BChE/HDAC6-IN-2
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
For research use only. We do not sell to patients.
- CAS No.: 2925457-33-4
- Formula: C27H30N4O4
- Molecular Weight:474.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)
BChE/HDAC6-IN-2 (compound 29a) (0.1 μM, 1 μM; 24 h) increases the acetylation levels of Ac-α-tubulin, inhibits phosphorylation of tau, in 10 μM Aβ(1-42)-treated SH-SY5Y cells[1].
BChE/HDAC6-IN-2 (5 μM, 10 μM, 20 μM) inhibits glutamate-induced injury in SH-SY5Y cells, shows neuroprotective effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2925457-33-4
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Molecular Weight 474.55
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Formula C27H30N4O4
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SMILES
O=C(NCC1=CC=CC=C1CN(CC)CC)C2=CC(NC(C3=CC(C(NO)=O)=CC=C3)=O)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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