Regorafenib N-oxide and N-desmethyl (M5)
Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4.
For research use only. We do not sell to patients.
- CAS No.: 835621-12-0
- Formula: C20H13ClF4N4O4
- Molecular Weight:484.79
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-I0678
Regorafénib N-oxyde (M2) -
HY-I0678R
Regorafénib N-oxyde (M2) (Standard) -
HY-13342AS
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HY-119367
ODM-203 -
HY-103274
PD180970 -
HY-107417
Hypothemycin -
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N-Desethyl Sunitinib -
HY-13892
Dovitinib dilactic acid -
HY-10873R
N-Desethyl Sunitinib (Standard) -
HY-113632
Debromohymenialdisine
All VEGFR Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 835621-12-0
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Appearance Solid
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Molecular Weight 484.79
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Formula C20H13ClF4N4O4
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Color Light yellow to orange
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SMILES
O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=CC=[N+]1[O-])N
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Synonyms
N-Desmethyl regorafenib N-oxide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 8.33 mg/mL (17.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0627 mL | 10.3137 mL | 20.6275 mL | 51.5687 mL |
| 5 mM | 0.4125 mL | 2.0627 mL | 4.1255 mL | 10.3137 mL | |
| 10 mM | 0.2063 mL | 1.0314 mL | 2.0627 mL | 5.1569 mL | |
| 15 mM | 0.1375 mL | 0.6876 mL | 1.3752 mL | 3.4379 mL |
Regorafenib N-oxide and N-desmethyl (M5) Related Classifications
HY-108226 Related Classifications
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