1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. Tegafur

Tegafur (Synonyms: FT 207; NSC 148958)

Cat. No.: HY-17400 Purity: 99.96%
Handling Instructions

Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.

For research use only. We do not sell to patients.

Tegafur Chemical Structure

Tegafur Chemical Structure

CAS No. : 17902-23-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 87 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 79 In-stock
Estimated Time of Arrival: December 31
500 mg USD 144 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.

IC50 & Target

Nucleoside antimetabolite/analog

In Vitro

Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

200.17

Formula

C₈H₉FN₂O₃

CAS No.
SMILES

O=C1NC(C(F)=CN1C2OCCC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 48 mg/mL (239.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9958 mL 24.9788 mL 49.9575 mL
5 mM 0.9992 mL 4.9958 mL 9.9915 mL
10 mM 0.4996 mL 2.4979 mL 4.9958 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Keywords:

TegafurFT 207 NSC 148958FT207FT-207NSC148958NSC 148958NSC-148958Nucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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Tegafur
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HY-17400
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