N-Desmethyl xanomeline
N-Desmethyl xanomeline is a pharmacologically active metabolite of Xanomeline (HY-105182). N-Desmethyl xanomeline binds to muscarinic, serotonergic, histaminergic and dopaminergic receptors. N-Desmethyl xanomeline can be used for the research of schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 131986-96-4
- Formula: C13H21N3OS
- Molecular Weight:267.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
N-Desmethyl xanomeline (0.1 nM-10 µM) exhibits a complex polypharmacological profile with potent binding to σ1, 5-HT2B, 5-HT1D, 5-HT7, and muscarinic receptors (Ki values range from 6.2 nM to 219 nM)[1].
N-Desmethyl xanomeline (10 µM) exhibits potential agonism at multiple muscarinic, serotonergic, and histaminergic GPCRs[1].
N-Desmethyl xanomeline acts as a full or partial agonist at 5-HT1D (potencies 17-130 nM) and 5-HT1A (EC50 = 2.20 µM) receptors, and weak partial agonist at 5-HT2A, 5-HT2C, H3, and H4 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 131986-96-4
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Molecular Weight 267.39
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Formula C13H21N3OS
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SMILES
CCCCCCOC1=NSN=C1C2=CCCNC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Desmethyl xanomeline Related Classifications
HY-181425 Related Classifications
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