Debromohymenialdisine
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation.
For research use only. We do not sell to patients.
- CAS No.: 75593-17-8
- Formula: C11H11N5O2
- Molecular Weight:245.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All MEK Isoforms
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Biological Activity
IC50: 881 nM (in Raf/MEK-1/MAPK signaling cascade assay)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A498 | ED50 |
24.7 μg/mL
Compound: 2
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Cytotoxicity against human A498 cells by SRB assay
Cytotoxicity against human A498 cells by SRB assay
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[PMID: 9051914] |
| Caco-2 | IC50 |
>10000 nM
Compound: 3
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Inhibition of human adenocarcinoma cell line Caco-2 proliferation
Inhibition of human adenocarcinoma cell line Caco-2 proliferation
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[PMID: 11784156] |
| KM-20L2 | ED50 |
8.5 μg/mL
Compound: 2
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Cytotoxicity against human KM20L2 cells by SRB assay
Cytotoxicity against human KM20L2 cells by SRB assay
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[PMID: 9051914] |
| L5178Y | EC50 |
1.8 μg/mL
Compound: 1d; DBH
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Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
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[PMID: 33901899] |
| LoVo | IC50 |
>10000 nM
Compound: 3
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Inhibition of human adenocarcinoma cell line LoVo proliferation
Inhibition of human adenocarcinoma cell line LoVo proliferation
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[PMID: 11784156] |
| MCF7 | IC50 |
25 μM
Compound: K00230, Debromohymenialdisine
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 18077363] |
| MONO-MAC-6 | IC50 |
9.67 μM
Compound: 7
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Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
|
[PMID: 36496202] |
| MONO-MAC-6 | IC50 |
2.4 μg/mL
Compound: 5
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Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
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[PMID: 9917317] |
| NCI-H460 | ED50 |
42 μg/mL
Compound: 2
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Cytotoxicity against human H460 cells by SRB assay
Cytotoxicity against human H460 cells by SRB assay
|
[PMID: 9051914] |
| OVCAR-3 | ED50 |
1.8 μg/mL
Compound: 2
|
Cytotoxicity against human OVCAR-3 cells by SRB assay
Cytotoxicity against human OVCAR-3 cells by SRB assay
|
[PMID: 9051914] |
| SF-295 | ED50 |
38.9 μg/mL
Compound: 2
|
Cytotoxicity against human SF295 cells by SRB assay
Cytotoxicity against human SF295 cells by SRB assay
|
[PMID: 9051914] |
| SK-MEL-5 | ED50 |
5.7 μg/mL
Compound: 2
|
Cytotoxicity against human SK-MEL-5 cells by SRB assay
Cytotoxicity against human SK-MEL-5 cells by SRB assay
|
[PMID: 9051914] |
Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 75593-17-8
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Molecular Weight 245.24
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Formula C11H11N5O2
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SMILES
NC(N/C1=C2CCNC(C3=C/2C=CN3)=O)=NC1=O
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Synonyms
10Z-Debromohymenialdisine
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Structure Classification
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Initial Source
Stylissa massa
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)