AChE/HDAC-IN-1
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2414053-06-6
- 分子式: C26H27ClN4O3
- 分子量:478.97
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
HDAC 0.23 nM (IC50) |
体外実験
COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively[1].
COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)[1].
COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 2414053-06-6
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分子量 478.97
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分子式 C26H27ClN4O3
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SMILES
O=C(NCCCNC1=C(CCCC2)C2=NC3=CC(Cl)=CC=C31)C4=CC=C(/C=C/C(NO)=O)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AChE/HDAC-IN-1 関連分類
HY-147962 関連分類
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