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  2. Difopein (TFA)

Difopein (TFA) 

Cat. No.: HY-P1380A
Handling Instructions

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.

For research use only. We do not sell to patients.

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Difopein (TFA) Chemical Structure

Difopein (TFA) Chemical Structure

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Description

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells[1].

IC50 & Target

14-3-3 protein[1]

Molecular Weight

6501.19

Formula

C₂₇₅H₄₂₅N₇₆F₃O₉₁S₆

Sequence

{Ser}{Ala}{Asp}{Gly}{Ala}{Pro}{His}{Cys}{Val}{Pro}{Arg}{Asp}{Leu}{Ser}{Trp}{Leu}{Asp}{Leu}{Glu}{Ala}{Asn}{Met}{Cys}{Leu}{Pro}{Gly}{Ala}{Ala}{Gly}{Leu}{Asp}{Ser}{Ala}{Asp}{Gly}{Ala}{Pro}{His}{Cys}{Val}{Pro}{Arg}{Asp}{Leu}{Ser}{Trp}{Leu}{Asp}{Leu}{Glu}{Ala}{Asn}{Met}{Cys}{Leu}{Pro}{Gly}{Ala}{Ala}{Gly}{Leu}{Glu}

Sequence Shortening

SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Difopein (TFA)
Cat. No.:
HY-P1380A
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