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Results for "

Endoplasmic reticulum (ER) stress

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (3) Aminotransferases (Transaminases) (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) Apoptosis (41) ATF6 (1) Autophagy (8) Bacterial (1) Bcl-2 Family (2) Calcium Channel (1) Caspase (13) CDK (1) Deubiquitinase (1) E1/E2/E3 Enzyme (2) Endogenous Metabolite (14) Environmental Pollutants (1) ERK (9) Eukaryotic Initiation Factor (eIF) (1) Exosomes (1) Fluorescent Dye (1) Fungal (1) HDAC (7) HIF/HIF Prolyl-Hydroxylase (1) HIV (5) HSP (3) IFNAR (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (6) JNK (4) Lipase (1) MDM-2/p53 (1) Mitochondrial Metabolism (6) MMP (1) mTOR (1) NF-κB (7) P-glycoprotein (1) p38 MAPK (4) Paraptosis (1) Parasite (1) PARP (1) PDI (2) PI3K (1) Reactive Oxygen Species (ROS) (5) Reference Standards (10) SARS-CoV (1) Sigma Receptor (1) VDAC (1) VEGFR (1) Virus Protease (4)
By Research Areas:	Cancer (49) Endocrinology (1) Infection (9) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (2)

By Targets:

Acyltransferase (1)

Akt (3)

Aminotransferases (Transaminases) (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (1)

Apoptosis (41)

ATF6 (1)

Autophagy (8)

Bacterial (1)

Bcl-2 Family (2)

Calcium Channel (1)

Caspase (13)

CDK (1)

Deubiquitinase (1)

E1/E2/E3 Enzyme (2)

Endogenous Metabolite (14)

Environmental Pollutants (1)

ERK (9)

Eukaryotic Initiation Factor (eIF) (1)

Exosomes (1)

Fluorescent Dye (1)

Fungal (1)

HDAC (7)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (5)

HSP (3)

IFNAR (1)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

JNK (4)

Lipase (1)

MDM-2/p53 (1)

Mitochondrial Metabolism (6)

MMP (1)

mTOR (1)

NF-κB (7)

P-glycoprotein (1)

p38 MAPK (4)

Paraptosis (1)

Parasite (1)

PARP (1)

PDI (2)

PI3K (1)

Reactive Oxygen Species (ROS) (5)

Reference Standards (10)

SARS-CoV (1)

Sigma Receptor (1)

VDAC (1)

VEGFR (1)

Virus Protease (4)

By Research Areas:

Cancer (49)

Endocrinology (1)

Infection (9)

Inflammation/Immunology (7)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: ER-phagy Endoplasmic Reticulum Oxidoreductase 1 (ERO1) PERK Mitogen- and Stress-Activated Protein Kinase (MSK)

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-A0281

4-Phenylbutyric acid Maximum Cited Publications 239 Publications Verification 4-PBA; Benzenebutyric acid	HDAC Virus Protease	Infection Cancer
4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum *(ER)* stress, used in cancer and infection research.

HY-13433

Thapsigargin 135+ Cited Publications	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an **endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase**. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-A0098

Tunicamycin Maximum Cited Publications 155 Publications Verification	Antibiotic Influenza Virus Fungal Bacterial Aminotransferases (Transaminases) Exosomes	Infection Inflammation/Immunology Cancer
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .

HY-19696

Tauroursodeoxycholate 100+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK .

HY-100487

TAK-243 80+ Cited Publications MLN7243	E1/E2/E3 Enzyme NF-κB Apoptosis	Cancer
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC₅₀=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis .

HY-15654

Sodium 4-phenylbutyrate Maximum Cited Publications 239 Publications Verification 4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium	HDAC Autophagy Apoptosis	Cancer
Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum *(ER)* stress, used in cancer and infection research .

HY-19696A

Tauroursodeoxycholate sodium 100+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0492

α-Lipoic Acid 10+ Cited Publications Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium 10+ Cited Publications Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0878

Bufotalin 4 Publications Verification	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation .

HY-124293

AA147 4 Publications Verification	ATF6 Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
AA147 is a **endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2** oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection .

HY-110188

BiP inducer X 5+ Cited Publications	Apoptosis	Neurological Disease
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress .

HY-100430

CCF642 1 Publications Verification	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-N16308

ER-Laurdan	Fluorescent Dye	Others
ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the **endoplasmic reticulum (ER)*. As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress*. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes .

HY-138364

YUM70 3 Publications Verification	HSP Apoptosis	Cancer
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC₅₀ of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model .

HY-19934

Pifusertib TAS-117	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy .

HY-116572A

TASIN-1	Reactive Oxygen Species (ROS) JNK Apoptosis Caspase	Cancer
TASIN-1 is a selective inhibitor of truncated *APC ^TR* (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering **endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis*, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC* mutant colorectal cancer .

HY-U00141

ABTL-0812 α-Hydroxylinoleic acid	Autophagy	Metabolic Disease Cancer
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity .

HY-19934A

Pifusertib hydrochloride TAS-117 hydrochloride	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy .

HY-N0492S

α-Lipoic Acid-d5 Thioctic acid-d₅; (±)-α-Lipoic acid-d₅; DL-α-Lipoic acid-d₅	Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .

HY-136528

RA-9	Deubiquitinase Apoptosis	Cancer
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .

HY-152153

GRP78-IN-3	HSP	Cancer
GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC₅₀ of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC₅₀ of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC₅₀ of 13.9 μM) .

HY-15654S

Phenylbutyrate-d11 sodium 4-PBA-d11 sodium; 4-Phenylbutyric acid-d11 sodium; Benzenebutyric acid-d11 sodium	Isotope-Labeled Compounds HDAC Autophagy Apoptosis	Cancer
Phenylbutyrate-d₁₁ (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research .

HY-148755

ERX-41	Lipase	Cancer
ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA). ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors .

HY-A0281S

4-Phenylbutyric acid-d11 4-PBA-d₁₁; Benzenebutyric acid-d₁₁	HDAC Virus Protease	Infection Cancer
4-Phenylbutyric acid-d₁₁ is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-153202

SLMP53-2	MDM-2/p53 Apoptosis	Cancer
SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity .

HY-19696S1

Tauroursodeoxycholate-d4 Tauroursodeoxycholic acid-d₄; TUDCA-d₄; UR 906-d₄	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696AS

Tauroursodeoxycholate-d4 sodium Tauroursodeoxycholic acid-d4 sodium; TUDCA-d4 sodium; UR 906-d4 sodium	Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696R

Tauroursodeoxycholate (Standard) Tauroursodeoxycholic acid (Standard); TUDCA (Standard); UR 906 (Standard)	Reference Standards ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696AR

Tauroursodeoxycholate sodium (Standard) Tauroursodeoxycholic acid sodium (Standard); TUDCA sodium (Standard); UR 906 sodium (Standard)	ERK Caspase Apoptosis Endogenous Metabolite Reference Standards	Cancer
Tauroursodeoxycholate (sodium) (Standard) is the analytical standard of Tauroursodeoxycholate (sodium). This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-121337

Flurochloridone R-40244	Environmental Pollutants Apoptosis Bcl-2 Family	Others
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces **endoplasmic reticulum (ER)** stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .

HY-176745

SW016789	VDAC	Metabolic Disease Endocrinology
SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca ²⁺ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction .

HY-135887

ZX-29	Anaplastic lymphoma kinase (ALK) Apoptosis Autophagy	Cancer
ZX-29 is a potent and selective ALK inhibitor with an IC₅₀ of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect .

HY-N0492R

α-Lipoic Acid (Standard) 10+ Cited Publications Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-A0281S3

4-Phenylbutyric acid-d4 4-PBA-d₄; Benzenebutyric acid-d₄	HDAC Virus Protease	Cancer
4-Phenylbutyric acid-d₂ is the deuterium labeled 4-Phenylbutyric acid . 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-147039

BOLD-100 free base NKP-1339 free base; IT-139 free base; KP-1339 free base	HSP Autophagy	Cancer
BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution .

HY-130133

DHW-221	PI3K mTOR Akt Apoptosis Paraptosis p38 MAPK Mitochondrial Metabolism P-glycoprotein CDK MMP HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
DHW-221 is a potent orally active dual PI3K/mTOR inhibitor, exhibiting low nanomolar potency against all four Class I PI3K isoforms and mTOR (PI3Kα, IC₅₀ = 0.50 nM; PI3Kβ, IC₅₀ = 1.9 nM; PI3Kγ, IC₅₀ = 1.8 nM; PI3Kδ, IC₅₀ = 0.74 nM; mTOR, IC₅₀ = 3.9 nM). DHW-221 exerts antitumor effects by blocking the PI3K/Akt/mTOR pathway and inducing mitochondrial apoptosis and paraptosis (via Endoplasmic Reticulum (ER) stress and MAPK signaling) and arrests cell cycle, thereby inhibiting cell migration, invasion and angiogenesis. DHW-221 inhibits tumor growth in both the A549/Taxol (HY-B0015) and the HCC827 xenograft mouse models. DHW-221 can be used for non-small cell lung cancer (NSCLC), colon and breast cancer research .

HY-N3642

Cristacarpin Erythrabyssin I; Erythrabissin I	Others	Cancer
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence .

HY-W011241

Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride	Apoptosis Parasite	Cancer
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .

HY-19696S

Tauroursodeoxycholate-d5 Tauroursodeoxycholic acid-d₅; TUDCA-d₅; UR 906-d₅	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-15654R

Sodium 4-phenylbutyrate (Standard) 4-PBA sodium (Standard); 4-Phenylbutyric acid sodium (Standard); Benzenebutyric acid sodium (Standard)	Reference Standards HDAC Autophagy Apoptosis	Cancer
Sodium 4-phenylbutyrate (Standard) is the analytical standard of Sodium 4-phenylbutyrate. This product is intended for research and analytical applications. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum *(ER)* stress, used in cancer and infection research .

HY-A0281S2

4-Phenylbutyric acid-d5 4-PBA-d₅; Benzenebutyric acid-d₅	HDAC Virus Protease	Cancer
4-Phenylbutyric acid-d₅ is the deuterium labeled 4-Phenylbutyric acid . 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research .

HY-121033

BS148	Sigma Receptor p38 MAPK Apoptosis	Cancer
BS148 is a selective sigma-2 receptor (S2R) agonist with a K_i 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP). BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma .

HY-116572

TASIN-1 hydrochloride	Reactive Oxygen Species (ROS) JNK Apoptosis Caspase	Cancer
TASIN-1 hydrochloride is a selective inhibitor of truncated *APC ^TR* (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 hydrochloride specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 hydrochloride exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering **endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis*, and inhibiting Akt survival signaling. TASIN-1 hydrochloride can be used to prevent and intervene in APC* mutant colorectal cancer .

HY-N0878R

Bufotalin (Standard)	Reference Standards Apoptosis Reactive Oxygen Species (ROS)	Cancer
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation .

HY-19696S2

Tauroursodeoxycholate-d4-1 Tauroursodeoxycholic acid-d₄-1; TUDCA-d₄-1; UR 906-d₄-1	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696BR

Tauroursodeoxycholate dihydrate (Standard) Tauroursodeoxycholic acid dihydrate (Standard); TUDCA dihydrate (Standard); UR 906 dihydrate (Standard)	ERK Caspase Apoptosis Endogenous Metabolite Reference Standards	Cancer
Tauroursodeoxycholate (dihydrate) (Standard) is the analytical standard of Tauroursodeoxycholate (dihydrate). This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK .

HY-121337R

Flurochloridone (Standard) R-40244 (Standard)	Reference Standards Apoptosis Bcl-2 Family	Others
Flurochloridone (Standard) is the analytical standard of Flurochloridone. This product is intended for research and analytical applications. Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .

HY-138844

3-AP-Me	Eukaryotic Initiation Factor (eIF) p38 MAPK JNK Apoptosis	Cancer
3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .

HY-N0492AR

α-Lipoic Acid sodium (Standard) Thioctic acid sodium (Standard); (±)-α-Lipoic acid sodium (Standard); DL-α-Lipoic acid sodium (Standard)	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

Cat. No.	상품명

HY-L054

Endoplasmic Reticulum Stress Compound Library

361 compounds

Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer.

MCE Endoplasmic Reticulum Stress Compound Library contains 361 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

Cat. No.	상품명	Target	Research Area

HY-P11298

d-T101 peptide	Caspase Apoptosis JNK p38 MAPK Interleukin Related IFNAR	Inflammation/Immunology Cancer
d-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site .

Cat. No.	상품명	Chemical Structure