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Cat. No.: HY-N3642

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Cristacarpin

(Synonyms: Erythrabyssin I; Erythrabissin I)

Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence.

For research use only. We do not sell to patients.

CAS No.: 74515-47-2
Formula: C₂₁H₂₂O₅
Molecular Weight:354.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Cristacarpin Chemical Structure

CAS No.: 74515-47-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	3.36 μM Compound: 8	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28189086]
CHO	IC₅₀	>20 μM Compound: 2	Cytotoxicity against CHO cells Cytotoxicity against CHO cells	[PMID: 8277323]
CHO	IC₅₀	4 μM Compound: 2	Cytotoxicity against p-glycoprotein overexpressing CHO cells Cytotoxicity against p-glycoprotein overexpressing CHO cells	[PMID: 8277323]
P388	IC₅₀	>10 μM Compound: 2	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 8277323]

Chemical Information

CAS No. 74515-47-2
Molecular Weight 354.40
Formula C₂₁H₂₂O₅
SMILES

O[C@]12[C@](OC3=C(C/C=C(C)\C)C(OC)=CC=C32)([H])C4=CC=C(O)C=C4OC1
Synonyms

Erythrabyssin I; Erythrabissin I
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chakraborty S, et al. Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21(waf-1). Age (Dordr). 2016 Jun;38(3):62. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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