2767446-34-2
Chemical Structure
Tubulin inhibitor 14
- CAS No.: 2767446-34-2
- Formula:C15H9F2NO
- Molecular Weight:257.23
IUPAC Name: 6-fluoro-3-(3-fluorophenyl)isoquinolin-1(2H)-one
InChIKey: ALUOVSMIKCVEQC-UHFFFAOYSA-N
SMILES: O=C1NC(C2=CC=CC(F)=C2)=CC3=C1C=CC(F)=C3
Biological Activity: Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features[1].
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Tubulin inhibitor 14 | Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features. | |||||||||||||||||||||
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Keywords
