1. Apoptosis
  2. Apoptosis
  3. Mimosine

Mimosine 

Cat. No.: HY-N0928 Purity: 99.17%
Handling Instructions

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.

For research use only. We do not sell to patients.

Mimosine Chemical Structure

Mimosine Chemical Structure

CAS No. : 500-44-7

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25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
100 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.

In Vitro

Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore[2].
Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena[2].
Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa[4].
Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells[4].
Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mimosine (30, and 60 mg/kg) decreases sperm concentration[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR male mice (6-8 weeks)[5]
Dosage: 15, 30, or 60 mg/kg
Administration: Injected (i.p.) for 7 consecutive days
Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.
Molecular Weight

198.18

Formula

C₈H₁₀N₂O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.23 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0459 mL 25.2296 mL 50.4592 mL
5 mM 1.0092 mL 5.0459 mL 10.0918 mL
10 mM 0.5046 mL 2.5230 mL 5.0459 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Mimosine
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