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Results for "

N-desmethyl

" in MedChemExpress (MCE) Product Catalog:

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119

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-70002A

N-Desmethyl enzalutamide 1 Publications Verification N-desmethyl MDV 3100	Androgen Receptor	Cancer
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-G0017

N-Desmethyl imatinib 1 Publications Verification Norimatinib; Imatinib metabolite N-desmethyl imatinib; CGP 74588	Drug Metabolite P-glycoprotein Apoptosis	Neurological Disease Cancer
N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .

HY-N7612

N-Desmethyl Galanthamine Norgalanthamine	Cholinesterase (ChE) Drug Metabolite	Neurological Disease
N-Desmethyl Galanthamine (N-Norgalanthamine) is a metabolite of Galanthamine (HY-76299). N-Desmethyl Galanthamine is an EeAChE inhibitor with an IC₅₀ of 2.76 μM. N-Desmethyl Galanthamine can be used in the research of Alzheimer's disease .

HY-12388A

N-Desmethyl clomipramine hydrochloride desmethylclomipramine hydrochloride; Norclomipramine hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-135331

N-Desmethyl-Apalutamide 1 Publications Verification	Androgen Receptor Cytochrome P450	Cancer
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-117605

N-Desmethyl Sildenafil desmethylsildenafil; UK-103,320	Phosphodiesterase (PDE)	Cardiovascular Disease
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-W740010

N-Desmethyl rosuvastatin disodium hydrate	Drug Metabolite HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Metabolic Disease Cancer
N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504). N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism .

HY-G0017S

N-Desmethyl imatinib-d8 Norimatinib-d₈; Imatinib metabolite N-desmethyl imatinib-d₈; CGP 74588-d₈	Isotope-Labeled Compounds Drug Metabolite P-glycoprotein Apoptosis	Neurological Disease Cancer
N-Desmethyl imatinib-d₈ is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib (HY-G0017). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .

HY-171459

LEQ803 N-desmethyl Ribociclib	Drug Metabolite Cytochrome P450	Cancer
LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology .

HY-70002AS

N-Desmethyl enzalutamide-d6 N-desmethyl MDV 3100-d₆	Androgen Receptor	Cancer
N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-160849

N-Desmethyl Rilmazolam	GABA Receptor	Others Metabolic Disease
N-desmethyl Rilmazolam, a triazolobenzodiazepine, serves as an analytical reference standard. N-desmethyl Rilmazolam is an active metabolite derived from rilmazafone (HY-106547). N-desmethyl Rilmazolam is designed for use in research and forensic settings .

HY-143922S

N-Desmethyl Bedaquiline-d6	Isotope-Labeled Compounds	Others
N-Desmethyl Bedaquiline-d₆ is the deuterium labeled N-Desmethyl Bedaquiline .

HY-Z8033

N-Desmethyl diltiazem hydrochloride	Cytochrome P450	Metabolic Disease
N-Desmethyl diltiazem hydrochloride is a substrate for CYP3A7 metabolism, which is the predominant fetal form and is minimally expressed in adults .

HY-135392

N-Desmethyl Pimavanserin AC-279	Drug Metabolite	Neurological Disease
N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC₅₀ and pK_d of 8.73 and 9.3, respectively.

HY-G0010

*Netupitant metabolite N-desmethyl* Netupitant** N-desmethyl Netupitant	Drug Metabolite	Neurological Disease Metabolic Disease
N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.

HY-W754151

N-Desmethyl apalutamide-d4	Isotope-Labeled Compounds	Others
N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-117605R

N-Desmethyl Sildenafil (Standard) desmethylsildenafil (Standard); UK-103,320 (Standard)	Reference Standards Phosphodiesterase (PDE)	Cardiovascular Disease
N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-128038

N-Desmethyl-loperamide	Opioid Receptor	Neurological Disease
N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral μopioid receptors with a K_i value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein .

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride desmethylclomipramine-d3 hydrochloride; Norclomipramine-d3 hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine

HY-132626S

N-Desmethyl Tamoxifen-d5	Isotope-Labeled Compounds	Others
N-Desmethyl Tamoxifen-d₅ is the deuterium labeled N-Desmethyl Tamoxifen .

HY-139519S

N-Desmethyl diphenhydramine-d3 hydrochloride	Histamine Receptor	Inflammation/Immunology
N-Desmethyl diphenhydramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride .

HY-W662579

N-Desmethyl clotiazepam desmethylclotiazepam	Drug Metabolite	Metabolic Disease
N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam .

HY-131527R

Wy-45494 hydrochloride (Standard) N-desmethyl Venlafaxine hydrochloride (Standard); Wy 45494 (Standard)	Serotonin Transporter Reference Standards	Metabolic Disease
Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

HY-117605S

N-Desmethyl Sildenafil-d8 desmethylsildenafil-d₈; UK-103,320-d₈	Phosphodiesterase (PDE) Isotope-Labeled Compounds	Neurological Disease Cancer
N-Desmethyl Sildenafil-d₈ is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-70002AR

N-Desmethyl enzalutamide (Standard) N-desmethyl MDV 3100 (Standard)	Androgen Receptor Reference Standards	Cancer
N-desmethyl Enzalutamide (Standard) is the analytical standard of N-desmethyl Enzalutamide. This product is intended for research and analytical applications. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-W013775R

N-Desmethyl ofloxacin (Standard)	Biochemical Assay Reagents Reference Standards	Others
N-Desmethyl ofloxacin (Standard) is the analytical standard of N-Desmethyl ofloxacin. This product is intended for research and analytical applications. N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-137200

N-Desmethyl Bendamustine	Drug Metabolite	Cancer
N-Desmethyl Bendamustine is a metabolite of Bendamustine (HY-13567). N-Desmethyl Bendamustine has cytotoxic effect in several lymphoma cell lines and peripheral blood lymphocytes .

HY-142283BS

N-Desmethyl dosimertinib-d5	EGFR	Cancer
N-Desmethyl dosimertinib-d₅ is the deuterium labeled N-Desmethyl dosimertinib.

HY-141750S1

N-Desmethyl Zolmitriptan-d3	Isotope-Labeled Compounds	Others
N-Desmethyl Zolmitriptan-d₃ is the deuterium labeled N-Desmethyl Zolmitriptan .

HY-132685S

N-Desmethyl Topotecan-d3	Isotope-Labeled Compounds	Others
N-Desmethyl Topotecan-d₃ is the deuterium labeled N-Desmethyl Topotecan .

HY-132685AS

N-Desmethyl topotecan-d3 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Topotecan-d3 hydrochloride is the deuterium labeled N-Desmethyl Topotecan hydrochloride .

HY-132344S

N-Desmethyl asenapine-d4 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl asenapine-d₄ (hydrochloride) is the deuterium labeled N-Desmethyl asenapine hydrochloride .

HY-144143S

N-Desmethyl Olopatadine-d3 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Olopatadine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Olopatadine hydrochloride .

HY-132653S

N-Desmethyl Droloxifene-d5	Isotope-Labeled Compounds	Others
N-Desmethyl Droloxifene-d₅ is the deuterium labeled N-Desmethyl Droloxifene .

HY-G0010S

N-desmethyl Netupitant-d6	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease Endocrinology
N-desmethyl Netupitant-d₆ is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.

HY-W741222S

N-Desmethyl Olopatadine-d6	Isotope-Labeled Compounds	Others
N-Desmethyl Olopatadine-d₆ is deuterium-labeled N-Desmethyl Olopatadine (HY-W741222) .

HY-108226

*Regorafenib N-oxide and N-desmethyl* (M5)** N-desmethyl regorafenib N-oxide	Drug Metabolite Raf VEGFR c-Kit	Cancer
Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-G0017A

N-Desmethyl imatinib mesylate Norimatinib mesylate; Imatinib metabolite N-desmethyl imatinib mesylate; CGP 74588 mesylate	Drug Metabolite P-glycoprotein Apoptosis	Neurological Disease Cancer
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib mesylate binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib mesylate induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib mesylate exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib mesylate can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .

HY-143767S

N-Desmethyl Azelastine-d4-1	Isotope-Labeled Compounds	Others
N-Desmethyl Azelastine-d₄-1 is the deuterium labeled N-Desmethyl Azelastine .

HY-Z3203S

N-Desmethyl rosuvastatin-d6 disodium	Isotope-Labeled Compounds	Others
N-Desmethyl Rosuvastatin-d₆ (disodium) is the deuterium labeled N-Desmethyl Rosuvastatin disodium .

HY-143931S

N-Desmethyl citalopram-d4 oxalate	Isotope-Labeled Compounds	Others
N-Desmethyl citalopram-d₄ (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate .

HY-172297

*Pyrazole N-Desmethyl* sildenafil**	Phosphodiesterase (PDE) Parasite	Infection Cardiovascular Disease Cancer
Pyrazole N-Desmethyl sildenafil (Compound 10) is an analog of Sildenafil (HY-15025). Pyrazole N-Desmethyl sildenafil shows 16% inhibition on Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) with 100 µM .

HY-12388AR

N-Desmethyl clomipramine hydrochloride (Standard) desmethylclomipramine hydrochloride (Standard); Norclomipramine hydrochloride (Standard)	Reference Standards Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-G0017R

N-Desmethyl imatinib (Standard) Norimatinib (Standard); Imatinib metabolite N-desmethyl imatinib (Standard); CGP 74588 (Standard)	Reference Standards Drug Metabolite P-glycoprotein Apoptosis	Others
N‑Desmethyl imatinib (Standard) is the analytical standard of N‑Desmethyl imatinib (Norimatinib) (HY-G0017R). This product is intended for research and analytical applications. N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .

HY-W013775

N-Desmethyl ofloxacin	Biochemical Assay Reagents	Others
N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W709612

*Regorafenib N-oxide and N-desmethyl* (M5)-d3-1** N-desmethyl regorafenib N-oxide-d₃-1	Isotope-Labeled Compounds VEGFR Raf c-Kit Drug Metabolite	Cancer
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-W587540

*Descladinose 6-N-desmethyl* azithromycin**	Drug Intermediate	Others
Descladinose 6-N-Desmethyl Azithromycin is a teramycin impurity.

HY-W295339S

N-Desmethyl venlafaxine-d3	Isotope-Labeled Compounds	Others
N-Desmethyl venlafaxine-d₃ is a deuterium labeled compound.

HY-108226S

*Regorafenib N-oxide and N-desmethyl* (M5)-d3** N-desmethyl regorafenib N-oxide-d₃	Isotope-Labeled Compounds	Others
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-100647S

N-Desmethyl Nefopam-d4 hydrochloride	Isotope-Labeled Compounds	Others
N-Desmethyl Nefopam-d₄ (hydrochloride) is deuterium labeled N-Desmethylnefopam (hydrochloride).

Cat. No.	Product Name	Type

HY-W013775R

N-Desmethyl ofloxacin (Standard)	Biochemical Assay Reagents
N-Desmethyl ofloxacin (Standard) is the analytical standard of N-Desmethyl ofloxacin. This product is intended for research and analytical applications. N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W013775

N-Desmethyl ofloxacin	Biochemical Assay Reagents
N-Desmethyl ofloxacin is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

Cat. No.	Product Name	Target	Research Area

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-N7612

N-Desmethyl Galanthamine Norgalanthamine	Alkaloids other families Classification of Application Fields Other Alkaloids Other Diseases Plants Disease Research Fields Source Classification	Cholinesterase (ChE) Drug Metabolite
N-Desmethyl Galanthamine (N-Norgalanthamine) is a metabolite of Galanthamine (HY-76299). N-Desmethyl Galanthamine is an EeAChE inhibitor with an IC₅₀ of 2.76 μM. N-Desmethyl Galanthamine can be used in the research of Alzheimer's disease .

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-12388

N-Desmethyl clomipramine desmethylclomipramine; Norclomipramine	Natural Products Endogenous metabolite Source Classification	Drug Metabolite
Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .

HY-N0913R

Manninotriose (Standard)	Structural Classification Polysaccharides Microorganisms other families Plants Saccharides Source Classification	Reference Standards Antifolate Thymidylate Synthase
Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Chemical Structure

HY-G0017S

N-Desmethyl imatinib-d8

N-Desmethyl imatinib-d₈ is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib (HY-G0017). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .

HY-70002AS

N-Desmethyl enzalutamide-d6

N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-143922S

N-Desmethyl Bedaquiline-d6
N-Desmethyl Bedaquiline-d₆ is the deuterium labeled N-Desmethyl Bedaquiline .

HY-W754151

N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-132626S

N-Desmethyl Tamoxifen-d5
N-Desmethyl Tamoxifen-d₅ is the deuterium labeled N-Desmethyl Tamoxifen .

HY-139519S

N-Desmethyl diphenhydramine-d3 hydrochloride
N-Desmethyl diphenhydramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl diphenhydramine hydrochloride .

HY-117605S

N-Desmethyl Sildenafil-d8
N-Desmethyl Sildenafil-d₈ is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-W753602

*Acetamiprid-N-desmethyl-13C,d3*
Acetamiprid-N-desmethyl- ¹³C,d3 is the ¹³C and deuterium labeled isotope of Acetamiprid-N-desmethyl( ¹³C,d3)(HY-B0823).Acetamiprid is a nAChR agonist that has been implicated in neuromuscular and reproductive disorders.

HY-142283BS

N-Desmethyl dosimertinib-d5
N-Desmethyl dosimertinib-d₅ is the deuterium labeled N-Desmethyl dosimertinib.

HY-141750S1

N-Desmethyl Zolmitriptan-d3
N-Desmethyl Zolmitriptan-d₃ is the deuterium labeled N-Desmethyl Zolmitriptan .

HY-132685S

N-Desmethyl Topotecan-d3
N-Desmethyl Topotecan-d₃ is the deuterium labeled N-Desmethyl Topotecan .

HY-132685AS

N-Desmethyl topotecan-d3 hydrochloride
N-Desmethyl Topotecan-d3 hydrochloride is the deuterium labeled N-Desmethyl Topotecan hydrochloride .

HY-132344S

N-Desmethyl asenapine-d4 hydrochloride
N-Desmethyl asenapine-d₄ (hydrochloride) is the deuterium labeled N-Desmethyl asenapine hydrochloride .

HY-144143S

N-Desmethyl Olopatadine-d3 hydrochloride
N-Desmethyl Olopatadine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Olopatadine hydrochloride .

HY-132653S

N-Desmethyl Droloxifene-d5
N-Desmethyl Droloxifene-d₅ is the deuterium labeled N-Desmethyl Droloxifene .

HY-G0010S

N-desmethyl Netupitant-d6
N-desmethyl Netupitant-d₆ is the deuterium labeled N-desmethyl Netupitant, which is a metabolite of Netupitant.

HY-W741222S

N-Desmethyl Olopatadine-d6
N-Desmethyl Olopatadine-d₆ is deuterium-labeled N-Desmethyl Olopatadine (HY-W741222) .

HY-143767S

N-Desmethyl Azelastine-d4-1
N-Desmethyl Azelastine-d₄-1 is the deuterium labeled N-Desmethyl Azelastine .

HY-Z3203S

N-Desmethyl rosuvastatin-d6 disodium
N-Desmethyl Rosuvastatin-d₆ (disodium) is the deuterium labeled N-Desmethyl Rosuvastatin disodium .

HY-143931S

N-Desmethyl citalopram-d4 oxalate
N-Desmethyl citalopram-d₄ (oxalate) is the deuterium labeled N-Desmethyl citalopram oxalate .

HY-W709612

*Regorafenib N-oxide and N-desmethyl* (M5)-d3-1**
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-W295339S

N-Desmethyl venlafaxine-d3
N-Desmethyl venlafaxine-d₃ is a deuterium labeled compound.

HY-108226S

*Regorafenib N-oxide and N-desmethyl* (M5)-d3**
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-100647S

N-Desmethyl Nefopam-d4 hydrochloride
N-Desmethyl Nefopam-d₄ (hydrochloride) is deuterium labeled N-Desmethylnefopam (hydrochloride).

HY-120422S

N-Desmethyl Regorafenib-d3
N-Desmethyl Regorafenib-d₃ is deuterium labeled BAY-751098.

HY-150544S

N-Desmethyl selegiline-d5 hydrochloride
N-Desmethyl Selegiline-dd₅ hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride . N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118788S

N-Desmethyl rosiglitazone-d4
N-Desmethyl rosiglitazone-d₄ is the deuterium labeled N-Desmethyl rosiglitazone .

HY-G0017S1

N-Desmethyl imatinib-d4

N-Desmethyl imatinib-d₄ is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .

HY-U00199S

N-Desmethyl zopiclone-d8
N-Desmethyl zopiclone-d₈ is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-135392S

N-Desmethyl Pimavanserin-d9 hydrochloride
N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC₅₀ and pK_d of 8.73 and 9.3, respectively .

HY-143810S

N-Desmethyl Mifepristone-d3
N-Desmethyl Mifepristone-d₃ is the deuterium labeled N-Desmethyl Mifepristone . N-Desmethyl Mifepristone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108226S1

*Regorafenib N-oxide and N-desmethyl* (M5)-13C6**
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5) .

HY-W740183

N-Desmethyl prochlorperazine dimaleate-d8
N-Desmethyl prochlorperazine dimaleate-d₈ is the deuterium labeled 2-Chloro-10-(3-(piperazin-1-yl)propyl)-10H-phenothiazine (HY-W722908).

HY-12388S

N-Desmethyl clomipramine-d7
N-Desmethyl clomipramine-d₇ (Desmethylclomipramine-d₇) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .

HY-12388S1

N-Desmethyl clomipramine-d6
N-Desmethyl clomipramine-d₆ (Desmethylclomipramine-d₆) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .

HY-158192S

N-Desmethyl diltiazem-d4
N-Desmethyl diltiazem-d₄ is deuterium labeled N-Desmethyl diltiazem .

HY-W740049

*(R,S)-N-Desmethyl* rosuvastatin-d6 disodium**
N-Desmethyl rosuvastatin-d₆ disodium salt is the deuterium labeled N-Desmethyl rosuvastatin disodium salt.

HY-135331S

N-Desmethyl-Apalutamide-15N,d4

N-Desmethyl-Apalutamide-15N,d4 is the ¹⁵N and deuterium labeled isotope of N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-131332S1

N-Desmethyl ulipristal acetate-d3
N-Desmethyl ulipristal-d₃ ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl-d₃) acetate is deuterium labeled N-Desmethyl ulipristal acetate ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl) .

HY-144386S

N-Desmethyl L-ergothioneine methyl ester-d6
N-Desmethyl L-ergothioneine methyl ester-d₆ is the deuterium labeled N-Desmethyl L-ergothioneine methyl ester .

HY-132647S

N-Desmethyl-4’-hydroxy Tamoxifen-d3 (E/Z Mixture)
N-Desmethyl-4’-hydroxy Tamoxifen-d₃ (E/Z Mixture) is the deuterium labeled N-Desmethyl-4’-hydroxy Tamoxifen (E/Z Mixture) .

HY-118601S

N-Desmethyl Pirenzepine-d8
N-Desmethyl Pirenzepine-d₈ is the deuterium labeled N-Desmethyl Pirenzepine .

HY-W741626

N-Desmethyl selegiline-d5
N-Desmethyl selegiline-d₅ is the deuterium labeled N-Desmethyl selegiline . It contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132709S

N-Desmethyl-diltiazem-d4 hydrochloride
N-Desmethyl-diltiazem-d₄ (hydrochloride) is the deuterium labeled N-Desmethyl-diltiazem hydrochloride .

HY-144144S

*(E)-N-Desmethyl* Olopatadine-d3 hydrochloride**
(E)-N-Desmethyl Olopatadine-d₃ (hydrochloride) is the deuterium labeled (E)-N-Desmethyl Olopatadine.

HY-157207S

N-Desmethyl-Atomoxetine labeled-d5 hydrochloride
N-Desmethyl-Atomoxetine labeled-d5 hydrochloride is the deuterium labeled N-Desmethyl-Atomoxetine labeled hydrochloride .

HY-143949S

*(Rac)-N-desmethyl* Dapoxetine-d7 hydrochloride**
(Rac)-N-desmethyl Dapoxetine-d₇ hydrochloride is the deuterium labeled (Rac)-N-desmethyl Dapoxetine hydrochloride .

HY-143834S

*O-Desacetyl-N-desmethyl* Diltiazem-d3**
O-Desacetyl-N-desmethyl Diltiazem-d₃ is the deuterium labeled O-Desacetyl-N-desmethyl Diltiazem .

Cat. No.	Product Name		Classification

HY-150544S

N-Desmethyl selegiline-d5 hydrochloride (-)-N-desmethylselegiline-d5 hydrochloride		Alkynes
N-Desmethyl Selegiline-dd₅ hydrochloride is the deuterium labeled N-Desmethyl Selegiline hydrochloride . N-Desmethyl Selegiline-d5 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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