515-69-5
Chemical Structure
alpha-Bisabolol
- CAS No.: 515-69-5
- Formula:C15H26O
- Molecular Weight:222.37
IUPAC Name: (R)-6-methyl-2-((R)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
InChIKey: RGZSQWQPBWRIAQ-LSDHHAIUSA-N
SMILES: C/C(C)=C\CC[C@@](O)([C@@H]1CCC(C)=CC1)C
Biological Activity: alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities[1][2].
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alpha-Bisabolol | 80.0% | alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities. | ||||||||||||||||||||
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References
- [1]. Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23(5):1407-1412. [Content Brief]
- [2]. Nur Elena Zaaba, et al. The Nephroprotective Effects of α-Bisabolol in Cisplatin-Induced Acute Kidney Injury in Mice. Biomedicines. 2022 Apr 3;10(4):842. [Content Brief]
