1. Autophagy
  2. Autophagy
  3. ABTL-0812

ABTL-0812 (Synonyms: α-Hydroxylinoleic acid)

Cat. No.: HY-U00141 Purity: ≥98.0%
Handling Instructions

ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity.

For research use only. We do not sell to patients.

ABTL-0812 Chemical Structure

ABTL-0812 Chemical Structure

CAS No. : 57818-44-7

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5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
10 mg USD 635 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
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Description

ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity[1].

In Vitro

ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells[1].
Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human lung fibroblast MRC5 and squamous non-small cell lung (NSCLC) H157 cells
Concentration: 10, 30, 100 μM
Incubation Time: 48 hours
Result: Inhibited cell viability of squamous NSCLC H157 cells, not lung fibroblast cell line MRC-5.
In Vivo

ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts[1].
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female nude mice bearing MiaPaca2 and A549 xenograft models[1]
Dosage: 120 mg/kg
Administration: Administered by oral gavage; 5 times per week for 33 days
Result: Induced ER stress in human lung and pancreatic xenografts.
Clinical Trial
Molecular Weight

296.44

Formula

C₁₈H₃₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (843.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3734 mL 16.8668 mL 33.7336 mL
5 mM 0.6747 mL 3.3734 mL 6.7467 mL
10 mM 0.3373 mL 1.6867 mL 3.3734 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.06%

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Product Name:
ABTL-0812
Cat. No.:
HY-U00141
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