1-Ethyl-2-methyl-3-hydroxypyrid-4-one
1-Ethyl-2-methyl-3-hydroxypyrid-4-one is an α-ketohydroxypyridinium iron chelator with high specificity for iron and no specific activity against other metal ions such as copper, zinc, calcium and magnesium. In rabbits with iron overload, 1-Ethyl-2-methyl-3-hydroxypyrid-4-one increased iron excretion after oral or parenteral administration.
For research use only. We do not sell to patients.
- CAS No.: 30652-12-1
- Formula: C8H11NO2
- Molecular Weight:153.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
Chemical Information
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CAS No. 30652-12-1
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Molecular Weight 153.18
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Formula C8H11NO2
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SMILES
O=C1C(O)=C(C)N(CC)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Perls' Prussian Blue Iron Staining
Perls' Prussian blue staining is a histochemical method used to detect non-heme ferric iron (Fe3+) in biological tissues by exploiting an acid-mediated release of loosely bound iron from storage complexes such as ferritin or hemosiderin, followed by its reaction with potassium ferrocyanide to form an insoluble blue ferric ferrocyanide (Prussian blue) precipitate that marks iron localization under light microscopy. The reaction is classically performed under acidic conditions, which liberate Fe3+ ions that subsequently bind ferrocyanide to generate the visible chromogen, enabling spatial visualization of iron deposits in tissues such as brain, liver, and spleen. Histochemical interpretations are limited to a reactive iron pool rather than total iron content, reflecting only histologically accessible iron species rather than tightly protein-bound iron.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Ethyl-2-methyl-3-hydroxypyrid-4-one Related Classifications
HY-W339484 Related Classifications
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