CLR01 sodium
CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1. CLR01 sodium reduces amyloid plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).
For research use only. We do not sell to patients.
- CAS No.: 1338489-62-5
- Formula: C42H30Na2O8P2
- Molecular Weight:770.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CLR01 binds the N-terminal lysine of the KLVFF peptide with a Kd of 10 μM in PBS buffer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CLR01 significantly reduces misfolded SOD1 in the spinal cord of G93A-SOD1 ALS mice but does not improve motor function in this fast-progressing model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1338489-62-5
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Molecular Weight 770.61
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Formula C42H30Na2O8P2
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SMILES
O=P(O)(O[Na])OC1=C2C([C@]3([H])C[C@@]2([H])C4=CC([C@]5([H])C6=CC=CC=C6[C@@]7([H])C5)=C7C=C43)=C(C8=C1[C@@]9([H])C%10=CC([C@@]%11([H])C%12=CC=CC=C%12[C@]%13([H])C%11)=C%13C=C%10[C@]8([H])C9)OP(O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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