2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. Tubulin inhibitor 14

Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features.

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Tubulin inhibitor 14 Chemical Structure

Tubulin inhibitor 14 Chemical Structure

CAS No. : 2767446-34-2

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Tubulin inhibitor 14 Related Antibodies

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Description

Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features[1].

IC50 & Target

IC50: 1.0 μM (NQO2)[1].
In Vitro

Tubulin inhibitor 14 (compound 4) (0-20 μM, 96 h) inhibits cancer cells proliferation [1].
Tubulin inhibitor 14 (1-5 μM, 24 or 48 h) causes G2/M cell cycle arrest[1].
Tubulin inhibitor 14 (0.5-1 μM, 24 h) induces SNU423 cell apoptosis[1].
Tubulin inhibitor 14 (0.5-1 μM, 24 h) disrupts the cytoskeleton network in endothelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 14 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HepG2, SNU423, A549, HCT116
Concentration: 0 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, and 20 μM
Incubation Time: 96 h
Result: Inhibited cell proliferation with IC50 values of 0.41 μM (MCF-7) , 0.07 μM (MDA-MB-231), 1.44 μM (HepG2), 0.25 μM (SNU423), 0.27 μM (A549), and 0.13 μM (HCT116).

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 1, 2, 5 μM
Incubation Time: 24 h, 48 h
Result: Caused G2/M cell cycle arrest.

Apoptosis Analysis[1]

Cell Line: SNU423 cells
Concentration: 0.5, 1 μM
Incubation Time: 24 h
Result: Induced SNU423 cell apoptosis.

Immunofluorescence[1]

Cell Line: HUVECs
Concentration: 0.5, 1 μM
Incubation Time: 24 h
Result: Disrupted the cytoskeleton network in endothelial cells.
Molecular Weight

257.23

Formula

C15H9F2NO
CAS No.
SMILES

O=C1NC(C2=CC=CC(F)=C2)=CC3=C1C=CC(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 142767446-34-2Tubulin inhibitor14Tubulin inhibitor-14ApoptosisMicrotubule/TubulinHepG2SNU423 cellsLow cytotoxicityEndothelial cellTumor-selectivityAntiangiogenicVascular disruptingInhibitorinhibitorinhibit

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