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Results for "

oxidoreductases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (1) ADC Payload (1) Aldose Reductase (1) Aminotransferases (Transaminases) (1) AMPK (2) Antibiotic (1) Apoptosis (2) Bacterial (7) Biochemical Assay Reagents (30) Caspase (2) Cytochrome P450 (7) DNA Alkylator/Crosslinker (3) Drug Derivative (1) Drug Intermediate (2) Drug Metabolite (1) Endogenous Metabolite (23) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (1) Fluorescent Dye (3) Fungal (2) Isotope-Labeled Compounds (4) Keap1-Nrf2 (3) Lactate Dehydrogenase (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (7) MOFs (2) NADPH Oxidase (2) Parasite (6) PDHK (2) Pyroptosis (1) Quinone Reductase (15) Reactive Oxygen Species (ROS) (6) Reference Standards (5) STAT (1) Toll-like Receptor (TLR) (1) URAT1 (1) Xanthine Oxidase (14)
By Research Areas:	Cancer (26) Cardiovascular Disease (5) Endocrinology (3) Infection (15) Inflammation/Immunology (4) Metabolic Disease (57) Neurological Disease (5)
Click Chemistry:	Alkynes (1)

125

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15924

Thiazolyl Blue 180+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye	Others
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-N0645

Dicoumarol 10+ Cited Publications Dicumarol	Quinone Reductase PDHK	Cancer
Dicoumarol is an inhibitor of both *NAD(P)H:quinone oxidoreductase* 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-P2902

Glucose oxidase 5+ Cited Publications	Endogenous Metabolite	Cancer
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .

HY-P2755

Xanthine oxidase, Microorganism 5+ Cited Publications XO; XOD	Reactive Oxygen Species (ROS)	Inflammation/Immunology Endocrinology
Xanthine oxidase, Microorganism (XO) is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

HY-P2907

Formate dehydrogenase	Endogenous Metabolite	Others
Formate dehydrogenase is a class of oxidoreductases widely distributed in bacteria, fungi, plants and animals. Formate dehydrogenase catalyzes the reversible conversion between formic acid and carbon dioxide, accompanied by redox reactions of the coenzyme NAD ⁺/NADH or other electron carriers .

HY-P2755A

Xanthine oxidase, bovine milk	Reactive Oxygen Species (ROS)	Inflammation/Immunology Endocrinology
Xanthine oxidase, bovine milk is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

HY-125027

Isobutyl-deoxynyboquinone IB-DNQ	Quinone Reductase	Cancer
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer .

HY-P2807F

Lactate Dehydrogenase (LDH), Bovine Heart LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase	Lactate Dehydrogenase	Cardiovascular Disease
Lactate Dehydrogenase (LDH), Bovine Heart (LAD) is an oxidoreductase that catalyzes the reversible conversion between lactate and pyruvate. Lactate Dehydrogenase (LDH), Bovine Heart is mainly used in life science research, tissue damage diagnosis, and as an enzyme marker .

HY-14874

Topiroxostat 5+ Cited Publications FYX-051	MOFs Xanthine Oxidase Cytochrome P450	Metabolic Disease
Topiroxostat (FYX-051) is a potent and orally active *xanthine oxidoreductase* (XOR) inhibitor with an IC₅₀ value of 5.3 nM and a K_i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4**-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment .

HY-103667

2-HBA 3 Publications Verification	Quinone Reductase Caspase	Cancer
2-HBA is a potent inducer of *NAD(P)H:quinone acceptor oxidoreductase* 1 (NQO1) which can also activate caspase-3 and caspase-10**.

HY-P2897

D-Lactate dehydrogenase, Microorganism 1 Publications Verification D-LDH	Lactate Dehydrogenase	Others
D-Lactate dehydrogenase, Microorganism (D-LDH) is an oxidoreductase that uses NAD ⁺ or NADP ⁺ as an acceptor and acts on the donor CH-OH group, and can catalyze the oxidation of D-lactate to pyruvate. D-Lactate dehydrogenase widely exists in bacteria and fungi, and is often used in biochemical research .

HY-144439

HTS07545	Mitochondrial Metabolism	Cardiovascular Disease Cancer
HTS07545 is a potent *sulfide:quinone oxidoreductase* (SQOR) inhibitor with an IC₅₀** of 30 nM. HTS07545 reduces the decomposition rate of hydrogen sulfide (H₂S). HTS07545 can be used in the research of heart failure and pancreatic ductal adenocarcinoma.

HY-P3186A

NAD-dependent Glucose dehydrogenase GDH-NAD	Endogenous Metabolite	Metabolic Disease
NAD-dependent glucose dehydrogenase (GDH-NAD) is an oxidoreductase that uses NAD ⁺ as a coenzyme, specifically catalyzes the dehydrogenation of glucose to gluconolactone, and reduces NAD ⁺ to NADH. NAD-dependent glucose dehydrogenase exhibits favorable substrate selectivity and stability, and is not affected by oxygen .

HY-141552

FC9402 2 Publications Verification	Mitochondrial Metabolism	Cardiovascular Disease
FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .

HY-P2889

Pyranose oxidase, Coriolus sp.	Biochemical Assay Reagents	Others
Pyranose oxidase, Coriolus sp. is an *oxidoreductase* targeting monosaccharides (e.g., D-glucose, D-galactose). Pyranose oxidase, Coriolus sp. is promising for research of biosensors (glucose, 1,5-anhydroglucitol detection) and biofuel cells .

HY-135024

Phenylacetyl CoA Phenylacetyl Coenzyme A	Endogenous Metabolite	Metabolic Disease
Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica .

HY-148706

STAT3-IN-17	STAT	Infection Cancer
STAT3-IN-17 is a moderate STAT3 inhibitor (IC₅₀=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori .

HY-14572

PR-104A SN 27858	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .

HY-W007584

2,4-Dimethoxybenzyl alcohol	Drug Intermediate	Others
2,4-Dimethoxybenzyl alcohol, an aromatic alcohol, is a substrate of glucose-methanol-choline (GMC) oxidoreductase. GMC oxidoreductase displays the characteristics of an aryl-alcohol oxidase. 2,4-Dimethoxybenzyl alcohol can be used as a drug intermediate .

HY-118588

Diminutol	Quinone Reductase Microtubule/Tubulin	Others
Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision .

HY-P2743

Choline oxidase	Biochemical Assay Reagents	Others
Choline oxidase (EC 1.1.3.17) catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production .

HY-120338

RYL-552	Mitochondrial Metabolism Parasite	Infection
RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a *P. falciparum NADH dehydrogenase 2 (PfNDH2)* inhibtor .

HY-N5018

Nepodin Musizin	Parasite AMPK	Infection
Nepodin (Musizin) is a *quinone oxidoreductase* (PfNDH2)** inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-W016628

L-Gulono-1,4-lactone L-Gulonolactone	Endogenous Metabolite	Metabolic Disease
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-P2964

Phenylalanine dehydrogenase	Endogenous Metabolite	Metabolic Disease
Phenylalanine dehydrogenase is an NAD ⁺-dependent oxidoreductase targeting L-phenylalanine. Phenylalanine dehydrogenase catalyzes deamination to phenylpyruvate and NADH as part of amino acid metabolism regulation. Phenylalanine dehydrogenase is promising for research of phenylketonuria (PKU) .

HY-168926

NQO2-IN-1	Reactive Oxygen Species (ROS) Apoptosis	Cancer
NQO2-IN-1 (Compound 20b) is the inhibitor for quinone oxidoreductase (NQO) that inhibits NQO2 with an IC₅₀ of 95 nM. NQO2-IN-1 overcomes the resistance of NSCLC cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by induction of ROS and apoptosis .

HY-151975

*Xanthine oxidoreductase-IN-5*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-5 is an orally active *xanthine oxidoreductase* (XOR) inhibitor, with an IC₅₀** of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia .

HY-151973

*Xanthine oxidoreductase-IN-3*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-3 is an orally active *xanthine oxidoreductase* (XOR) inhibitor, with an IC₅₀** of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia .

HY-P2807K

L-Lactate Dehydrogenase, bovine muscle	Endogenous Metabolite	Metabolic Disease
L-Lactate Dehydrogenase, bovine muscle is an oxidoreductase. L-Lactate Dehydrogenase, bovine muscle catalyzes the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH .

HY-W012927

4-Hydroxy-5-methylfuran-3(2H)-one Chicory furaneol	Biochemical Assay Reagents	Others
4-Hydroxy-5-methylfuran-3(2H)-one (Chicory furaneol) can be used to assay oxidoreductase activity. 4-Hydroxy-5-methylfuran-3(2H)-one is a kind of biological materials or organic compounds that are widely used in life science research .

HY-157744

Coumarin–quinone conjugate	Mitochondrial Metabolism	Cancer
Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis .

HY-149769

CP-506	Cytochrome P450	Cancer
CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .

HY-W008356

2-Fluoro-4-iodobenzonitrile	Drug Intermediate	Infection Metabolic Disease
2-Fluoro-4-iodobenzonitrile is a building block, which can be used to synthesize L. infantum trypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors. 2-Fluoro-4-iodo benzonitrile can also be used to synthesize transient receptor potential ankyrin 1 (TRPA1) antagonists .

HY-W075315

*Xanthine oxidoreductase-IN-6*	MOFs Xanthine Oxidase Cytochrome P450	Metabolic Disease
Xanthine oxidoreductase-IN-6 (Compound 4) is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC₅₀ of 170 nM. Xanthine oxidoreductase-IN-6 can block the final step of uric acid biosynthesis and lower serum uric acid levels. Xanthine oxidoreductase-IN-6 also shows Cytochrome P450 3A4 (CYP3A4) inhibitory activity. Xanthine oxidoreductase-IN-6 can be used for the research of hyperuricemia .

HY-116433

Nequinate	Parasite Xanthine Oxidase	Infection Metabolic Disease
Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections . Nequinate inhibits xanthine oxidoreductase (XOD) activity .

HY-176757

N-Benzyl-N-demethylpronqodine A	NADPH Oxidase	Cancer
N-Benzyl-N-demethylpronqodine A (Compound 16) is an inhibitor of *NAD(P)H:quinine acceptor oxidoreductase* 1 (NQO1) with an IC₅₀** of 83.3 nM .

HY-145820

Tubulin inhibitor 14	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 14 is a potent *NQO2 (quinone oxidoreductase* 2) inhibitor with an IC₅₀** of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features .

HY-P2742A

L-Ascorbate oxidase, Cucumber	Endogenous Metabolite	Metabolic Disease
L-Ascorbate oxidase, Cucumber belongs to the family of oxidoreductases acting on diphenols and related substances as donor with oxygen as acceptor. L-Ascorbate oxidase, Cucumber catalyses the oxidation of L‐Ascorbate (HY-B0166) with oxygen to dehydroascorbate with the generation of water. L-Ascorbate oxidase, Cucumber can be used in baking processes and cereal‐based processes .

HY-W975966

CPDT	Keap1-Nrf2	Neurological Disease
CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro [2].

HY-E70375

Fructosyl-peptide oxidase (FPOX-CE) Fructosyl-peptide: oxygen oxidoreductase	Others	Others
Fructosyl-peptide oxidase (FPOX-CE) (Fructosyl-peptide: oxygen oxidoreductase) is an enzyme that catalyzes the oxidation of glycopeptides. Fructosyl-peptide oxidase (FPOX-CE) shows high activity against small molecule glycated peptides, but no activity is detected against the glycated hexapeptide standard fVHLTPE used in the study. Fructosyl-peptide oxidase (FPOX-CE) can be used in the study of diabetes monitoring .

HY-151974

*Xanthine oxidoreductase-IN-4*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-4 is an orally active *xanthine oxidoreductase* (XOR)** inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC₅₀ value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia .

HY-146297

*Xanthine oxidoreductase-IN-2*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-2 (Compound IVa) is a xanthine oxidoreductase (XOR) inhibitor with the IC₅₀ of 7.2 nM. Xanthine oxidoreductase-IN-2 shows hypouricemic effects in mice .

HY-149769A

CP-506 mesylate	Cytochrome P450	Cancer
CP-506 (compound 26) mesylate is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .

HY-N10191

Hydroaurantiogliocladin	Cytochrome P450	Metabolic Disease
Hydroaurantiogliocladin is a quinol. Hydroaurantiogliocladin can be used as substrate for the quinol-cytochrome c oxidoreductase activity (beef heart enzyme) .

HY-146296

*Xanthine oxidoreductase-IN-1*	Xanthine Oxidase	Metabolic Disease
The compound is a xanthine oxidoreductase (XOR) inhibitor with high inhibitory concentration, and the value of ic₅₀ is 7.0 nm.

HY-N14897

Pterulone	Quinone Reductase	Cancer
Pterulone is a coenzyme I: Coenzyme Q oxidoreductase inhibitor found in fungus Pterula SP.82168 .

HY-169842

NSC 645827	Quinone Reductase	Cancer
NSC 645827 is an inhibitor for *NAD(P)H: quinone oxidoreductase* 1 (NQO1) with an IC₅₀** of 0.7 μM .

HY-14669

Niraxostat Y-700; Piraxostat	Xanthine Oxidase	Metabolic Disease
Niraxostat (Y-700; Piraxostat) is an orally active xanthine oxidoreductase (XOR) inhibitor used in the study of hyperuricemia and other diseases in which XOR may be involved .

HY-159118

PC-Qz1	Bacterial	Infection
PC-Qz1 is a mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor with an IC₅₀ of 470 nM. PC-Qz1 has antibacterial activity .

HY-119815

Tenonitrozole	Bacterial	Infection
Tenonitrozole exhibits antibacterial activity through inhibition of pyruvate-ferredoxin oxidoreductase (PFOR). Tenonitrozole inhibits H. pylori and C. jejuni with MICs of 0.7 μM and 5.9 μM .

Cat. No.	Product Name	Type

HY-15924

Thiazolyl Blue 180+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dyes
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-DY1086

Thiazolyl Blue (solution)

MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)

Fluorescent Dyes

Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .
Solvent and concentration: PBS: 5 mg/mL

HY-D3209

NIR-ASM

Fluorescent Dyes

NIR-ASM is a near-infrared fluorescent probe that can cross cell membranes and be activated by NQO1. NIR-ASM can distinguish NQO1-expressing cancer cells from normal cells via fluorescence microscopy and flow cytometry. NIR-ASM generates near-infrared fluorescence with a high signal-to-noise ratio in tumor models with NQO1 activity, enabling the detection of endogenous NQO1 activity in vivo. NIR-ASM is applicable to the research of lung cancer and breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0645

Dicoumarol 10+ Cited Publications Dicumarol	Melilotus officinalis (L.) Pall. Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Quinone Reductase PDHK
Dicoumarol is an inhibitor of both *NAD(P)H:quinone oxidoreductase* 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-114936

Piericidin A 5 Publications Verification AR-054	Infection Microorganisms Neurological Disease Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Bacterial ADC Payload Antibiotic Mitochondrial Metabolism
Piericidin A (AR-054) is a natural mitochondrial *NADH-ubiquinone oxidoreductase* (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing** inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

HY-135024

Phenylacetyl CoA Phenylacetyl Coenzyme A	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica .

HY-N5018

Nepodin Musizin	Rumex crispus Linn. Infection Structural Classification Classification of Application Fields Polygonaceae Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields Source Classification	Parasite AMPK
Nepodin (Musizin) is a *quinone oxidoreductase* (PfNDH2)** inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-W016628

L-Gulono-1,4-lactone L-Gulonolactone	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-129278

Lunarine	Alkaloids Lunaria annua L. Other Alkaloids Plants Brassicaceae Source Classification	Parasite
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-N10191

Hydroaurantiogliocladin	Microorganisms Classification of Application Fields Phenols Polyphenols Metabolic Disease Disease Research Fields Source Classification	Cytochrome P450
Hydroaurantiogliocladin is a quinol. Hydroaurantiogliocladin can be used as substrate for the quinol-cytochrome c oxidoreductase activity (beef heart enzyme) .

HY-N14897

Pterulone	Microorganisms Antibiotics Other Antibiotics Source Classification	Quinone Reductase
Pterulone is a coenzyme I: Coenzyme Q oxidoreductase inhibitor found in fungus Pterula SP.82168 .

HY-135024A

Phenylacetyl CoA lithium Phenylacetyl coenzyme A lithium; S-Benzeneacetate-CoA lithium; S-Benzeneacetate-coenzyme A lithium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phenylacetyl CoA lithium (Phenylacetyl Coenzyme A lithium) is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica .

HY-N14947

Pterulinic acid	Microorganisms Antibiotics Other Antibiotics Source Classification	Quinone Reductase
Pterulinic acid is a coenzyme I: Coenzyme Q oxidoreductase inhibitor. he IC₅₀ (μg/mL) L1210 and HL60 of Pterulinic acid to mammalian cell lines are 50 and 20 respectively. HeLaS3 25; BHK is 100 .

HY-146036

NADH-IN-1	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NADH-IN-1 has NADH:ubiquinone oxidoreductase inhibitory activity with an IC₅₀ value of 27 μM. NADH-IN-1 can effectively stimulate glucose uptake in vitro. NADH-IN-1 is readily metabolised by the liver. NADH-IN-1 can be used for researching diabetes .

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Rumex crispus Linn. Polygonaceae Phenols Polyphenols Rumex japonicus Houtt. Plants Source Classification	Reference Standards Parasite AMPK
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N13110

23-Aldehyde-16-O-angeloybarringtogenol C	Triterpenes Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Others
23-Aldehyde-16-O-angeloybarringtogenol C (compound 7) is a tea seed saponin, an acid hydrolysis product obtained by oxidative alkaline degradation. Tea seed saponins have potential quinine oxidoreductase inducing activity .

Cat. No.	Product Name	Chemical Structure

HY-N0645S

Dicoumarol-d8
Dicoumarol-d₈ (Dicumarol-d₈) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-14874S

Topiroxostat-d4
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC₅₀ value of 5.3 nM and a K_i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment .

HY-W768934

L-Gulono-1,4-lactone-13C6
L-Gulono-1,4-lactone- ¹³C₆ (L-Gulonolactone- ¹³C₆) is the ¹³C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

HY-W012927S

4-Hydroxy-5-methylfuran-3(2H)-one-d3
4-Hydroxy-5-methylfuran-3(2H)-one-d₃ is deuterated labeled 4-Hydroxy-5-methylfuran-3(2H)-one (HY-W012927). 4-Hydroxy-5-methylfuran-3(2H)-one (Chicory furaneol) can be used to assay oxidoreductase activity. 4-Hydroxy-5-methylfuran-3(2H)-one is a kind of biological materials or organic compounds that are widely used in life science research .

Cat. No.	Product Name		Classification

HY-169203

Antifungal agent 119		Alkynes
Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions. .

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