N-Desmethyl xanomeline 

N-Desmethyl xanomeline is a pharmacologically active metabolite of Xanomeline (HY-105182). N-Desmethyl xanomeline binds to muscarinic, serotonergic, histaminergic and dopaminergic receptors. N-Desmethyl xanomeline can be used for the research of schizophrenia^[1].

N-Desmethyl xanomeline (0.1 nM-10 µM) exhibits a complex polypharmacological profile with potent binding to σ1, 5-HT_2B, 5-HT_1D, 5-HT₇, and muscarinic receptors (Ki values range from 6.2 nM to 219 nM)^[1].
N-Desmethyl xanomeline (10 µM) exhibits potential agonism at multiple muscarinic, serotonergic, and histaminergic GPCRs^[1].
N-Desmethyl xanomeline acts as a full or partial agonist at 5-HT_1D (potencies 17-130 nM) and 5-HT_1A (EC₅₀ = 2.20 µM) receptors, and weak partial agonist at 5-HT_2A, 5-HT_2C, H₃, and H₄ receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

267.39

C₁₃H₂₁N₃OS

131986-96-4

CCCCCCOC1=NSN=C1C2=CCCNC2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kensuke Sakamoto, et al. The polypharmacological profiles of xanomeline and N-desmethylxanomeline. bioRxiv. November 21, 2025.