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Results for "

metal chelators

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MOFs (2) ADC Linker (2) Akt (4) Amino Acid Derivatives (1) Amyloid-β (2) Antibiotic (2) Apoptosis (13) Autophagy (6) Bacterial (4) Beta-lactamase (1) Biochemical Assay Reagents (23) Cholinesterase (ChE) (5) CMV (1) Cuproptosis (3) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (4) Environmental Pollutants (4) Fluorescent Dye (3) Fungal (2) GABA Receptor (2) HDAC (2) HIF/HIF Prolyl-Hydroxylase (4) Isotope-Labeled Compounds (4) MDM-2/p53 (1) Mitochondrial Metabolism (1) Mitosis (1) MMP (4) Monoamine Oxidase (1) PSMA (3) Radionuclide-Drug Conjugates (RDCs) (13) Reactive Oxygen Species (ROS) (10) Reference Standards (11) SOD (1) Tau Protein (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (1) Infection (13) Inflammation/Immunology (13) Metabolic Disease (6) Neurological Disease (19)
Oligonucleotides:	Flavoring Agents (1) Sweetening Agents (1)

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Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Targets Recommended: MOFs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0988

Deferoxamine mesylate Maximum Cited Publications 397 Publications Verification Desferrioxamine B mesylate; DFOM	Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

HY-B1625

Deferoxamine Maximum Cited Publications 397 Publications Verification Deferoxamine B; Deferriferrioxamine B; Deferrioxamine	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt Autophagy	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

HY-W004544

o-Phenanthroline 5 Publications Verification 1,10-Phenanthroline	Environmental Pollutants MMP	Others
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .

HY-B0300

Penicillamine 3 Publications Verification D-(-)-Penicillamine	Cuproptosis Drug Metabolite	Inflammation/Immunology Cancer
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-100202

TPEN 20+ Cited Publications TPEDA	MOFs Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn ²⁺, but a lower affinity for Mg ²⁺ and Ca ²⁺. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis .

HY-W087187

DOTAGA-anhydride	Radionuclide-Drug Conjugates (RDCs) Biochemical Assay Reagents	Infection Cancer
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging .

HY-B1005

8-Hydroxyquinoline 1 Publications Verification 8-Quinolinol	Environmental Pollutants Antibiotic Bacterial	Cancer
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .

HY-Y1841

o-Phenanthroline monohydrate 5 Publications Verification 1,10-Phenanthroline monohydrate	MOFs MMP	Others
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .

HY-100138

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)	Radionuclide-Drug Conjugates (RDCs) ADC Linker	Cancer
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as ⁶⁸Ga, ¹⁷⁷Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .

HY-D0261

Tiron 1 Publications Verification	Biochemical Assay Reagents Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .

HY-N0928

Mimosine 4 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-W012788

Maltol 2 Publications Verification	Environmental Pollutants Endogenous Metabolite Apoptosis	Infection Neurological Disease
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-16739

Emeramide NBMI; BDTH2	Cuproptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Emeramide is a thiol-redox antioxidant and heavy metal chelator .

HY-Y0682S

Ethylenediaminetetraacetic acid-d12 EDTA-d₁₂	Isotope-Labeled Compounds	Neurological Disease
Ethylenediaminetetraacetic acid-d₁₂ is the deuterium labeled Ethylenediaminetetraacetic acid . Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds .

HY-128370

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	CMV	Infection
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .

HY-164569

NH2 DOTA-GA	Radionuclide-Drug Conjugates (RDCs)	Cancer
NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions, for example, NH2 DOTA-GA complexes Gd(III) ions.

HY-D0836

EDTA dipotassium dihydrate Maximum Cited Publications 28 Publications Verification Ethylenediaminetetraacetic acid dipotassium dihydrate	DNA/RNA Synthesis	Others
EDTA dipotassium dihydrate is a metal ion chelator that forms stable and water-soluble chelates with a variety of metal ions. EDTA dipotassium is commonly used as a blood anticoagulant, which can effectively prevent blood coagulation and maintain the morphology and function of cells in blood samples. In the industrial field, EDTA dipotassium can be used to remove the adverse effects of metal ions and prevent oxidation and deterioration caused by metal ions .

HY-W047709

N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine THEED; THEEN	Biochemical Assay Reagents Bacterial Fungal	Infection Cancer
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED; THEEN) is a tetrapodal pentadentate chelating ligand that functions as a chelator to form stable complexes with metal ions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine serves as a versatile building block for organic synthesis, a reagent for metal extraction, and an auxiliary for catalytic reactions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine-derived metal complexes exhibit antibacterial, antifungal, and anticancer activities. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine and its metal complexes can be used for research related to breast cancer, leukemia, various bacterial and fungal infections .

HY-126823

Phen Green SK diacetate (5/6-mixture) 10+ Cited Publications PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe ²⁺, Cd ²⁺, Co ²⁺, Ni ²⁺, Zn ²⁺, etc. Phen green SK (PGSK) diacetate chelates Fe ²⁺, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents	Others
Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-20512

N,N'-Dibenzylethylenediamine	Biochemical Assay Reagents	Others
N,N'-Dibenzylethylenediamine forms chelator with metals. N,N'-Dibenzylethylenediamine interacts with penicillin, forms a stable and tasteless salt of penicillin .

HY-B0988R

Deferoxamine mesylate (Standard) Desferrioxamine B mesylate (Standard); DFOM (Standard)	Reference Standards Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine (mesylate) (Standard) is the analytical standard of Deferoxamine (mesylate). This product is intended for research and analytical applications. Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

HY-W012683

Iminodiacetic acid	Biochemical Assay Reagents	Cancer
Iminodiacetic acid is a metal ion chelator targeting Cr ⁶⁺, Cd ²⁺, Ni ²⁺, and Pb ²⁺. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-D0179

Cyclam	Biochemical Assay Reagents	Infection Cardiovascular Disease
Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities .

HY-D1746

EDTA-AM 2 Publications Verification EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester	Biochemical Assay Reagents Mitosis	Others
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .

HY-W755033

NH2-PEG4-DOTA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Others
NH2-PEG4-DOTA is a bifunctional DOTA chelator with one carboxyl group modified by NH2-PEG4, possessing both a metal-binding domain and a chemically reactive functional group. NH2-PEG4-DOTA can be used for time-resolved fluorescence assays .

HY-103528

SCS Salicylidene salicylhydrazide	GABA Receptor	Neurological Disease Inflammation/Immunology
SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABA_A receptors with an IC₅₀ of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions .

HY-B0658A

Zinc acetate dihydrate, ACS, 98% Zinc(II) acetate dihydrate, ACS, 98%	Biochemical Assay Reagents	Others
Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

HY-18670

HQ-415	Radionuclide-Drug Conjugates (RDCs)	Neurological Disease
HQ-415 is a biologically active metal chelator related to Clioquinol (HY-14603), with an EC₅₀ of 15 μM.

HY-45290

trans-1,2-Cyclohexanediaminetetraacetic acid	Biochemical Assay Reagents	Others
trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions .

HY-158072

DOTAM-NHS-ester	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development .

HY-W250119

Calcium disodium edetate hydrate 20+ Cited Publications EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate	Biochemical Assay Reagents Fungal Mitochondrial Metabolism	Infection
Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn ²⁺, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents	Others
Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

HY-W105699

EDTA tetrasodium tetrahydrate Ethylenediaminetetraacetic acid tetrasodium tetrahydrate	Environmental Pollutants Biochemical Assay Reagents	Others
EDTA tetrasodium tetrahydrate is a metal chelator (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. EDTA tetrasodium tetrahydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA tetrasodium tetrahydrate can also decrease the formation of disulfide bonds .

HY-Y0682S1

Ethylenediaminetetraacetic acid-d16 EDTA-d₁₆	Isotope-Labeled Compounds	Neurological Disease
Ethylenediaminetetraacetic acid-d₁₆ is the deuterium labeled Ethylenediaminetetraacetic acid . Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds .

HY-164732

Fmoc-Lys(DOTA)-OH	Amino Acid Derivatives Biochemical Assay Reagents	Others
Fmoc-Lys (DOTA)-OH is an Fmoc-protected Lysine derivative with metal-chelating properties, containing the macrocyclic chelator DOTA. Fmoc-Lys (DOTA)-OH undergoes metallation with Tb or Lu. Fmoc-Lys (DOTA)-OH utilizes metal coordination to protect the carboxyl groups of DOTA. Fmoc-Lys (DOTA)-OH can be used in solid-phase peptide synthesis research .

HY-B1625R

Deferoxamine (Standard) 3 Publications Verification Deferoxamine B (Standard); Deferriferrioxamine B (Standard); Deferrioxamine (Standard)	Reference Standards HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt Autophagy	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine (Standard) is the analytical standard of Deferoxamine. This product is intended for research and analytical applications. Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

HY-W110776

Zinc oxinate Bis(8-quinolinolato)zinc(II) hydrate; Zinc 8-hydroxyquinolinate	Biochemical Assay Reagents	Others
Zinc oxinate (Zinc 8-hydroxyquinolinate) is a metal chelator that stabilizes zinc complexes by forming pentacoordinate or hexacoordinate adducts. Zinc oxinate is promising for research of zinc quantification .

HY-132927B

Salpyran dihydrochloride	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Salpyran dihydrochloride is a Cu(II) selective chelator with therapeutic potential. Salpyran dihydrochloride prevents the formation of reactive oxygen species from the binary Cu(II)/H₂O₂ system .

HY-131673

p-SCN-Bn-TCMC tetrahydrochloride	Biochemical Assay Reagents	Others
p-SCN-Bn-TCMC tetrahydrochloride is a bifunctional chelator that exhibits high reactivity due to its powerful TCMC component, making it effective for binding radio-isotopic heavy metal ions, which are essential in radio-diagnostic imaging applications.

HY-144659

Metallo-β-lactamase-IN-5	Beta-lactamase Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .

HY-W241345

DOTA-bis(tert-butyl)ester	Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.

HY-D1641

5,5'-Dimethyl BAPTA tetrapotassium	Fluorescent Dye	Others
5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .

HY-164575

NH2-NODAGA	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
NH2-NODAGA is a NODAGA-type metal chelator that can bind to radionuclides to prepare radionuclide conjugates (RDCs). NH2-NODAGA can react with diethyl squarate in 0.5M phosphate buffer to obtain NODAGA.SA. NODAGA.SA can target L-lysine urea-L-glutamate (KuE), which is a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can bind [68]Ga and can be used for PET examination of NMRInu/nu nude mice bearing LNCaP tumors.

HY-W1113135

Carboxymethyl-β-cyclodextrin sodium salt	Biochemical Assay Reagents	Others
Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba ²⁺, Ca ²⁺, Cd ²⁺, Ni ²⁺, Pb ²⁺, Sr ²⁺, and Zn ²⁺ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research .

HY-W012683R

Iminodiacetic acid (Standard)	Biochemical Assay Reagents Reference Standards	Cancer
Iminodiacetic acid is a metal ion chelator targeting Cr6+, Cd2+, Ni2+, and Pb2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-N0928R

Mimosine (Standard)	Reference Standards Apoptosis	Inflammation/Immunology Cancer
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-W012788R

Maltol (Standard)	Reference Standards Endogenous Metabolite Apoptosis	Infection Neurological Disease
Maltol (Standard) is the analytical standard of Maltol. This product is intended for research and analytical applications. Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-W087187G

DOTAGA-anhydride	Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTAGA-anhydride (GMP) is DOTAGA-anhydride (HY-W087187) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging .

HY-B1005R

8-Hydroxyquinoline (Standard) 8-Quinolinol (Standard)	Reference Standards Bacterial Antibiotic	Cancer
8-Hydroxyquinoline (Standard) is the analytical standard of 8-Hydroxyquinoline. This product is intended for research and analytical applications. 8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .

Cat. No.	Product Name	Type

HY-D1746

EDTA-AM

2 Publications Verification

EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester

Fluorescent Dyes

EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .

HY-D1641

5,5'-Dimethyl BAPTA tetrapotassium	Fluorescent Dyes
5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .

HY-W087187G

DOTAGA-anhydride

Fluorescent Dyes

DOTAGA-anhydride (GMP) is DOTAGA-anhydride (HY-W087187) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging .

Cat. No.	Product Name	Type

HY-W004544

o-Phenanthroline 5 Publications Verification 1,10-Phenanthroline	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .

HY-Y1841

o-Phenanthroline monohydrate 5 Publications Verification 1,10-Phenanthroline monohydrate	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .

HY-D0836

EDTA dipotassium dihydrate

Maximum Cited Publications

28 Publications Verification

Ethylenediaminetetraacetic acid dipotassium dihydrate

Biochemical Assay Reagents

EDTA dipotassium dihydrate is a metal ion chelator that forms stable and water-soluble chelates with a variety of metal ions. EDTA dipotassium is commonly used as a blood anticoagulant, which can effectively prevent blood coagulation and maintain the morphology and function of cells in blood samples. In the industrial field, EDTA dipotassium can be used to remove the adverse effects of metal ions and prevent oxidation and deterioration caused by metal ions .

HY-W011060

Cryptand 2.2.2

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane

Biochemical Assay Reagents

Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-20512

N,N'-Dibenzylethylenediamine	Biochemical Assay Reagents
N,N'-Dibenzylethylenediamine forms chelator with metals. N,N'-Dibenzylethylenediamine interacts with penicillin, forms a stable and tasteless salt of penicillin .

HY-B0658A

Zinc acetate dihydrate, ACS, 98%

Zinc(II) acetate dihydrate, ACS, 98%

Biochemical Assay Reagents

Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

HY-45290

trans-1,2-Cyclohexanediaminetetraacetic acid	Biochemical Assay Reagents
trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions .

HY-158072

DOTAM-NHS-ester	Biochemical Assay Reagents
DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development .

HY-W250119

Calcium disodium edetate hydrate

20+ Cited Publications

EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate

Biochemical Assay Reagents

Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn ²⁺, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5

Biochemical Assay Reagents

Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

HY-W087187G

DOTAGA-anhydride

Biochemical Assay Reagents

HY-Y1841R

o-Phenanthroline monohydrate (Standard)	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0300

Penicillamine 3 Publications Verification D-(-)-Penicillamine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields Source Classification	Cuproptosis Drug Metabolite
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-N0928

Mimosine 4 Publications Verification	Natural Products other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-W012788

Maltol 2 Publications Verification	Panax ginseng C. A. Meyer Structural Classification Natural Products Classification of Application Fields Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Apoptosis
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-W012683

Iminodiacetic acid	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Biochemical Assay Reagents
Iminodiacetic acid is a metal ion chelator targeting Cr ⁶⁺, Cd ²⁺, Ni ²⁺, and Pb ²⁺. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-W012683R

Iminodiacetic acid (Standard)	Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Biochemical Assay Reagents Reference Standards
Iminodiacetic acid is a metal ion chelator targeting Cr6+, Cd2+, Ni2+, and Pb2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-N0928R

Mimosine (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Apoptosis
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-W012788R

Maltol (Standard)	Panax ginseng C. A. Meyer Structural Classification Microorganisms Ketones, Aldehydes, Acids Plants Endogenous metabolite Araliaceae Source Classification	Reference Standards Endogenous Metabolite Apoptosis
Maltol (Standard) is the analytical standard of Maltol. This product is intended for research and analytical applications. Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-B0300R

Penicillamine (Standard) D-(-)-Penicillamine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Cuproptosis Reference Standards Drug Metabolite
Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

Cat. No.	Product Name	Chemical Structure

HY-Y0682S

Ethylenediaminetetraacetic acid-d12

Ethylenediaminetetraacetic acid-d₁₂ is the deuterium labeled Ethylenediaminetetraacetic acid . Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds .

HY-Y0682S1

Ethylenediaminetetraacetic acid-d16

Ethylenediaminetetraacetic acid-d₁₆ is the deuterium labeled Ethylenediaminetetraacetic acid . Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds .

HY-W004544S

o-Phenanthroline-d8
o-Phenanthroline-d₈ is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .

HY-W012788S

Maltol-d3

Maltol-d₃ is a deuterium labeled Maltol (HY-W012788). Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

Cat. No.	Product Name		Classification

HY-W012788

Maltol 2 Publications Verification		Sweetening Agents Flavoring Agents
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

Targets Recommended: MOFs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W087187G

DOTAGA-anhydride	Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTAGA-anhydride (GMP) is DOTAGA-anhydride (HY-W087187) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging .

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