ER+) cell line using SRB assay
    Inhibitory concentration against MCF-7 (ER+) cell line using SRB assay
    		[PMID: 12565971]
    MDA-MB-231 IC50
    7.85 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human MDA-MB-231 cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human MDA-MB-231 cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    THP-1 IC50
    11.91 3
    Compound: Tamoxifen
    Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    MDA-MB-231 IC50
    19 3
    Compound: Tamoxifen
    Inhibitory concentration against MDA-MB-231 (ER-) cell line using SRB assay
    Inhibitory concentration against MDA-MB-231 (ER-) cell line using SRB assay
    		[PMID: 12565971]
    MCF7 IC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    UO-31 GI50
    6.3 3
    Compound: TAM
    Cytotoxicity against human UO31 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human UO31 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    Vero IC50
    15.9 3
    Compound: Tamoxifen
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    MCF7 IC50
    11.28 3
    Compound: 1a
    Antiproliferative activity against Human MCF-7 Breast cancer cell line in vitro.
    Antiproliferative activity against Human MCF-7 Breast cancer cell line in vitro.
    		[PMID: 11297454]
    MDA-MB-435 GI50
    3.16 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    Vero IC50
    36.2 3
    Compound: Tamoxifen
    Cytotoxicity against african green monkey Vero cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against african green monkey Vero cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MCF7 IC50
    11.35 3
    Compound: Tamoxifen
    Antiproliferative activity against ER positive human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against ER positive human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 28460819]
    MDA-MB-435 IC50
    0.1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-435 cells
    Antiproliferative activity against human MDA-MB-435 cells
    		[PMID: 33421712]
    MDA-MB-231 IC50
    80 1
    Compound: Tamoxifen
    Inhibition of estrogen receptor negative MDA-MB-231 breast cancer cell proliferation
    Inhibition of estrogen receptor negative MDA-MB-231 breast cancer cell proliferation
    		[PMID: 14971899]
    MCF7 IC50
    11.4 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by WST-1 assay
    Cytotoxicity against human MCF7 cells by WST-1 assay
    		[PMID: 19836230]
    Vero IC50
    5.7 3
    Compound: Tamoxifen
    Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
    Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MDA-MB-435S IC50
    5.5 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-435S cells assessed as cell viability by MTT assay
    Cytotoxicity against human MDA-MB-435S cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MCF7 IC50
    11.44 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    MCF7 IC50
    11.55 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    MCF7 IC50
    11.8 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells expressing estrogen receptor by MTT assay
    Anticancer activity against human MCF7 cells expressing estrogen receptor by MTT assay
    		[PMID: 20951035]
    MDA-MB-468 GI50
    2.5 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    12 3
    Compound: tamoxifen
    Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay
    Anticancer activity against estrogen-positive human MCF7 cells after 18 hrs by MTT assay
    		[PMID: 19446930]
    MDA-MB-468 IC50
    14.99 3
    Compound: Tam
    Cytotoxicity against human ER negative MDA-MB-468 cells after 48 hrs by MTT assay
    Cytotoxicity against human ER negative MDA-MB-468 cells after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 IC50
    12.35 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23830503]
    MEL-JUSO EC50
    14.6 3
    Compound: TAM
    Antiproliferative activity against human MelJuSo cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    Antiproliferative activity against human MelJuSo cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    		[PMID: 31099568]
    MCF7 IC50
    12.48 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    M-HeLa IC50
    28 3
    Compound: Tmx
    Anticancer activity against human HelaM cells assessed as cell growth inhibition measured after 24 hrs by DAPI and propidium iodide staining based assay
    Anticancer activity against human HelaM cells assessed as cell growth inhibition measured after 24 hrs by DAPI and propidium iodide staining based assay
    		[PMID: 36481599]
    MCF7 IC50
    12.5 3
    Compound: Tam
    Cytotoxicity against human MCF7 cells expressing ER after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing ER after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 IC50
    12.6 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 38911170]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Antiproliferative activity against human M-HeLa cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    Antiproliferative activity against human M-HeLa cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    		[PMID: 31673312]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Antiproliferative activity against human M-HeLa cells by fluorescence based viable cell counting method
    Antiproliferative activity against human M-HeLa cells by fluorescence based viable cell counting method
    		[PMID: 31610378]
    MCF7 IC50
    13.45 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23902804]
    MCF7 IC50
    13.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 27155469]
    M-HeLa IC50
    28 3
    Compound: Tamoxifen
    Cytotoxicity against human M-HeLa cells
    Cytotoxicity against human M-HeLa cells
    		[PMID: 32386856]
    MCF7 IC50
    13.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by MTT reduction assay
    Antiproliferative activity against human MCF7 cells by MTT reduction assay
    		[PMID: 33421712]
    MIA PaCa-2 IC50
    33.12 3
    Compound: Tam
    Antiproliferative activity human MIAPaCa2 cells after 2 days by MTT assay
    Antiproliferative activity human MIAPaCa2 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MOLT-4 GI50
    2.5 3
    Compound: TAM
    Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    14 3
    Compound: 1
    In vitro cytotoxicity against hormone-responsive MCF-7 cell line.
    In vitro cytotoxicity against hormone-responsive MCF-7 cell line.
    		[PMID: 7830266]
    MRC5 CC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based fluorimetric assay
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based fluorimetric assay
    		[PMID: 30857749]
    MCF7 IC50
    14.096 3
    Compound: 1; TMX
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    		[PMID: 37484572]
    MRC5 CC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells measured after 7 days by MTT assay
    Cytotoxicity against human MRC5 cells measured after 7 days by MTT assay
    		[PMID: 33667089]
    MCF7 IC50
    14.35 3
    Compound: Tamoxifen
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
    		[PMID: 28942113]
    MCF7 IC50
    15.2 3
    Compound: 6
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23880359]
    MRC5 IC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells after 24 hrs by resazurin dye based assay
    Cytotoxicity against human MRC5 cells after 24 hrs by resazurin dye based assay
    		[PMID: 30692024]
    MRC5 IC50
    10.9 3
    Compound: TAM
    Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
    Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
    		[PMID: 26922226]
    MCF7 IC50
    15.21 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MRC5 IC50
    17.2 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    		[PMID: 36242986]
    MCF7 IC50
    15.46 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29587221]
    MRC5 IC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
    Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
    		[PMID: 30879839]
    MCF7 IC50
    15.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells expressing ERalpha and ERbeta assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    MCF7 IC50
    16.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30384047]
    MSTO-211H GI50
    23.3 3
    Compound: 1
    Antiproliferative activity against human MSTO-211H cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human MSTO-211H cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    MCF7 IC50
    17 3
    Compound: Tamoxifen
    In vitro inhibition of estrogen receptor positive MCF-7 human mammary carcinoma cell proliferation
    In vitro inhibition of estrogen receptor positive MCF-7 human mammary carcinoma cell proliferation
    		10.1016/0960-894X(95)00381-3
    Ishikawa IC50
    170 1
    Compound: 1a
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 72 hrs
    Antiestrogenic activity in human Ishikawa cells assessed as inhibition of estrogen-induced alkaline phosphatase activity after 72 hrs
    		[PMID: 18835176]
    MCF7 IC50
    18.18 3
    Compound: Tamoxifen
    Anticancer activity against human ER-positive MCF7 cells measured after 48 hrs by SRB assay
    Anticancer activity against human ER-positive MCF7 cells measured after 48 hrs by SRB assay
    		[PMID: 27671497]
    MCF7 IC50
    18.71 3
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
    		[PMID: 25734623]
    MCF7 IC50
    200 1
    Compound: Tamoxifen
    Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
    Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
    		[PMID: 23448346]
    MCF7 IC50
    19 3
    Compound: tamoxifen (TAM)
    Inhibition of 10e-4 uM estradiol induced estrogen receptor positive MCF-7 human breast cancer cell proliferation
    Inhibition of 10e-4 uM estradiol induced estrogen receptor positive MCF-7 human breast cancer cell proliferation
    		[PMID: 8784443]
    NCI/ADR-RES IC50
    11.13 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7/ADR cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7/ADR cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    NCI/ADR-RES IC50
    2 3
    Compound: Tamoxifen
    Inhibition of MCF-7/Adr breast cancer cell proliferation
    Inhibition of MCF-7/Adr breast cancer cell proliferation
    		[PMID: 14971899]
    MCF7 IC50
    19.2 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin based fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin based fluorescence assay
    		[PMID: 33852304]
    MCF7 IC50
    219 1
    Compound: TAM Z
    In vitro inhibition of MCF-7 cell proliferation compared to 0.1 nM [3H]-estradiol.
    In vitro inhibition of MCF-7 cell proliferation compared to 0.1 nM [3H]-estradiol.
    		[PMID: 2769681]
    MCF7 IC50
    19.33 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
    		[PMID: 27311894]
    MCF7 IC50
    19.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29482944]
    NCI-H460 GI50
    4.48 3
    Compound: Tamoxifen
    Anticancer activity against human NCI-H460 cells after 24 hrs by SRB assay
    Anticancer activity against human NCI-H460 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    MCF7 IC50
    19.54 3
    Compound: Tam
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 24 hrs by MTT assay
    		[PMID: 22647217]
    NIH3T3 IC50
    11.4 3
    Compound: TAM
    Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    2.1 3
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells after 5 days by WST-8 assay
    Antiproliferative activity against human MCF7 cells after 5 days by WST-8 assay
    		[PMID: 25614118]
    NIH3T3 IC50
    >100 3
    Compound: Tam
    Antiproliferative activity mouse NIH/3T3 cells after 2 days by MTT assay
    Antiproliferative activity mouse NIH/3T3 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MCF7 IC50
    2.3 3
    Compound: Tamoxifen
    Antiproliferative activity in MCF-7 human breast cancer cells
    Antiproliferative activity in MCF-7 human breast cancer cells
    		[PMID: 15658875]
    NIH3T3 IC50
    7.26 87
    Compound: 2
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    MCF7 IC50
    2.33 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
    		[PMID: 37019030]
    MCF7 IC50
    2.7 3
    Compound: Tamoxifen
    Cytostatic activity against human MCF7 cells
    Cytostatic activity against human MCF7 cells
    		[PMID: 29207335]
    MCF7 IC50
    20 1
    Compound: 7
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    		[PMID: 33479633]
    OVCAR-5 GI50
    32 3
    Compound: 1
    Cytotoxicity against human OVCAR5 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against human OVCAR5 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    		[PMID: 27128175]
    MCF7 IC50
    20.24 3
    Compound: Tmx
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    		[PMID: 36481599]
    MCF7 IC50
    200 1
    Compound: Tamoxifen
    Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
    Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
    		[PMID: 23448346]
    MCF7 IC50
    21.57 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
    		[PMID: 28505536]
    MCF7 IC50
    481 1
    Compound: 1 (tamoxifen)
    Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells
    Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells
    		[PMID: 9154963]
    MCF7 IC50
    219 1
    Compound: TAM Z
    In vitro inhibition of MCF-7 cell proliferation compared to 0.1 nM [3H]-estradiol.
    In vitro inhibition of MCF-7 cell proliferation compared to 0.1 nM [3H]-estradiol.
    		[PMID: 2769681]
    PC-3 IC50
    >40 3
    Compound: Tamoxifen
    Antiproliferative activity against human PC3 cells
    Antiproliferative activity against human PC3 cells
    		[PMID: 27155469]
    MCF7 IC50
    22.47 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 37875056]
    PC-3 IC50
    7 3
    Compound: Tamoxifen
    Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    MCF7 IC50
    22.6 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31620225]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells by fluorescence based viable cell counting method
    Antiproliferative activity against human MCF7 cells by fluorescence based viable cell counting method
    		[PMID: 31610378]
    PC-3 IC50
    10 3
    Compound: TAM
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    Antiproliferative activity against human MCF7cells assessed as reduction in cell viability after 24 hrs by DAPI/propidium iodide staining based assay
    		[PMID: 31673312]
    PC-3 IC50
    >1 3
    Compound: 7
    Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    		[PMID: 33479633]
    MCF7 IC50
    25 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 32386856]
    MCF7 IC50
    25.787 3
    Compound: 1; TMX
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    		[PMID: 37484572]
    PC-3 IC50
    15.8 3
    Compound: TAM
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MCF7 IC50
    27.96 3
    Compound: 1, TAM
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 23860592]
    MCF7 IC50
    580 1
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay
    		[PMID: 18272256]
    MCF7 IC50
    580 1
    Compound: 3 (Tamoxifen)
    Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
    Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
    		[PMID: 12825935]
    MCF7 IC50
    3.53 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells
    Anticancer activity against human MCF7 cells
    		[PMID: 31926469]
    HeLa IC50
    622 1
    Compound: 6
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor alpha; ERE assay
    Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor alpha; ERE assay
    		[PMID: 15658851]
    MCF7 IC50
    3.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as cell viability by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    RAW264.7 CC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by neutral red dye based assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by neutral red dye based assay
    		[PMID: 31703818]
    MCF7 IC50
    3.99 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human MCF7 cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human MCF7 cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    RAW264.7 CC50
    5.03 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction of cell viability incubated for 72 hrs by Cell Titer-Glo assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction of cell viability incubated for 72 hrs by Cell Titer-Glo assay
    		[PMID: 37871508]
    MCF7 IC50
    30 1
    Compound: Tam
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    		[PMID: 33257172]
    MCF7 IC50
    31 3
    Compound: TEM
    Cytotoxicity activity against human MCF7 cells by MTS assay
    Cytotoxicity activity against human MCF7 cells by MTS assay
    		[PMID: 21680064]
    RAW264.7 IC50
    18.5 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    		[PMID: 36242986]
    MCF7 IC50
    4 3
    Compound: TAM
    Cytotoxicity against human MCF7 Cells after 48 hrs by neutral red dye-based assay
    Cytotoxicity against human MCF7 Cells after 48 hrs by neutral red dye-based assay
    		[PMID: 31129455]
    SH-SY5Y IC50
    20 3
    Compound: Tamoxifen
    Inhibition of PKC in human SH-SY5Y cells assessed as inhibition of PMA-stimulated MARCKS phosphorylation preincubated for 1 hr followed by PMA-stimulation for 15 mins by Western blot analysis
    Inhibition of PKC in human SH-SY5Y cells assessed as inhibition of PMA-stimulated MARCKS phosphorylation preincubated for 1 hr followed by PMA-stimulation for 15 mins by Western blot analysis
    		[PMID: 27647375]
    MCF7 IC50
    4.1 3
    Compound: 2
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 25369367]
    MCF7 IC50
    4.1 3
    Compound: 2a
    Antiproliferative activity against ER-dependent human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against ER-dependent human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 28426931]
    MCF7 IC50
    4.1 3
    Compound: Tamoxifen
    Antiproliferative activity against ER-positive human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by AlamarBlue assay
    Antiproliferative activity against ER-positive human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by AlamarBlue assay
    		[PMID: 27407030]
    SK-BR-3 ED50
    5 6
    Compound: TAM
    Cytotoxicity against estrogen receptor deficient human SKBR3 cells overexpressing human epidermal growth factor receptor 2 after 72 hrs by SRB assay
    Cytotoxicity against estrogen receptor deficient human SKBR3 cells overexpressing human epidermal growth factor receptor 2 after 72 hrs by SRB assay
    		[PMID: 19425534]
    MCF7 IC50
    4.12 3
    Compound: 1a
    Antiproliferative activity against estrogen receptor dependent human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against estrogen receptor dependent human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 18835176]
    MCF7 IC50
    4.12 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
    		[PMID: 31987694]
    SK-BR-3 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER
    Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER
    		[PMID: 16942038]
    SK-BR-3 GI50
    12.5 3
    Compound: Tamoxifen
    Cytotoxicity against human SKBR3 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human SKBR3 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MCF7 IC50
    4.4 3
    Compound: 2a
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by SRB assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by SRB assay
    		[PMID: 28426931]
    MCF7 IC50
    4.4 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 26896706]
    SK-BR-3 IC50
    <1 2
    Compound: Tamoxifen
    Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    SK-BR-3 IC50
    28.32 3
    Compound: Tamoxifen
    Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
    Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MCF7 IC50
    4.67 3
    Compound: Tam
    Antiproliferative activity human ER-positive MCF7 cells after 2 days by MTT assay
    Antiproliferative activity human ER-positive MCF7 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MCF7 IC50
    42.4 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30731397]
    SK-MEL-28 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human SK-MEL-28 cells by alamar blue assay
    Cytotoxicity against human SK-MEL-28 cells by alamar blue assay
    		[PMID: 11720540]
    SK-OV-3 GI50
    6.4 3
    Compound: Tamoxifen
    Anticancer activity against human SKOV3 cells after 24 hrs by SRB assay
    Anticancer activity against human SKOV3 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    MCF7 IC50
    481 1
    Compound: 1 (tamoxifen)
    Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells
    Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells
    		[PMID: 9154963]
    SK-OV-3 GI50
    10 3
    Compound: TAM
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    5.09 3
    Compound: TAM
    Antiproliferative activity against MCF7 cells at 3 mg/kg/day after 48 hrs
    Antiproliferative activity against MCF7 cells at 3 mg/kg/day after 48 hrs
    		[PMID: 16979337]
    SNB-75 GI50
    5.01 3
    Compound: TAM
    Cytotoxicity against human SNB75 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human SNB75 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    5.19 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 23806014]
    MCF7 IC50
    5.3 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    T47D GI50
    10.6 3
    Compound: Tamoxifen
    Cytotoxicity against human T47D cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MCF7 IC50
    5.3 3
    Compound: Tamoxifen
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 29220789]
    T47D GI50
    1.99 3
    Compound: TAM
    Cytotoxicity against human T47D cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    5.4 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 34726897]
    T47D IC50
    0.1 3
    Compound: Tamoxifen
    Antiestrogenic activity in human T47D cells expressing estrogen receptor assessed as estrogen-dependent transcription by luciferase reporter gene assay
    Antiestrogenic activity in human T47D cells expressing estrogen receptor assessed as estrogen-dependent transcription by luciferase reporter gene assay
    		[PMID: 19131248]
    MCF7 IC50
    5.5 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    5.62 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 33894490]
    T47D IC50
    34.42 3
    Compound: Tamoxifen
    Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
    Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
    		[PMID: 30731397]
    T47D IC50
    13 3
    Compound: TAM
    Antiproliferative activity against human T47D cells after 48 hrs by MTT assay
    Antiproliferative activity against human T47D cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MCF7 IC50
    5.8 3
    Compound: Tamoxifen
    Induction of apoptosis in human MCF7 cells in presence of EGCG at 50 uM
    Induction of apoptosis in human MCF7 cells in presence of EGCG at 50 uM
    		[PMID: 36780831]
    T47D IC50
    14.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human T47D cells by MTT reduction assay
    Antiproliferative activity against human T47D cells by MTT reduction assay
    		[PMID: 33421712]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Cytotoxicity against human ER-positive MCF7 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human ER-positive MCF7 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26972118]
    T47D IC50
    12.1 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) T47D cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) T47D cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
    		[PMID: 36846377]
    T47D IC50
    1.13 3
    Compound: Tamoxifen
    Cytotoxicity against human T47D cells after 5 days
    Cytotoxicity against human T47D cells after 5 days
    		[PMID: 23864928]
    MCF7 IC50
    50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay
    		[PMID: 36846377]
    T47D IC50
    29.9 3
    Compound: Tam
    Cytotoxicity against human T47D cells expressing ER after 48 hrs by MTT assay
    Cytotoxicity against human T47D cells expressing ER after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MCF7 IC50
    54 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 33234343]
    T47D IC50
    1 3
    Compound: Tamoxifen
    Growth inhibition of human estrogen-dependent T47D cells after 72 hrs
    Growth inhibition of human estrogen-dependent T47D cells after 72 hrs
    		[PMID: 19131248]
    MCF7 IC50
    55.5 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MCF7 IC50
    580 1
    Compound: 3 (Tamoxifen)
    Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
    Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
    		[PMID: 12825935]
    THP-1 IC50
    11.91 3
    Compound: Tamoxifen
    Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    MCF7 IC50
    580 1
    Compound: tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay
    		[PMID: 18272256]
    MCF7 IC50
    6 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    UO-31 GI50
    6.3 3
    Compound: TAM
    Cytotoxicity against human UO31 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human UO31 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MCF7 IC50
    6.3 3
    Compound: Tamoxifen
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    MCF7 EC50
    >200 1
    Compound: 2
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by Cell-titer Glo assay
    Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by Cell-titer Glo assay
    		[PMID: 34251202]
    Vero IC50
    5.7 3
    Compound: Tamoxifen
    Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
    Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MCF7 IC50
    6.99 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by resazurin microplate assay
    Cytotoxicity against human MCF7 cells by resazurin microplate assay
    		[PMID: 27228159]
    Vero IC50
    15.9 3
    Compound: Tamoxifen
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    MCF7 IC50
    64.3 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    		[PMID: 25164760]
    Vero IC50
    36.2 3
    Compound: Tamoxifen
    Cytotoxicity against african green monkey Vero cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against african green monkey Vero cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MCF7 IC50
    7.09 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 30360952]
    MCF7 IC50
    7.1 3
    Compound: 2
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    MCF7 IC50
    7.65 3
    Compound: TAM
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 19740667]
    MCF7 IC50
    7.94 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 72 hrs by resazurin based fluorescence assay
    Cytotoxicity against human MCF7 cells after 72 hrs by resazurin based fluorescence assay
    		[PMID: 28927795]
    MCF7 IC50
    70 1
    Compound: Tamoxifen
    Inhibition of estrogen receptor positive MCF-7 breast cancer cell proliferation
    Inhibition of estrogen receptor positive MCF-7 breast cancer cell proliferation
    		[PMID: 14971899]
    MCF7 IC50
    8 3
    Compound: Tam Z
    Cytostaticity against MCF-7 cells in the presence of 1 uMolar E2 (estradiol)
    Cytostaticity against MCF-7 cells in the presence of 1 uMolar E2 (estradiol)
    		[PMID: 9089332]
    MCF7 IC50
    8.12 3
    Compound: TAM
    Antiproliferative activity against estrogen receptor positive human MCF7 cells assessed as inhibition of cell viability by MTT assay
    Antiproliferative activity against estrogen receptor positive human MCF7 cells assessed as inhibition of cell viability by MTT assay
    		[PMID: 38729318]
    MCF7 IC50
    8.12 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    MCF7 IC50
    8.31 6
    Compound: TAM
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 21115211]
    MCF7 IC50
    8.38 6
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells assessed a cell growth inhibition incubated for 48 hrs by SRB assay
    Anticancer activity against human MCF7 cells assessed a cell growth inhibition incubated for 48 hrs by SRB assay
    		[PMID: 32771798]
    MCF7 IC50
    8.42 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MCF7 IC50
    8.53 3
    Compound: 1
    Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    MCF7 IC50
    8.5 6
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 36325400]
    MCF7 IC50
    8.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS
    Cytotoxicity against human MCF7 cells after 72 hrs by WST1 assay in presence of 20% FBS
    		[PMID: 22901895]
    MCF7 IC50
    8.61 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
    		[PMID: 29605808]
    MCF7 IC50
    8.9 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    MCF7 IC50
    82.5 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25164760]
    MCF7 IC50
    8 6
    Compound: Tamoxifen
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
    		[PMID: 24576797]
    MCF7 IC50
    9 3
    Compound: TAM
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    MCF7 IC50
    9 3
    Compound: Tamoxifen
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
    		[PMID: 32731188]
    MCF7 IC50
    9.6 3
    Compound: Tamoxifen
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against ER and PR-positive human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    MCF7 IC50
    < 1000 3
    Compound: Tamoxifen
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MCF7S IC50
    7200 1
    Compound: 1a
    Inhibition of [3H]thymidine incorporation into MCF-7 cells
    Inhibition of [3H]thymidine incorporation into MCF-7 cells
    		[PMID: 1573630]
    MDA-MB-231 ED50
    8.5 6
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells lacking ER
    Cytotoxicity against human MDA-MB-231 cells lacking ER
    		[PMID: 16942038]
    MDA-MB-231 GI50
    0.12 3
    Compound: Tamoxifen
    Growth inhibition of human MDA-MB-231 cells
    Growth inhibition of human MDA-MB-231 cells
    		[PMID: 31605865]
    MDA-MB-231 GI50
    0.24 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells
    Cytotoxicity against human MDA-MB-231 cells
    		[PMID: 31200236]
    MDA-MB-231 GI50
    0.24 3
    Compound: Tamoxifen
    Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by SRB assay
    Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by SRB assay
    		[PMID: 36577217]
    MDA-MB-231 GI50
    0.24 3
    Compound: Tamoxifen
    Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by SRB assay
    Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by SRB assay
    		[PMID: 38911170]
    MDA-MB-231 GI50
    15.1 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    MDA-MB-231 GI50
    18.8 3
    Compound: Tamoxifen
    Growth inhibition of estrogen-independent human MDA-MB-231 cells
    Growth inhibition of estrogen-independent human MDA-MB-231 cells
    		[PMID: 23403084]
    MDA-MB-231 IC50
    0.66 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 20451380]
    MDA-MB-231 IC50
    10 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24457094]
    MDA-MB-231 IC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 20605470]
    MDA-MB-231 IC50
    10.11 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    MDA-MB-231 IC50
    11.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 31546197]
    MDA-MB-231 IC50
    11.4 3
    Compound: TAM
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    MDA-MB-231 IC50
    12.4 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    Cytotoxicity against human MDA-MB-231 cells by WST-1 assay
    		[PMID: 19836230]
    MDA-MB-231 IC50
    12.41 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    MDA-MB-231 IC50
    13.9 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
    		[PMID: 27176944]
    MDA-MB-231 IC50
    14 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    MDA-MB-231 IC50
    14.5 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells by MTT reduction assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT reduction assay
    		[PMID: 33421712]
    MDA-MB-231 IC50
    14.94 3
    Compound: 1
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 35276362]
    MDA-MB-231 IC50
    15.01 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
    		[PMID: 33894490]
    MDA-MB-231 IC50
    17 3
    Compound: Tamoxifen
    Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against ERalpha and ERbeta-deficient human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    MDA-MB-231 IC50
    17.9 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells
    Antiproliferative activity against human MDA-MB-231 cells
    		[PMID: 27155469]
    MDA-MB-231 IC50
    18.08 3
    Compound: Tamoxifen
    Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition of protein translation
    Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition of protein translation
    		[PMID: 30530174]
    MDA-MB-231 IC50
    18.48 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    MDA-MB-231 IC50
    18.9 3
    Compound: Tamoxifen
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells expressing estrogen receptor after 48 hrs by MTT assay
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells expressing estrogen receptor after 48 hrs by MTT assay
    		[PMID: 21871812]
    MDA-MB-231 IC50
    19 3
    Compound: Tamoxifen
    Inhibitory concentration against MDA-MB-231 (ER-) cell line using SRB assay
    Inhibitory concentration against MDA-MB-231 (ER-) cell line using SRB assay
    		[PMID: 12565971]
    MDA-MB-231 IC50
    20 3
    Compound: tamoxifene
    Antiproliferative activity against human estrogen receptor deficient MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human estrogen receptor deficient MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 19423356]
    MDA-MB-231 IC50
    24 3
    Compound: tamoxifen
    Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay
    Anticancer activity against estrogen-positive human MDA-MB-231 cells after 18 hrs by MTT assay
    		[PMID: 19446930]
    MDA-MB-231 IC50
    25 3
    Compound: 1; TMX
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth
    		[PMID: 37484572]
    MDA-MB-231 IC50
    25.1 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    MDA-MB-231 IC50
    25.575 3
    Compound: 1; TMX
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CVDK-8 method
    		[PMID: 37484572]
    MDA-MB-231 IC50
    25.9 3
    Compound: TMX
    Cytotoxicity against human MDA-MB-231 assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    Cytotoxicity against human MDA-MB-231 assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    		[PMID: 38020071]
    MDA-MB-231 IC50
    27 3
    Compound: Tam
    Cytotoxicity against human ER negative MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human ER negative MDA-MB-231 cells after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MDA-MB-231 IC50
    28 3
    Compound: Tamoxifen
    In vitro inhibition of estrogen receptor negative MDA-MD-231 human mammary carcinoma cell proliferation
    In vitro inhibition of estrogen receptor negative MDA-MD-231 human mammary carcinoma cell proliferation
    		10.1016/0960-894X(95)00381-3
    MDA-MB-231 IC50
    30.848 3
    Compound: 1; TMX
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by CVDK-8 method
    		[PMID: 37484572]
    MDA-MB-231 IC50
    35.8 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    MDA-MB-231 IC50
    38.97 3
    Compound: Tam
    Antiproliferative activity human ER-negative MDA-MB-231 cells after 2 days by MTT assay
    Antiproliferative activity human ER-negative MDA-MB-231 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MDA-MB-231 IC50
    47.1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 30360952]
    MDA-MB-231 IC50
    5.9 3
    Compound: Tamoxifen
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in colony formation incubated for 7 days by crystal violet staining based assay
    		[PMID: 33373820]
    MDA-MB-231 IC50
    64.85 3
    Compound: 1, TAM
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 23860592]
    MDA-MB-231 IC50
    69.7 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
    		[PMID: 33139111]
    MDA-MB-231 IC50
    7 3
    Compound: Tamoxifen
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against ER-negative human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 33373820]
    MDA-MB-231 IC50
    7.85 6
    Compound: Tamoxifen
    Inhibition of estradiol-induced proliferation in human MDA-MB-231 cells after 72 hrs by Cell-titer-Glo assay
    Inhibition of estradiol-induced proliferation in human MDA-MB-231 cells after 72 hrs by Cell-titer-Glo assay
    		[PMID: 28442256]
    MDA-MB-231 IC50
    75 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 96 hrs by MTT assay
    		[PMID: 25164760]
    MDA-MB-231 IC50
    75 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
    		[PMID: 33234343]
    MDA-MB-231 IC50
    80 1
    Compound: Tamoxifen
    Inhibition of estrogen receptor negative MDA-MB-231 breast cancer cell proliferation
    Inhibition of estrogen receptor negative MDA-MB-231 breast cancer cell proliferation
    		[PMID: 14971899]
    MDA-MB-231 IC50
    84.6 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 25164760]
    MDA-MB-231 IC50
    9.86 3
    Compound: TAM
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 19740667]
    MDA-MB-231 IC50
    9.96 3
    Compound: TAM
    Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay
    Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay
    		[PMID: 38729318]
    MDA-MB-231 IC50
    9.96 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 29054359]
    MDA-MB-231 IC50
    < 1000 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    MDA-MB-231 IC50
    > 20 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    MDA-MB-231 IC50
    > 50 3
    Compound: Tamoxifen
    Cytotoxicity against human ER-negative MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human ER-negative MDA-MB-231 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26972118]
    MDA-MB-231 IC50
    > 50 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay
    		[PMID: 34022716]
    MDA-MB-435 GI50
    3.16 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MDA-MB-435 IC50
    0.1 3
    Compound: Tamoxifen
    Antiproliferative activity against human MDA-MB-435 cells
    Antiproliferative activity against human MDA-MB-435 cells
    		[PMID: 33421712]
    MDA-MB-435 IC50
    50 1
    Compound: Tamoxifen
    Inhibition of MDA-MB-435 breast cancer cell proliferation
    Inhibition of MDA-MB-435 breast cancer cell proliferation
    		[PMID: 14971899]
    MDA-MB-435S IC50
    5.5 3
    Compound: Tamoxifen
    Cytotoxicity against human MDA-MB-435S cells assessed as cell viability by MTT assay
    Cytotoxicity against human MDA-MB-435S cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    MDA-MB-436 IC50
    15.8 3
    Compound: TMX
    Cytotoxicity against human MDA-MB-436 assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    Cytotoxicity against human MDA-MB-436 assessed as reduction in cell viability measured after 48 hrs by WST-1 assay
    		[PMID: 38020071]
    MDA-MB-453 IC50
    > 5 3
    Compound: tamoxifen (TAM)
    Inhibition of estrogen receptor negative MDA-MB-453 breast cancer cell proliferation with 10e-4 M estradiol
    Inhibition of estrogen receptor negative MDA-MB-453 breast cancer cell proliferation with 10e-4 M estradiol
    		[PMID: 8784443]
    MDA-MB-468 GI50
    2.5 3
    Compound: TAM
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MDA-MB-468 IC50
    14.99 3
    Compound: Tam
    Cytotoxicity against human ER negative MDA-MB-468 cells after 48 hrs by MTT assay
    Cytotoxicity against human ER negative MDA-MB-468 cells after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    MEL-JUSO EC50
    14.6 3
    Compound: TAM
    Antiproliferative activity against human MelJuSo cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    Antiproliferative activity against human MelJuSo cells assessed as reduction in cell viability measured after 24 hrs by celltiter-blue assay
    		[PMID: 31099568]
    MIA PaCa-2 IC50
    33.12 3
    Compound: Tam
    Antiproliferative activity human MIAPaCa2 cells after 2 days by MTT assay
    Antiproliferative activity human MIAPaCa2 cells after 2 days by MTT assay
    		[PMID: 25222876]
    MOLT-4 GI50
    2.5 3
    Compound: TAM
    Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human MOLT4 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    MRC5 CC50
    10 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells measured after 7 days by MTT assay
    Cytotoxicity against human MRC5 cells measured after 7 days by MTT assay
    		[PMID: 33667089]
    MRC5 CC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based fluorimetric assay
    Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based fluorimetric assay
    		[PMID: 30857749]
    MRC5 IC50
    10.9 3
    Compound: TAM
    Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
    Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
    		[PMID: 26922226]
    MRC5 IC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells after 24 hrs by resazurin dye based assay
    Cytotoxicity against human MRC5 cells after 24 hrs by resazurin dye based assay
    		[PMID: 30692024]
    MRC5 IC50
    11.09 3
    Compound: Tamoxifen
    Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
    Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
    		[PMID: 30879839]
    MRC5 IC50
    17.2 3
    Compound: Tamoxifen
    Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    		[PMID: 36242986]
    MSTO-211H GI50
    23.3 3
    Compound: 1
    Antiproliferative activity against human MSTO-211H cells after 72 hrs by trypan blue assay
    Antiproliferative activity against human MSTO-211H cells after 72 hrs by trypan blue assay
    		[PMID: 23735829]
    MVLN IC50
    0.3 3
    Compound: Tam Z
    Anti-estrogenicity for 50% inhibition of the MVLN cell luciferase activity due to 0.1 nM E2 (estradiol)
    Anti-estrogenicity for 50% inhibition of the MVLN cell luciferase activity due to 0.1 nM E2 (estradiol)
    		[PMID: 9089332]
    NCI-H460 GI50
    4.48 3
    Compound: Tamoxifen
    Anticancer activity against human NCI-H460 cells after 24 hrs by SRB assay
    Anticancer activity against human NCI-H460 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    NCI/ADR-RES IC50
    11.13 3
    Compound: Tamoxifen
    Cytotoxicity against human MCF7/ADR cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7/ADR cells after 48 hrs by MTT assay
    		[PMID: 23022281]
    NCI/ADR-RES IC50
    2000 1
    Compound: Tamoxifen
    Inhibition of MCF-7/Adr breast cancer cell proliferation
    Inhibition of MCF-7/Adr breast cancer cell proliferation
    		[PMID: 14971899]
    NIH-3T3-G185 IC50
    12.1 3
    Compound: Tamoxifen
    TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells
    TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells
    		[PMID: 11716514]
    NIH-3T3-G185 IC50
    31.4 3
    Compound: Tamoxifen
    TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells
    TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells
    		[PMID: 11716514]
    NIH-3T3-G185 IC50
    6.4 3
    Compound: Tamoxifen
    TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
    TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
    		[PMID: 11716514]
    NIH3T3 IC50
    10.66 6
    Compound: Tamoxifen
    Phototoxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability preincubated for 1 hr followed by 5 J/cm2 irradiation and subsequent replacement of medium without compound and measured after 24 hrs by neutral red dye based assay
    Phototoxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability preincubated for 1 hr followed by 5 J/cm2 irradiation and subsequent replacement of medium without compound and measured after 24 hrs by neutral red dye based assay
    		[PMID: 38128906]
    NIH3T3 IC50
    11.4 3
    Compound: TAM
    Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    NIH3T3 IC50
    13.03 6
    Compound: Tamoxifen
    Dark toxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability incubated for 1 hr by neutral red dye based assay
    Dark toxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability incubated for 1 hr by neutral red dye based assay
    		[PMID: 38128906]
    NIH3T3 IC50
    7.26 3
    Compound: 2
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    NIH3T3 IC50
    > 100 3
    Compound: Tam
    Antiproliferative activity mouse NIH/3T3 cells after 2 days by MTT assay
    Antiproliferative activity mouse NIH/3T3 cells after 2 days by MTT assay
    		[PMID: 25222876]
    OVCAR-5 GI50
    32 3
    Compound: 1
    Cytotoxicity against human OVCAR5 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    Cytotoxicity against human OVCAR5 cells assessed as cell growth inhibition after 72 hrs by MTS assay
    		[PMID: 27128175]
    PANC-1 GI50
    0.12 3
    Compound: Tamoxifen
    Growth inhibition of human PANC1 cells
    Growth inhibition of human PANC1 cells
    		[PMID: 31605865]
    PANC-1 GI50
    0.15 3
    Compound: Tamoxifen
    Cytotoxicity against human PANC1 cells
    Cytotoxicity against human PANC1 cells
    		[PMID: 31200236]
    PC-3 IC50
    10 3
    Compound: TAM
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    PC-3 IC50
    15.8 3
    Compound: TAM
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 34153643]
    PC-3 IC50
    7 3
    Compound: Tamoxifen
    Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
    Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
    		[PMID: 24880230]
    PC-3 IC50
    > 1000 1
    Compound: 7
    Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
    		[PMID: 33479633]
    PC-3 IC50
    > 40 3
    Compound: Tamoxifen
    Antiproliferative activity against human PC3 cells
    Antiproliferative activity against human PC3 cells
    		[PMID: 27155469]
    RAW264.7 CC50
    11.1 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by neutral red dye based assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by neutral red dye based assay
    		[PMID: 31703818]
    RAW264.7 CC50
    5.03 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction of cell viability incubated for 72 hrs by Cell Titer-Glo assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction of cell viability incubated for 72 hrs by Cell Titer-Glo assay
    		[PMID: 37871508]
    RAW264.7 IC50
    18.5 3
    Compound: Tamoxifen
    Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
    		[PMID: 36242986]
    SH-SY5Y IC50
    20 3
    Compound: Tamoxifen
    Inhibition of PKC in human SH-SY5Y cells assessed as inhibition of PMA-stimulated MARCKS phosphorylation preincubated for 1 hr followed by PMA-stimulation for 15 mins by Western blot analysis
    Inhibition of PKC in human SH-SY5Y cells assessed as inhibition of PMA-stimulated MARCKS phosphorylation preincubated for 1 hr followed by PMA-stimulation for 15 mins by Western blot analysis
    		[PMID: 27647375]
    SK-BR-3 ED50
    5 6
    Compound: TAM
    Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER
    Cytotoxicity against human SK-BR-3 cells expressing HER2 and lacking ER
    		[PMID: 16942038]
    SK-BR-3 ED50
    5 6
    Compound: TAM
    Cytotoxicity against estrogen receptor deficient human SKBR3 cells overexpressing human epidermal growth factor receptor 2 after 72 hrs by SRB assay
    Cytotoxicity against estrogen receptor deficient human SKBR3 cells overexpressing human epidermal growth factor receptor 2 after 72 hrs by SRB assay
    		[PMID: 19425534]
    SK-BR-3 GI50
    12.5 3
    Compound: Tamoxifen
    Cytotoxicity against human SKBR3 cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human SKBR3 cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    SK-BR-3 IC50
    28.32 3
    Compound: Tamoxifen
    Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
    Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay
    		[PMID: 33340662]
    SK-BR-3 IC50
    < 1000 3
    Compound: Tamoxifen
    Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst 33342/propidium iodide staining based fluorescence analysis
    		[PMID: 36603398]
    SK-MEL-28 IC50
    1.86 6
    Compound: Tomoxifen
    Cytotoxicity against human SK-MEL-28 cells by alamar blue assay
    Cytotoxicity against human SK-MEL-28 cells by alamar blue assay
    		[PMID: 11720540]
    SK-OV-3 GI50
    10 3
    Compound: TAM
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    SK-OV-3 GI50
    6.4 3
    Compound: Tamoxifen
    Anticancer activity against human SKOV3 cells after 24 hrs by SRB assay
    Anticancer activity against human SKOV3 cells after 24 hrs by SRB assay
    		[PMID: 19733085]
    SNB-75 GI50
    5.01 3
    Compound: TAM
    Cytotoxicity against human SNB75 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human SNB75 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    SW-620 ED50
    4 6
    Compound: TAM
    Cytotoxicity against human SW620 cells
    Cytotoxicity against human SW620 cells
    		[PMID: 16942038]
    SiHa GI50
    0.12 3
    Compound: Tamoxifen
    Cytotoxicity against human SiHa cells
    Cytotoxicity against human SiHa cells
    		[PMID: 31200236]
    SiHa GI50
    0.12 3
    Compound: Tamoxifen
    Growth inhibition of human SiHa cells
    Growth inhibition of human SiHa cells
    		[PMID: 31605865]
    SiHa GI50
    0.12 3
    Compound: Tamoxifen
    Growth inhibition of human SiHa cells measured after 48 hrs by SRB assay
    Growth inhibition of human SiHa cells measured after 48 hrs by SRB assay
    		[PMID: 36577217]
    T47D GI50
    1.99 3
    Compound: TAM
    Cytotoxicity against human T47D cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    T47D GI50
    10.6 3
    Compound: Tamoxifen
    Cytotoxicity against human T47D cells assessed as growth inhibition after 120 hrs by MTT assay
    Cytotoxicity against human T47D cells assessed as growth inhibition after 120 hrs by MTT assay
    		[PMID: 28152429]
    T47D IC50
    0.1 3
    Compound: Tamoxifen
    Antiestrogenic activity in human T47D cells expressing estrogen receptor assessed as estrogen-dependent transcription by luciferase reporter gene assay
    Antiestrogenic activity in human T47D cells expressing estrogen receptor assessed as estrogen-dependent transcription by luciferase reporter gene assay
    		[PMID: 19131248]
    T47D IC50
    1 3
    Compound: Tamoxifen
    Growth inhibition of human estrogen-dependent T47D cells after 72 hrs
    Growth inhibition of human estrogen-dependent T47D cells after 72 hrs
    		[PMID: 19131248]
    T47D IC50
    1.13 3
    Compound: Tamoxifen
    Cytotoxicity against human T47D cells after 5 days
    Cytotoxicity against human T47D cells after 5 days
    		[PMID: 23864928]
    T47D IC50
    12.1 3
    Compound: Tamoxifen
    Cytotoxicity against Homo sapiens (human) T47D cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) T47D cells assessed as inhibition of cell proliferation after 72 hr by MTT assay
    		10.1007/s00044-012-0391-5
    T47D IC50
    13 3
    Compound: TAM
    Antiproliferative activity against human T47D cells after 48 hrs by MTT assay
    Antiproliferative activity against human T47D cells after 48 hrs by MTT assay
    		[PMID: 23287057]
    T47D IC50
    14.2 3
    Compound: Tamoxifen
    Antiproliferative activity against human T47D cells by MTT reduction assay
    Antiproliferative activity against human T47D cells by MTT reduction assay
    		[PMID: 33421712]
    T47D IC50
    29.9 3
    Compound: Tam
    Cytotoxicity against human T47D cells expressing ER after 48 hrs by MTT assay
    Cytotoxicity against human T47D cells expressing ER after 48 hrs by MTT assay
    		10.1039/C4MD00289J
    T47D IC50
    34.42 3
    Compound: Tamoxifen
    Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
    Antiproliferative activity against human T47D cells after 24 hrs by MTT assay
    		[PMID: 30731397]
    THP-1 IC50
    11.91 3
    Compound: Tamoxifen
    Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay
    		[PMID: 31884407]
    UO-31 GI50
    6.3 3
    Compound: TAM
    Cytotoxicity against human UO31 cells assessed as growth inhibition after 48 hrs by SRB assay
    Cytotoxicity against human UO31 cells assessed as growth inhibition after 48 hrs by SRB assay
    		[PMID: 26896706]
    Vero IC50
    15.9 3
    Compound: Tamoxifen
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23786452]
    Vero IC50
    36.2 3
    Compound: Tamoxifen
    Cytotoxicity against african green monkey Vero cells incubated for 72 hrs by Sulphorhodamine assay
    Cytotoxicity against african green monkey Vero cells incubated for 72 hrs by Sulphorhodamine assay
    		[PMID: 37146520]
    Vero IC50
    5.7 3
    Compound: Tamoxifen
    Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
    Cytotoxicity against African green monkey Vero cells assessed as cell viability by MTT assay
    		[PMID: 26079090]
    ZR-75-1 ED50
    3.6 6
    Compound: TAM
    Cytotoxicity against human ZR-75-1 cells expressing ER
    Cytotoxicity against human ZR-75-1 cells expressing ER
    		[PMID: 16942038]
    In Vitro

    Tamoxifen (ICI 47699) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Tamoxifen Related Antibodies
    Parmacokinetics
    Species Dose Route AUC0-∞ Cmax Half-life Tmax T1/2 Bioavailability
    Mice[12] 10 mg/kg p.o. 25.1 ng/mL·h 11.4 ng/mL 2.0 h 0.5 h / /
    Mice[12] 10 mg/kg s.c. 363 ng/mL·h 43.4 ng/mL 6.8 h 1.0 h / /
    Mice[12] 20 mg/kg p.o. 104 ng/mL·h 40.8 ng/mL 7.6 h 1.0 h / /
    Mice[12] 20 mg/kg s.c. 769 ng/mL·h 49.4 ng/mL 11.2 h 4.0 h / /
    Mice[12] 4 mg/kg p.o. 3.8 ng/mL·h 1.7 ng/mL 1.0 h 1.0 h / /
    Mice[12] 4 mg/kg s.c. 152 ng/mL·h 20.5 ng/mL 7.7 h 2.0 h / /
    Rat[13] 10 mg/kg p.o. 2060 ng/mL·h 126 ng/mL / 1.17 h 11.2 h 22.2 (absolute) %
    Rat[13] 2 mg/kg i.v. 1860 ng/mL·h / / / 9.0 h 100 (absolute) %
    In Vivo

    Note: Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    1. Induction of gene knockout[8][9]
    Background
    Gene knockout model induced by Tamoxifen uses Cre-Loxp mice. The Cre recombinase in these mice is driven by a tissue/cell-specific promoter, and the target gene is flanked by Loxp sites. The Cre recombinase is fused with the ligand-binding domain of the estrogen receptor to construct a Cre-ER fusion protein, and the recombination activity of Cre is induced by Tamoxifen. In the absence of Tamoxifen, the Cre-ER fusion protein binds to HSP90 and remains in the cytoplasm. After Tamoxifen induction, the metabolite of Tamoxifen, 4-OHT, binds to the Cre-ER protein, activates the Cre recombinase, and allows it to enter the nucleus. There, it recognizes the Loxp sites and mediates the knockout of the gene between two (in the same orientation) Loxp sites. (To avoid interference from endogenous estrogens, the ligand-binding domain of the estrogen receptor is modified, transforming Cre-ER into MerCreMer, Cre-ERT, or Cre-ERT2).
    Specific Modeling Methods
    Cx3cr1CreERT/+: Pdgfbfl/fl mice (Conditional knockout of Pdgfb in microglia)
    Administration: 75 mg/kg • i.p. • once daily for 5 days
    Note
    (1) Dissolution: Tamoxifen is poorly soluble in water and is generally dissolved in Corn oil (HY-Y1888). It can be heated at 37°C or sonicated to assist dissolution, ensuring complete dissolution. Tamoxifen should be prepared in the dark and is recommended to be used freshly prepared. Corn oil is relatively viscous. When aspirating the solution, the needle can be left unplugged. After aspirating the solution, attach the needle and expel the air bubbles.
    (2) Administration methods: Common methods include intraperitoneal injection, and it can also be administered by oral gavage or subcutaneous injection. When performing multiple intraperitoneal injections, the injection sites should be alternated.
    (3) Dosage: The dosage is 50-120 mg/kg, with 3-5 intraperitoneal injections, usually for 5 consecutive days. The dosage for pregnant mice and aged mice (over 6 months old) should be appropriately reduced. Tamoxifen can affect fetal development and parturition. For pregnant mice, the induction time should preferably be selected in the late pregnancy stage, and progesterone should be injected simultaneously to reduce the probability of miscarriage.
    (4) Mice: Mice at 4-6 weeks old may be more sensitive (it is more effective in young mice than in old mice).
    (5) Potential toxicity: Prolonged high-level Cre activity can cause potential toxicity. In addition, if an important functional gene is knocked out or using Homozygous Mice, it may also lead to the death of mice. Therefore, close observation should be carried out within one or two weeks after induction. If the mice show abnormalities, the causes need to be analyzed in a timely manner and the experimental plan should be adjusted.
    (6) Control: Control group mice should be injected with an equal amount of the corn oil solution of Tamoxifen (using Tamoxifen in a genetic background without Cre recombinase) to rule out the influence of Tamoxifen itself.
    (7) Detection window: The time window between Tamoxifen administration and the start of the experiment should be large enough, at least 7 days, to ensure that the Cre recombinase enters the nucleus and functions.
    (8) Separate caging: Animals treated with Tamoxifen should be caged separately from untreated animals to avoid cross - contamination caused by behaviors such as animals licking the oily Tamoxifen suspension, grooming their fur, or coprophagy.
    Modeling Indicators
    Verify the reduced expression/knockout of the target gene at the RNA or protein level through molecular biology and genetic methods (such as Western blot, PCR, and sequencing, etc.).
    Correlated Product(s): 4-Hydroxytamoxifen (HY-16950)
    2. Induction of liver injury[10][11]
    Background
    Tamoxifen reduces the hexose monophosphate shunt, thereby increasing the incidence of oxidative stress in rat hepatocytes, leading to liver injury.
    Specific Modeling Methods
    Albino rat • female
    Administration: 45 mg/kg • i.p. • once daily for 7 days
    Note
    (1) The rats were kept in a standard laboratory environment, which was a 12-hour light/12-hour dark cycle with the temperature maintained at 25 ± 2°C. They had free access to food and water.
    (2) At the end of the experiment, the animals were euthanized by cervical dislocation under mild ether anesthesia. The blood samples were collected in heparinized centrifuge tubes and centrifuged to obtain serum. The abdomen was opened, and the liver was immediately dissected and removed. It was washed with ice-cold isotonic saline and blotted between two filter papers. The liver was wrapped in aluminum foil and stored at -80°C. A 10% (w/v) liver homogenate was prepared in ice-cold 0.1 M potassium phosphate buffer (pH 7.5) using an ultrasonicator.
    Modeling Indicators
    Molecular Changes: The activities of antioxidant enzymes, including glutathione S-transferase, glutathione peroxidase, and catalase, were significantly ↓, while the content of reduced glutathione also showed a ↓ trend. Concurrently, the levels of thiobarbituric acid reactive substances (TBARS) and liver transaminases, including serum glutamic-pyruvic transaminase (sGPT) and serum glutamic-oxaloacetic transaminase (sGOT), were significantly ↑.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Essai clinique
    Masse moléculaire

    371.51

    Formule

    C26H29NO
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCN(C)C
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvant et solubilité
    In Vitro: 

    Ethanol : 50 mg/mL (134.59 mM; Need ultrasonic)

    DMSO : 13.46 mg/mL (36.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6917 mL 13.4586 mL 26.9172 mL
    5 mM 0.5383 mL 2.6917 mL 5.3834 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 1.39 mg/mL (3.74 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.39 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.9 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  Corn Oil

      Solubility: 20 mg/mL (53.83 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureté et documentation

    Purity: 99.96%

    SDS (701 KB)

    COA (248 KB) HNMR (267 KB) RP-HPLC (244 KB) LCMS (103 KB)

    Instruction de manipulation (2659 KB)
    Références
    Administration animale
    [3]

    Mice[3]
    Seven-week old TmcsMed1-/- mice and the wild-type littermates are then administered Tamoxifen intraperitoneally at a daily dose of 65 mg/kg body weight for 5 days and then killed at selected intervals after initiation of Tamoxifen treatment. For each experiment 3 to 5 mice for control and csMed1-/- are used. To obtain survival curve 41 csMed1-/- and 41 csMed1fl/fl mice are used. Thirteen TmcsMed-/- mice and the same number of littermates are used for the survival curve experiments using Tamoxifen inducible model. The specific criteria for animal euthanasia included absence of food or water intake, slow or no mobility, weak or absence of heart beat, absence of palpitation of the chest as well as absence of respiratory movement.

    MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / Ethanol 1 mM 2.6917 mL 13.4586 mL 26.9172 mL 67.2929 mL
    5 mM 0.5383 mL 2.6917 mL 5.3834 mL 13.4586 mL
    10 mM 0.2692 mL 1.3459 mL 2.6917 mL 6.7293 mL
    15 mM 0.1794 mL 0.8972 mL 1.7945 mL 4.4862 mL
    20 mM 0.1346 mL 0.6729 mL 1.3459 mL 3.3646 mL
    25 mM 0.1077 mL 0.5383 mL 1.0767 mL 2.6917 mL
    30 mM 0.0897 mL 0.4486 mL 0.8972 mL 2.2431 mL
    Ethanol 40 mM 0.0673 mL 0.3365 mL 0.6729 mL 1.6823 mL
    50 mM 0.0538 mL 0.2692 mL 0.5383 mL 1.3459 mL
    60 mM 0.0449 mL 0.2243 mL 0.4486 mL 1.1215 mL
    80 mM 0.0336 mL 0.1682 mL 0.3365 mL 0.8412 mL
    100 mM 0.0269 mL 0.1346 mL 0.2692 mL 0.6729 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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