2. Metabolic Enzyme/Protease
  3. Drug Metabolite Cytochrome P450
  4. N-Desmethyl Rilmazolam

N-Desmethyl Rilmazolam is a metabolite of Rilmazolam (HY-150334) and 450191-S (HY-U00228). N-Desmethyl Rilmazolam significantly enhances the activity of 7-ethoxycoumarin O-deethylase. N-Desmethyl Rilmazolam can be used in insomnia-related studies.

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N-Desmethyl Rilmazolam

N-Desmethyl Rilmazolam Chemical Structure

CAS No. : 50330-93-3

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N-Desmethyl Rilmazolam Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

N-Desmethyl Rilmazolam is a metabolite of Rilmazolam (HY-150334) and 450191-S (HY-U00228). N-Desmethyl Rilmazolam significantly enhances the activity of 7-ethoxycoumarin O-deethylase. N-Desmethyl Rilmazolam can be used in insomnia-related studies[1][2].

In Vivo

Administration of N-Desmethyl Rilmazolam (Compound M-2) (50 mg/kg; i.p.; once daily; 3 days) significantly increases hepatic 7-alkoxycoumarin O-dealkylase activities in mice, with the highest induction seen for 7-ethoxycoumarin O-deethylase activity (1.23 nmol/min/mg protein)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Shionogi DS strain (male, 8 weeks old)[1]
Dosage: 50 mg/kg
Administration: i.p.; once daily; 3 days
Result: Increased hepatic 7-methoxycoumarin O-demethylase activity to 0.91 nmol/min/mg protein.
Increased hepatic 7-ethoxycoumarin O-deethylase activity to 1.23 nmol/min/mg protein.
Increased hepatic 7-propoxycoumarin O-depropylase activity to 0.41 nmol/min/mg protein.
Showed statistically significant differences (p < 0.01) compared to the control group.
Molecular Weight

386.23

Formula

C18H13Cl2N5O
CAS No.
SMILES

O=C(C1=NN(C2=C(C(C3=C(Cl)C=CC=C3)=NC4)C=C(Cl)C=C2)C4=N1)NC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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N-Desmethyl Rilmazolam Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Desmethyl Rilmazolam50330-93-3Drug MetaboliteCytochrome P450CYPs7-ethoxycoumarin O-deethylasecytochrome P-450-dependent 7-alkoxycoumarin O-dealkylaseHPLCratsmiceinsomniahepatic drug-metabolizing enzymeInhibitorinhibitorinhibit

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