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Cat. No.: HY-183140

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DH20931

DH20931 is a ceramide synthase 2 (CerS2) activator. DH20931 inhibits growth of cancer cells by inducing lipotoxic endoplasmic reticulum (ER) stress. DH20931 shows synergistic anti-tumor efficacy with Doxorubicin (HY-15142A). DH20931 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1629992-28-4
Formula: C₂₁H₂₁ClN₂O₂
Molecular Weight:368.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

DH20931 Chemical Structure

CAS No.: 1629992-28-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

Caspase 3

All Acyltransferase Isoforms :

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	0.3 μM Compound: 1c, DH20931	Cytotoxicity against human BT474 cells assessed as growth inhibition after 48 hrs by methylene blue staining-based assay Cytotoxicity against human BT474 cells assessed as growth inhibition after 48 hrs by methylene blue staining-based assay	[PMID: 25240616]

In Vitro

DH20931 potently inhibits the growth of MDA-MB231, MDA-MB468, BT474, MCF7, and T47D cancer cells with IC₅₀ values of 3.9, 1.8, 0.3, 1.3 and 1.0 μM^[1].
DH20931 significantly reduces the required IC₅₀ of Doxorubicin (HY-15142A) by 3-8-fold, resulting in hyper-activation of the UPR, maximized ATF4/CHOP/PUMA expression, and a marked increase in cleaved caspase-3^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1629992-28-4
Molecular Weight 368.86
Formula C₂₁H₂₁ClN₂O₂
SMILES

COC1=CC=C2C3=C4C5=C(CCN4C=[N+]3CCC2=C1)C=C(C=C5)OC.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jaiswal AS, et al. Anti-tumor activity of novel biisoquinoline derivatives against breast cancers. Bioorg Med Chem Lett. 2014;24(20):4850-4853. [Content Brief]

[2]. Alatawi H, et al. A novel CerS2 activator, DH20931, synergizes with doxorubicin to overcome therapeutic resistance in breast cancer[J]. Cancer Research, 2026, 86(7_Supplement): 4457-4457.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DH20931

All Acyltransferase Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DH20931 Related Classifications

HY-183140 Related Classifications