4-Phenylbutyric acid-d11
Based on 1 Customer Validation
4-Phenylbutyric acid-d11 is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 358730-86-6
- Formula: C10HD11O2
- Molecular Weight:175.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 358730-86-6
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Unlabeled Cas 1821-12-1
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Appearance Solid
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Molecular Weight 175.27
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Formula C10HD11O2
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Color White to off-white
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SMILES
OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O
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Synonyms
4-PBA-d11; Benzenebutyric acid-d11
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (570.55 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12 [Content Brief]
[3]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [Content Brief]
[4]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.7055 mL | 28.5274 mL | 57.0548 mL | 142.6371 mL |
| 5 mM | 1.1411 mL | 5.7055 mL | 11.4110 mL | 28.5274 mL | |
| 10 mM | 0.5705 mL | 2.8527 mL | 5.7055 mL | 14.2637 mL | |
| 15 mM | 0.3804 mL | 1.9018 mL | 3.8037 mL | 9.5091 mL | |
| 20 mM | 0.2853 mL | 1.4264 mL | 2.8527 mL | 7.1319 mL | |
| 25 mM | 0.2282 mL | 1.1411 mL | 2.2822 mL | 5.7055 mL | |
| 30 mM | 0.1902 mL | 0.9509 mL | 1.9018 mL | 4.7546 mL | |
| 40 mM | 0.1426 mL | 0.7132 mL | 1.4264 mL | 3.5659 mL | |
| 50 mM | 0.1141 mL | 0.5705 mL | 1.1411 mL | 2.8527 mL | |
| 60 mM | 0.0951 mL | 0.4755 mL | 0.9509 mL | 2.3773 mL | |
| 80 mM | 0.0713 mL | 0.3566 mL | 0.7132 mL | 1.7830 mL | |
| 100 mM | 0.0571 mL | 0.2853 mL | 0.5705 mL | 1.4264 mL |
4-Phenylbutyric acid-d11 Related Classifications
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