2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. alpha-Bisabolol

alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities.

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alpha-Bisabolol

alpha-Bisabolol 構造式

CAS 番号 : 515-69-5

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Liquid
1 g $30 在庫あり
5 g $60 在庫あり
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50 g   お問い合わせ  

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alpha-Bisabolol 関連抗体

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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製品説明

alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities[1][2].

IC50 & Target[1]

PI3K

 

体外実験

alpha-Bisabolol (3.2-120 µM; 24 h) exerts antiproliferative effects on A549 cells[1].
alpha-Bisabolol (7.5-30 µM; 24 h) caused apoptosis in A549 cells in a concentration-dependent manner[1].
alpha-Bisabolol (7.5-30 µM; 24 h) induces G2/M cell cycle arrest of A549 cells[1].
alpha-Bisabolol (15 µM; 24 h) reduces the motility and migration of the of A549 cells in a dose-dependent manner[1].
alpha-Bisabolol (15 µM; 24 h) exhibits a dose-dependent downregulation of p-PI3K and p-AKT proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

alpha-Bisabolol 関連抗体

Cell Viability Assay[1]

Cell Line: A549 NSCLC cell line
Concentration: 3.2, 7.5, 15, 30, 60, 120 µM
Incubation Time: 24 h
Result: Displayed significant anticancer effects against A549 cells with an observed IC50 15 µM.

Apoptosis Analysis[1]

Cell Line: A549 NSCLC cell line
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 h
Result: The percentage of apoptotic cells increased from 2.15% in the control to 48.5% at 30 µM concentration.

Cell Cycle Analysis[1]

Cell Line: A549 NSCLC cell line
Concentration: 7.5, 15, 30 µM
Incubation Time: 24 h
Result: The number of cells at G2 phase increased in a dose-dependent manner causing cell cycle arrest.

Cell Migration Assay [1]

Cell Line: A549 NSCLC cell line
Concentration: 15 µM
Incubation Time: 24 h
Result: Reduced the motility and migration of the of A549 cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: A549 NSCLC cell line
Concentration: 15 µM
Incubation Time: 24 h
Result: Exhibited a dose-dependent downregulation of p-PI3K and p-AKT proteins.
体内実験

reduces the Cisplatin (HY-17394)-induced renal DNA damage, and markedly lessened the acute tubular necrosis observed in kidney histology[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female BALB/c mice weighing 25-30 g[1]
Dosage: 25 mg/kg
Administration: Orally; daily; for 7 days; continued for 3 more days
Result: Had significantly normalized the alterations of water intake, urine volume, relative kidney weight, and the concentrations of urea and creatinine, as well as the creatinine clearance induced by Cisplatin (CP; 20 mg/kg; ip; On day 7).
Significantly reduced the CP-induced renal DNA damage, and markedly lessened the acute tubular necrosis observed in kidney histology.
分子量

222.37

分子式

C15H26O
CAS 番号
Appearance

Liquid (Density: 0.93 g/cm3)

Color

Colorless to light yellow

SMILES

C/C(C)=C\CC[C@@](O)([C@@H]1CCC(C)=CC1)C
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (449.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4970 mL 22.4850 mL 44.9701 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL
10 mM 0.4497 mL 2.2485 mL 4.4970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
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% 
+
%
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%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 80.0%

COA (244 KB) HNMR (262 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4970 mL 22.4850 mL 44.9701 mL 112.4252 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL 22.4850 mL
10 mM 0.4497 mL 2.2485 mL 4.4970 mL 11.2425 mL
15 mM 0.2998 mL 1.4990 mL 2.9980 mL 7.4950 mL
20 mM 0.2249 mL 1.1243 mL 2.2485 mL 5.6213 mL
25 mM 0.1799 mL 0.8994 mL 1.7988 mL 4.4970 mL
30 mM 0.1499 mL 0.7495 mL 1.4990 mL 3.7475 mL
40 mM 0.1124 mL 0.5621 mL 1.1243 mL 2.8106 mL
50 mM 0.0899 mL 0.4497 mL 0.8994 mL 2.2485 mL
60 mM 0.0750 mL 0.3748 mL 0.7495 mL 1.8738 mL
80 mM 0.0562 mL 0.2811 mL 0.5621 mL 1.4053 mL
100 mM 0.0450 mL 0.2249 mL 0.4497 mL 1.1243 mL
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alpha-Bisabolol Related Classifications

  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

alpha-Bisabolol515-69-5PI3KApoptosisPhosphoinositide 3-kinasesesquiterpene alcoholcell cycle arrestmitochondrial apoptosisnephrotoxicityoxidative stressanti-inflammatoryanalgesicantibioticanticancerInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-121222
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