Wy-45494 hydrochloride
Based on 1 Customer Validation
Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 93413-90-2
- Formula: C16H26ClNO2
- Molecular Weight:299.84
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 93413-90-2
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Appearance Solid
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Molecular Weight 299.84
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Formula C16H26ClNO2
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Color White to off-white
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SMILES
OC1(C(C2=CC=C(OC)C=C2)CNC)CCCCC1.[H]Cl
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Synonyms
N-Desmethyl Venlafaxine hydrochloride; Wy 45494
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 116.67 mg/mL (389.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3351 mL | 16.6756 mL | 33.3511 mL | 83.3778 mL |
| 5 mM | 0.6670 mL | 3.3351 mL | 6.6702 mL | 16.6756 mL | |
| 10 mM | 0.3335 mL | 1.6676 mL | 3.3351 mL | 8.3378 mL | |
| 15 mM | 0.2223 mL | 1.1117 mL | 2.2234 mL | 5.5585 mL | |
| 20 mM | 0.1668 mL | 0.8338 mL | 1.6676 mL | 4.1689 mL | |
| 25 mM | 0.1334 mL | 0.6670 mL | 1.3340 mL | 3.3351 mL | |
| 30 mM | 0.1112 mL | 0.5559 mL | 1.1117 mL | 2.7793 mL | |
| 40 mM | 0.0834 mL | 0.4169 mL | 0.8338 mL | 2.0844 mL | |
| 50 mM | 0.0667 mL | 0.3335 mL | 0.6670 mL | 1.6676 mL | |
| 60 mM | 0.0556 mL | 0.2779 mL | 0.5559 mL | 1.3896 mL | |
| 80 mM | 0.0417 mL | 0.2084 mL | 0.4169 mL | 1.0422 mL | |
| 100 mM | 0.0334 mL | 0.1668 mL | 0.3335 mL | 0.8338 mL |
Wy-45494 hydrochloride Related Classifications
HY-131527 Related Classifications
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