BChE/HDAC6-IN-2
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
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- CAS 番号: 2925457-33-4
- 分子式: C27H30N4O4
- 分子量:474.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)
体外実験
BChE/HDAC6-IN-2 (compound 29a) (0.1 μM, 1 μM; 24 h) increases the acetylation levels of Ac-α-tubulin, inhibits phosphorylation of tau, in 10 μM Aβ(1-42)-treated SH-SY5Y cells[1].
BChE/HDAC6-IN-2 (5 μM, 10 μM, 20 μM) inhibits glutamate-induced injury in SH-SY5Y cells, shows neuroprotective effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2925457-33-4
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分子量 474.55
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分子式 C27H30N4O4
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SMILES
O=C(NCC1=CC=CC=C1CN(CC)CC)C2=CC(NC(C3=CC(C(NO)=O)=CC=C3)=O)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BChE/HDAC6-IN-2 関連分類
HY-149418 関連分類
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