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Isobutyl-deoxynyboquinone  (Synonyms: IB-DNQ)

Cat. No.: HY-125027 Purity: 99.70%
COA Handling Instructions

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer.

For research use only. We do not sell to patients.

Isobutyl-deoxynyboquinone Chemical Structure

Isobutyl-deoxynyboquinone Chemical Structure

CAS No. : 1430798-22-3

Size Price Stock Quantity
5 mg USD 580 In-stock
10 mg USD 980 In-stock
25 mg USD 1900 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer[1].

In Vitro

Isobutyl-deoxynyboquinone (0.01~100 μM; OSCC cells) demonstrates greater cytotoxic potency against SCCF1 and SCCF2 cell lines, and less against the SCCF3 cell line. Isobutyl-deoxynyboquinone (0.1~3 μM; 60 minutes; SCCF1 cells) induces cytotoxicity in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isobutyl-deoxynyboquinone (0.5~2 mg/kg; i.v.; 20 hours) achieves average peak plasma concentration levels. Isobutyl-deoxynyboquinone (1 mg/kg; p.o.; 4 hours) achieves peak plasma concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cats
Dosage: 0.5~2 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Achieved average peak plasma concentration levels.
Animal Model: Cats
Dosage: 1 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Achieved peak plasma concentration.
Molecular Weight

326.35

Formula

C18H18N2O4

CAS No.
Appearance

Solid

Color

Brown to red

SMILES

O=C1N(CC(C)C)C2=C(C(C(C(C)=CC(N3)=O)=C3C2=O)=O)C(C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (30.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0642 mL 15.3210 mL 30.6419 mL
5 mM 0.6128 mL 3.0642 mL 6.1284 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.70%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0642 mL 15.3210 mL 30.6419 mL 76.6049 mL
5 mM 0.6128 mL 3.0642 mL 6.1284 mL 15.3210 mL
10 mM 0.3064 mL 1.5321 mL 3.0642 mL 7.6605 mL
15 mM 0.2043 mL 1.0214 mL 2.0428 mL 5.1070 mL
20 mM 0.1532 mL 0.7660 mL 1.5321 mL 3.8302 mL
25 mM 0.1226 mL 0.6128 mL 1.2257 mL 3.0642 mL
30 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5535 mL
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Isobutyl-deoxynyboquinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Isobutyl-deoxynyboquinone
Cat. No.:
HY-125027
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