AChE-IN-11
AChE-IN-11 (compound 5C) is a triple inhibitor targeting AChE/MAO-B/BACE1 (IC50=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C18H28N2O4
- Molecular Weight:336.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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AChE |
Chemical Information
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Molecular Weight 336.43
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Formula C18H28N2O4
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SMILES
[H][C@@](COC1=CC(O)=C(C=C1)C(C)=O)(CN2CCN(CC2)C(C)C)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Carbohydrates and Mucins: Periodic Acid-Schiff (PAS) Staining
Periodic acid-Schiff staining detects tissue carbohydrates and mucosubstances by oxidizing carbohydrate glycol groups with periodic acid to generate aldehydes, which then react with Schiff reagent to produce a magenta reaction product; classic reports established the method for mucin and polysaccharide-containing structures in fixed tissue sections. PAS staining can demonstrate neutral mucins and goblet-cell mucin, but it is not specific for mucin because glycogen and other PAS-positive tissue components can also stain; diastase/PAS-D is used when glycogen removal is needed to distinguish glycogen-dependent PAS signal from non-glycogen PAS-positive mucosubstances.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-11 Related Classifications
HY-115973 Related Classifications
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