1. Protein Tyrosine Kinase/RTK
  2. FGFR
    VEGFR
  3. ODM-203

ODM-203 

Cat. No.: HY-119367 Purity: 99.33%
Handling Instructions

ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity.

For research use only. We do not sell to patients.

ODM-203 Chemical Structure

ODM-203 Chemical Structure

CAS No. : 1430723-35-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 440 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity[1].

IC50 & Target[1]

FGFR1

11 nM (IC50)

FGFR2

16 nM (IC50)

FGFR3

6 nM (IC50)

FGFR4

35 nM (IC50)

VEGFR1

26 nM (IC50)

VEGFR2

9 nM (IC50)

VEGFR3

5 nM (IC50)

DDR1

6 nM (IC50)

RET

8 nM (IC50)

SIK3

23 nM (IC50)

PDGFRa

35 nM (IC50)

MINK1

41 nM (IC50)

MAP4K4

49 nM (IC50)

Clinical Trial
Molecular Weight

505.54

Formula

C₂₆H₂₁F₂N₅O₂S

CAS No.

1430723-35-5

SMILES

CN(N=C1)C=C1C2=CC=C3C(N=CN3C4=CC(C5=CC=C(F)C=C5F)=CC(NS(C6CC6)(=O)=O)=C4)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (131.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9781 mL 9.8904 mL 19.7808 mL
5 mM 0.3956 mL 1.9781 mL 3.9562 mL
10 mM 0.1978 mL 0.9890 mL 1.9781 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.33%

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Keywords:

ODM-203ODM203ODM 203FGFRVEGFRFibroblast growth factor receptorVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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Product Name:
ODM-203
Cat. No.:
HY-119367
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