Dihydrouracil-13C,15N2
Dihydrouracil-13C,15N2 (5,6-Dihydrouracil-13C,15N2) is the 13C- and 15N-labeled Dihydrouracil (HY-W012926). Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient.
For research use only. We do not sell to patients.
- CAS No.: 181516-96-1
- Formula: C313CH615N2O2
- Molecular Weight:117.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 181516-96-1
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Unlabeled Cas 504-07-4
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Molecular Weight 117.08
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Formula C313CH615N2O2
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SMILES
O=C([15NH][13C]1=O)CC[15N]1[H]
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Synonyms
5,6-Dihydrouracil-13C,15N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769. [Content Brief]
[2]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydrouracil-13C,15N2 Related Classifications
HY-W779020 Related Classifications
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