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5,6-Dihydro-5-Fluorouracil

(Synonyms: 5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione; 5-Fluorodihydrouracil)
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5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.

For research use only. We do not sell to patients.

  • Purity: 99.9%
  • CAS No.: 696-06-0
  • Formula: C4H5FN2O2
  • Molecular Weight:132.09
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 5,6-Dihydro-5-Fluorouracil Chemical Structure
    5,6-Dihydro-5-Fluorouracil Chemical Structure
CAS No.: 696-06-0
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  • 5,6-Dihydro-5-Fluorouracil Chemical Structure
    5,6-Dihydro-5-Fluorouracil Chemical Structure
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  • 5,6-Dihydro-5-Fluorouracil