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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
56 Results for "
14-3-3 protein
" in MedChemExpress (MCE) Product Catalog:
Products (56)
56 Results for "14-3-3 protein" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a KD of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .
1
Target:
1
Cat. No.: HY-115501
CAS No.: 1370281-06-3
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(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research .
Cat. No.: HY-177590
CAS No.: 919751-10-3
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14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC50 of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels .
Cat. No.: HY-P1380A
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Cat. No.: HY-158405
CAS No.: 2923674-83-1
Synonyms: MAV-104
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Research Areas:
PAV-104 (MAV-104) is a host-targeted, pan-respiratory viral assembly inhibitor. PAV-104 targets a small subset of the host protein 14-3-3 within a transient multi-protein complex. PAV-104 inhibits SARS-CoV-2 replication by blocking post-entry viral assembly/budding through interaction with viral nucleocapsid (N) protein and interference with its oligomerization. PAV-104 is orally active in cats and shows favorable pharmacokinetic properties in rats. PAV-104 can be used for the study of COVID-19 and other respiratory viral infections, including Feline Infectious Peritonitis (FIP) .
Cat. No.: HY-169905
CAS No.: 271798-59-5
Research Areas:
GR-14-3-3 stabilizer-1 is a molecular glue stabilizer for the protein-protein interaction between 14‑3‑3 and glucocorticoid receptor (GR), and functions by stabilizing the GR‑14‑3‑3 protein-protein interaction. GR-14-3-3 stabilizer-1 is applicable to research related to diseases such as tumors .
Cat. No.: HY-169081
Research Areas:
QS-57 is a heterobifunctional targeted protein localization (TPL) agent. QS-57 binds to BRD4 via its JQ1 domain and covalently targets 14-3-3σ to form a ternary complex. QS-57 sequesters nuclear BRD4 in the cytoplasm, impairing the nuclear transcriptional regulatory function mediated by BRD4. QS-57 significantly reduces the nuclear BRD4 protein level and increases the cytoplasmic BRD4 protein abundance in cancer cells. QS-57 can be used for research on breast cancer and colorectal cancer .
Cat. No.: HY-161611
14-3-3-IN-1 (Compound 2) is an inhibitor for 14-3-3 proteins in Arabidopsis thaliana, with an IC50 of 1.21 μM. 14-3-3-IN-1 exhibits different inhibitory activities against different 14-3-3 isomers. 14-3-3-IN-1 promotes the closure of stomata on leaves .
Cat. No.: HY-N13798
CAS No.: 138870-97-0
Cat. No.: HY-P75548A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: YWHAQ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein Theta; 14-3-3; HS1; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein; Theta Polypeptide; 14-3-3 protein T-Cell; 14-3-3 protein Theta; 14-3-3 protein Tau; P
Species:
Human
Source:
E. coli
Cat. No.: HY-P75548
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: YWHAQ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein Theta; 14-3-3; HS1; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein; Theta Polypeptide; 14-3-3 protein T-Cell; 14-3-3 protein Theta; 14-3-3 protein Tau; P
Species:
Human
Source:
E. coli
Cat. No.: HY-P703012
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YWHAQ; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein Theta; 14-3-3; HS1; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein; Theta Polypeptide; 14-3-3 protein T-Cell; 14-3-3 protein Theta; 14-3-3 protein Tau; protein
Species:
Mouse
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
