Tubulin inhibitor 14
Based on 1 Customer Validation
Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features.
For research use only. We do not sell to patients.
- Purity: 95.52%
- CAS No.: 2767446-34-2
- Formula: C15H9F2NO
- Molecular Weight:257.23
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 1.0 μM (NQO2)[1].
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.27 μM
Compound: 4
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
|
[PMID: 35290041] |
| A549 | IC50 |
0.44 μM
Compound: 4
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
|
[PMID: 35290041] |
| HCT-116 | IC50 |
0.13 μM
Compound: 4
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
|
[PMID: 35290041] |
| HCT-116 | IC50 |
0.13 μM
Compound: 4
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
|
[PMID: 35290041] |
| HepG2 | IC50 |
0.86 μM
Compound: 4
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
|
[PMID: 35290041] |
| HepG2 | IC50 |
1.44 μM
Compound: 4
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
|
[PMID: 35290041] |
| MCF7 | IC50 |
0.41 μM
Compound: 4
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
|
[PMID: 35290041] |
| MCF7 | IC50 |
0.5 μM
Compound: 4
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
|
[PMID: 35290041] |
| MDA-MB-231 | IC50 |
0.07 μM
Compound: 4
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
|
[PMID: 35290041] |
| MDA-MB-231 | IC50 |
0.09 μM
Compound: 4
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
|
[PMID: 35290041] |
| SNU-423 | IC50 |
0.25 μM
Compound: 4
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Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 96 hrs by Sulforhodamine B assay
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[PMID: 35290041] |
| SNU-423 | IC50 |
0.36 μM
Compound: 4
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Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
Antiproliferative activity against human SNU-423 cells assessed as inhibition of cell proliferation incubated for 24 hrs followed by 72 hrs of compound-free incubation by Sulforhodamine B assay
|
[PMID: 35290041] |
In Vitro
Tubulin inhibitor 14 (compound 4) (0-20 μM, 96 h) inhibits cancer cells proliferation [1].
Tubulin inhibitor 14 (1-5 μM, 24 or 48 h) causes G2/M cell cycle arrest[1].
Tubulin inhibitor 14 (0.5-1 μM, 24 h) induces SNU423 cell apoptosis[1].
Tubulin inhibitor 14 (0.5-1 μM, 24 h) disrupts the cytoskeleton network in endothelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, HepG2, SNU423, A549, HCT116
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Concentration:0 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, and 20 μM
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Incubation Time:96 h
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Result:Inhibited cell proliferation with IC50 values of 0.41 μM (MCF-7) , 0.07 μM (MDA-MB-231), 1.44 μM (HepG2), 0.25 μM (SNU423), 0.27 μM (A549), and 0.13 μM (HCT116).
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Cell Line:HepG2 cells
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Concentration:1, 2, 5 μM
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Incubation Time:24 h, 48 h
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Result:Caused G2/M cell cycle arrest.
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Cell Line:SNU423 cells
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Concentration:0.5, 1 μM
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Incubation Time:24 h
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Result:Induced SNU423 cell apoptosis.
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Cell Line:HUVECs
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Concentration:0.5, 1 μM
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Incubation Time:24 h
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Result:Disrupted the cytoskeleton network in endothelial cells.
Chemical Information
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CAS No. 2767446-34-2
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Appearance Solid
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Molecular Weight 257.23
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Formula C15H9F2NO
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Color White to off-white
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SMILES
O=C1NC(C2=CC=CC(F)=C2)=CC3=C1C=CC(F)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 5 mg/mL (19.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8876 mL | 19.4379 mL | 38.8757 mL | 97.1893 mL |
| 5 mM | 0.7775 mL | 3.8876 mL | 7.7751 mL | 19.4379 mL | |
| 10 mM | 0.3888 mL | 1.9438 mL | 3.8876 mL | 9.7189 mL | |
| 15 mM | 0.2592 mL | 1.2959 mL | 2.5917 mL | 6.4793 mL |
Tubulin inhibitor 14 Related Classifications
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