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Cat. No.: HY-118788

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N-Desmethyl rosiglitazone

(Synonyms: SB 237216)

N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386).

For research use only. We do not sell to patients.

CAS No.: 257892-31-2
Formula: C₁₇H₁₇N₃O₃S
Molecular Weight:343.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

N-Desmethyl rosiglitazone Chemical Structure

CAS No.: 257892-31-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PPAR Isoforms :

All Cytochrome P450 Isoforms :

Chemical Information

CAS No. 257892-31-2
Molecular Weight 343.40
Formula C₁₇H₁₇N₃O₃S
SMILES

O=C1SC(CC2=CC=C(C=C2)OCCNC3=NC=CC=C3)C(N1)=O
Synonyms

SB 237216
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Calixto LA, et al. Simultaneous determination of rosiglitazone and its metabolites in rat liver microsomal fraction using hollow-fiber liquid-phase microextraction for sample preparation. J Sep Sci. 2010 Sep;33(17-18):2872-80. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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N-Desmethyl rosiglitazone

All PPAR Isoforms

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

N-Desmethyl rosiglitazone Related Classifications

HY-118788 Related Classifications