1. Autophagy
  2. Autophagy
  3. ABTL-0812

ABTL-0812 (Synonyms: α-Hydroxylinoleic acid)

Cat. No.: HY-U00141 Purity: 98.06%
Handling Instructions

ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity.

For research use only. We do not sell to patients.

ABTL-0812 Chemical Structure

ABTL-0812 Chemical Structure

CAS No. : 57818-44-7

Size Price Stock Quantity
5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
10 mg USD 635 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 Get quote
100 mg USD 2950 Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity[1].

In Vitro

ABTL-0812 (ABTL0812; 10-100 μM; 48 hours) inhibits cell viability of squamous NSCLC H157 cells[1].
Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment[1].

Cell Viability Assay[1]

Cell Line: Human lung fibroblast MRC5 and squamous non-small cell lung (NSCLC) H157 cells
Concentration: 10, 30, 100 μM
Incubation Time: 48 hours
Result: Inhibited cell viability of squamous NSCLC H157 cells, not lung fibroblast cell line MRC-5.
In Vivo

ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts[1].
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively[1].

Animal Model: Athymic female nude mice bearing MiaPaca2 and A549 xenograft models[1]
Dosage: 120 mg/kg
Administration: Administered by oral gavage; 5 times per week for 33 days
Result: Induced ER stress in human lung and pancreatic xenografts.
Clinical Trial
Molecular Weight

296.44

Formula

C₁₈H₃₂O₃

CAS No.

57818-44-7

SMILES

CCCCC/C=C\C/C=C\CCCCCCC(O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (16.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3734 mL 16.8668 mL 33.7336 mL
5 mM 0.6747 mL 3.3734 mL 6.7467 mL
10 mM 0.3373 mL 1.6867 mL 3.3734 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ABTL-0812α-Hydroxylinoleic acidABTL0812ABTL 0812AutophagyInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ABTL-0812
Cat. No.:
HY-U00141
Quantity:
MCE Japan Authorized Agent: