Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana

  • J Nat Prod. 1997 Feb;60(2):180-3. doi: 10.1021/np9606106.
G R Pettit  1 ,  J McNulty ,  D L Herald ,  D L Doubek ,  J C Chapuis ,  J M Schmidt ,  L P Tackett ,  M R Boyd
Affiliations
  • 1. Department of Chemistry, Arizona State University, Tempe 85287-2404, USA.
PMID: 9051914 DOI: 10.1021/np9606106
Abstract

Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles Sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.