696-06-0
696-06-0
Chemical Structure
5,6-Dihydro-5-Fluorouracil
Synonym(s): 5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione; 5-Fluorodihydrouracil
- CAS No.: 696-06-0
- Formula:C4H5FN2O2
- Molecular Weight:132.09
IUPAC Name: 5-fluorodihydropyrimidine-2,4(1H,3H)-dione
InChIKey: RAIRJKWTBBDDAR-UHFFFAOYSA-N
SMILES: O=C1NC(C(F)CN1)=O
Biological Activity: 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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5,6-Dihydro-5-Fluorouracil | 99.90% | 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model. | ||||||||||||||||||||
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5,6-Dihydro-5-Fluorouracil-13C,15N2 | 5,6-Dihydro-5-Fluorouracil-13C,15N2 (5-DHFU-13C,15N2) is the 13C- and 15N-labeled labeled 5,6-Dihydro-5-Fluorouracil (HY-134160). 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model. | |||||||||||||||||||||
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Cyclo(Ala-Gly) | 95.84% | Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM. | ||||||||||||||||||||
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5,6-Dihydro-5-methyluracil (Standard) | ≥98% | 5,6-Dihydro-5-methyluracil (Dihydrothymine) (Standard) is the analytical standard of 5,6-Dihydro-5-methyluracil (HY-N6787). This product is intended for research and analytical applications. 5,6-Dihydro-5-methyluracil is an intermediate breakdown product of Thymine (HY-W010450). 5,6-Dihydro-5-methyluracil can be used as a marker of DNA damage. 5,6-Dihydro-5-methyluracil can be used for the research of COVID-19. | ||||||||||||||||||||
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Hydantoin | Hydantoin is an imidazolidine-2,4-dione and serves as the parent nucleus of the antiepileptic agent Phenytoin (HY-B0448). | |||||||||||||||||||||
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Dihydrouracil (Standard) | 99.90% | Dihydrouracil (Standard) is the analytical standard of Dihydrouracil. This product is intended for research and analytical applications. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | ||||||||||||||||||||
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Dihydrouracil-13C4,15N2 | 98% | Dihydrouracil-13C4,15N2 is the 13C and 15N labeled Dihydrouracil. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | ||||||||||||||||||||
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5-Methylhydantoin | 5-Methylhydantoin is a hydantoin derivative, can be used in the synthesis of several pharmaceutical drugs. | |||||||||||||||||||||
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Imidazolidine-2,4-dione-13C,15N | Imidazolidine-2,4-dione-13C,15N (Hydantoin-13C,15N) is the 13C- and 15N-labeled Imidazolidine-2,4-dione (HY-W010612). | |||||||||||||||||||||
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Dihydrouracil-13C,15N2 | Dihydrouracil-13C,15N2 (5,6-Dihydrouracil-13C,15N2) is the 13C- and 15N-labeled Dihydrouracil (HY-W012926). Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. | |||||||||||||||||||||
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CRBN ligand-887 | CRBN ligand-887 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-887 can be linked to a target protein ligand via a linker to form a PROTAC. | |||||||||||||||||||||
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