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Quadrol (Synonyms: N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine; EDTP)

Cat. No.: HY-B2149 Purity: >98.0%
Handling Instructions

Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing.

For research use only. We do not sell to patients.

Quadrol Chemical Structure

Quadrol Chemical Structure

CAS No. : 102-60-3

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 g USD 50 In-stock
Estimated Time of Arrival: December 31
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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing.

In Vitro

Results show that viability of macrophages incubated with Quadrol at concentrations of 0.5 mM, 1 mM and 4mM are identical to that for controls. Viability, however, is reduced to 50% of control at concentrations of 16 mM to 32 mM. After four hours, at concentrations of 1 mM and 4 mM, Quadrol produces enhanced spreading of 88% and 80%, respectively, as compared to the control of 28%. Quadrol, at a concentration of 16 mM, shows reduced percentage of spreading of macrophages after four hours. Exposure of macrophages to 1.0 mM or 4.0 mM Quadrol concentrations enhances phagocytic activity, 41% and 57%, respectively, over that of the cells exposed to media alone (34%)[1].

In Vivo

On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5)[2].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (284.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4199 mL 17.0993 mL 34.1986 mL
5 mM 0.6840 mL 3.4199 mL 6.8397 mL
10 mM 0.3420 mL 1.7099 mL 3.4199 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The standard trypan blue exclusion test is performed to measure cell viability (10). Cells are exposed to increasing concentrations of Quadrol (0.5 mM to 32 mM) and incubated at 37°C for varying lengths of time before treatment with trypan blue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

At the time of polytetrafluoroethylene (PTFE) tubing implantation, six test groups (3 streptozotocin-induced (STZ) diabetic and 3 non-diabetic) consisting of 5 to 7 animals per sampling time receive either diluent (control group) or Quadrol (10 mM) injected approximately 1 cm from the implantation site. The PTFE implants recovered from the mice after 2 to 14 days are stored frozen until processed and then analyzed by the HPLC method[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

292.41

Formula

C₁₄H₃₂N₂O₄

CAS No.

102-60-3

SMILES

CC(O)CN(CC(O)C)CCN(CC(O)C)CC(O)C

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Quadrol
Cat. No.:
HY-B2149
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Quadrol

Cat. No.: HY-B2149