CLR01 sodium 

CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1. CLR01 sodium reduces amyloid plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS)^[1].

CLR01 binds the N-terminal lysine of the KLVFF peptide with a K_d of 10 μM in PBS buffer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CLR01 (40 μg/kg; daily) reduces cortical plaque load and improves memory and mobility in triply transgenic Alzheimer's disease mice when administered at 40 μg/kg daily^[1].
CLR01 significantly reduces misfolded SOD1 in the spinal cord of G93A-SOD1 ALS mice but does not improve motor function in this fast-progressing model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

770.61

C₄₂H₃₀Na₂O₈P₂

1338489-62-5

O=P(O)(O[Na])OC1=C2C([C@]3([H])C[C@@]2([H])C4=CC([C@]5([H])C6=CC=CC=C6[C@@]7([H])C5)=C7C=C43)=C(C8=C1[C@@]9([H])C%10=CC([C@@]%11([H])C%12=CC=CC=C%12[C@]%13([H])C%11)=C%13C=C%10[C@]8([H])C9)OP(O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hadrovic I, et al. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019;7:657. Published 2019 Oct 1.  [Content Brief]