N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine
Based on 1 Customer Validation
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED; THEEN) is a tetrapodal pentadentate chelating ligand that functions as a chelator to form stable complexes with metal ions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine serves as a versatile building block for organic synthesis, a reagent for metal extraction, and an auxiliary for catalytic reactions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine-derived metal complexes exhibit antibacterial, antifungal, and anticancer activities. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine and its metal complexes can be used for research related to breast cancer, leukemia, various bacterial and fungal infections.
For research use only. We do not sell to patients.
- Purity : 99.89%
- CAS No.: 140-07-8
- Formula: C10H24N2O4
- Molecular Weight:236.31
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (as its copper(II) complexes) shows inhibitory effects against Staphylococcus aureus, Serratia marcescens, Sphingobium japonicum, Stenotrophomonas maltophilia, Candida albicans, Aspergillus niger, and Saccharomyces cerevisiae with minimum inhibitory concentrations ranging from 25 to 50 μg/mL[1][2][3].
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (as its copper(II) complexes) (48 h) shows in vitro antiproliferative activity against MCF-7, HL-60 and HCT-116 cancer cells[1].
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (as its copper(II) complexes) (48 h) exhibits potent cytotoxicity against MCF-7 breast cancer cells with an IC50 value of 23 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 140-07-8
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Appearance Liquid (Density: 1.193±0.06 g/cm3)
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Molecular Weight 236.31
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Formula C10H24N2O4
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Color Colorless to light yellow
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SMILES
OCCN(CCO)CCN(CCO)CCO
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Synonyms
THEED; THEEN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (846.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2317 mL | 21.1586 mL | 42.3173 mL | 105.7932 mL |
| 5 mM | 0.8463 mL | 4.2317 mL | 8.4635 mL | 21.1586 mL | |
| 10 mM | 0.4232 mL | 2.1159 mL | 4.2317 mL | 10.5793 mL | |
| 15 mM | 0.2821 mL | 1.4106 mL | 2.8212 mL | 7.0529 mL | |
| 20 mM | 0.2116 mL | 1.0579 mL | 2.1159 mL | 5.2897 mL | |
| 25 mM | 0.1693 mL | 0.8463 mL | 1.6927 mL | 4.2317 mL | |
| 30 mM | 0.1411 mL | 0.7053 mL | 1.4106 mL | 3.5264 mL | |
| 40 mM | 0.1058 mL | 0.5290 mL | 1.0579 mL | 2.6448 mL | |
| 50 mM | 0.0846 mL | 0.4232 mL | 0.8463 mL | 2.1159 mL | |
| 60 mM | 0.0705 mL | 0.3526 mL | 0.7053 mL | 1.7632 mL | |
| 80 mM | 0.0529 mL | 0.2645 mL | 0.5290 mL | 1.3224 mL | |
| 100 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0579 mL |
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine Related Classifications
HY-W047709 Related Classifications
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Keywords
- N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine
- 140-07-8
- THEED
- THEEN
- Biochemical Assay Reagents
- Bacterial
- Fungal
- Candida albicans
- Gram-negative bacteria
- Aspergillus niger
- Gram-positive bacteria
- breast cancer
- Staphylococcus aureus
- Serratia marcescens
- Saccharomyces cerevisiae
- fungal species
- leukemia
- Inhibitor
- inhibitor
- inhibit