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Isobutyl-deoxynyboquinone (Synonyms: IB-DNQ)

Cat. No.: HY-125027
Handling Instructions

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer.

For research use only. We do not sell to patients.

Isobutyl-deoxynyboquinone Chemical Structure

Isobutyl-deoxynyboquinone Chemical Structure

CAS No. : 1430798-22-3

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Description

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer[1].

In Vitro

Isobutyl-deoxynyboquinone (0.01~100 μM; OSCC cells) demonstrates greater cytotoxic potency against SCCF1 and SCCF2 cell lines, and less against the SCCF3 cell line. Isobutyl-deoxynyboquinone (0.1~3 μM; 60 minutes; SCCF1 cells) induces cytotoxicity in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isobutyl-deoxynyboquinone (0.5~2 mg/kg; i.v.; 20 hours) achieves average peak plasma concentration levels. Isobutyl-deoxynyboquinone (1 mg/kg; p.o.; 4 hours) achieves peak plasma concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cats
Dosage: 0.5~2 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Achieved average peak plasma concentration levels.
Animal Model: Cats
Dosage: 1 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Achieved peak plasma concentration.
Molecular Weight

326.35

Formula

C₁₈H₁₈N₂O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Isobutyl-deoxynyboquinone
Cat. No.:
HY-125027
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