Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
124 Results for "
N-desmethyl
" in MedChemExpress (MCE) Product Catalog:
Products (124)
124 Results for "N-desmethyl" in MCE Product Catalog:
1
Target:
Research Areas:
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .
1
1 Cited Publications
Cat. No.: HY-G0017
CAS No.: 404844-02-6
Synonyms: Norimatinib; Imatinib metabolite N-desmethyl imatinib; CGP 74588
Research Areas:
N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia .
1
Target:
1
1 Cited Publications
Research Areas:
N-Desmethyl-Apalutamide, the major active metabolite of Apalutamide (HY-16060), is a selective competitive inhibitor of androgen receptor. N-Desmethyl-Apalutamide is catalyzed by CYP3A4 and CYP2C8 enzymes. The plasma protein binding rate of N-Desmethyl-Apalutamide reaches 95%, with albumin as the primary binding protein. N-Desmethyl-Apalutamide is suitable for prostate cancer-related research .
1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P1108A
Target:
Research Areas:
1
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
Target:
Synonyms: desmethylclomipramine hydrochloride; Norclomipramine hydrochloride
Target:
Research Areas:
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
Synonyms: desmethylsildenafil; UK-103,320
Target:
Research Areas:
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .
Cat. No.: HY-W740010
Research Areas:
N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504). N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism .
Cat. No.: HY-G0017S
CAS No.: 1185103-28-9
Synonyms: Norimatinib-d8; Imatinib metabolite N-desmethyl imatinib-d8; CGP 74588-d8
Cat. No.: HY-171459
CAS No.: 1211441-59-6
Synonyms: N-desmethyl Ribociclib
Target:
Research Areas:
LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology .
Cat. No.: HY-70002AS
CAS No.: 2748567-63-5
Synonyms: N-desmethyl MDV 3100-d6
Cat. No.: HY-160849
CAS No.: 50330-93-3
Target:
Research Areas:
N-Desmethyl Rilmazolam is a metabolite of Rilmazolam (HY-150334) and 450191-S (HY-U00228). N-Desmethyl Rilmazolam significantly enhances the activity of 7-ethoxycoumarin O-deethylase. N-Desmethyl Rilmazolam can be used in insomnia-related studies .
Cat. No.: HY-Z8033
CAS No.: 130606-60-9
Target:
Research Areas:
N-Desmethyl diltiazem hydrochloride is a substrate for CYP3A7 metabolism, which is the predominant fetal form and is minimally expressed in adults .
Synonyms: AC-279
Target:
Research Areas:
N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
Cat. No.: HY-G0010
CAS No.: 290296-72-9
Synonyms: N-desmethyl Netupitant
Target:
Research Areas:
N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.
Cat. No.: HY-W754151
Cat. No.: HY-117605R
CAS No.: 139755-82-1
Synonyms: desmethylsildenafil (Standard); UK-103,320 (Standard)
Research Areas:
N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
