Cat. No.: HY-N5018

Nepodin

(Synonyms: Musizin)

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Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiabetic and antimalarial activities.

For research use only. We do not sell to patients.

Purity: 97.46%
CAS No.: 3785-24-8
Formula: C₁₃H₁₂O₃
Molecular Weight:216.23

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Nepodin Chemical Structure

CAS No.: 3785-24-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus^[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK^[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

IC₅₀ & Target

Plasmodium

All Parasite Isoforms :

All AMPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	31 μg/mL Compound: Nepodin	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 2778455]
HT-29	ED₅₀	36.7 μg/mL Compound: Nepodin	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 2778455]

In Vitro

Nepodin (Musizin) exhibits significant IC₅₀ values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/KsJ-db/db mice^[2]
Dosage:

2 mg/kg; 10 mg/kg
Administration:

Orally administration; 2-10 mg/kg; 4 weeks
Result:

Had antihyperglycemic potential and improved insulin resistance.

Chemical Information

CAS No. 3785-24-8
Appearance Solid
Molecular Weight 216.23
Formula C₁₃H₁₂O₃
Color White to yellow
SMILES

CC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O
Synonyms

Musizin
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (578.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6247 mL

23.1235 mL

46.2471 mL

5 mM

0.9249 mL

4.6247 mL

9.2494 mL

10 mM

0.4625 mL

2.3124 mL

4.6247 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36(4):430-5. [Content Brief]

[2]. Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.6247 mL	23.1235 mL	46.2471 mL	115.6176 mL
	5 mM	0.9249 mL	4.6247 mL	9.2494 mL	23.1235 mL
	10 mM	0.4625 mL	2.3124 mL	4.6247 mL	11.5618 mL
	15 mM	0.3083 mL	1.5416 mL	3.0831 mL	7.7078 mL
	20 mM	0.2312 mL	1.1562 mL	2.3124 mL	5.7809 mL
	25 mM	0.1850 mL	0.9249 mL	1.8499 mL	4.6247 mL
	30 mM	0.1542 mL	0.7708 mL	1.5416 mL	3.8539 mL
	40 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8904 mL
	50 mM	0.0925 mL	0.4625 mL	0.9249 mL	2.3124 mL
	60 mM	0.0771 mL	0.3854 mL	0.7708 mL	1.9270 mL
	80 mM	0.0578 mL	0.2890 mL	0.5781 mL	1.4452 mL
	100 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL

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Nepodin

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All Parasite Isoforms

All AMPK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Nepodin Related Classifications

HY-N5018 Related Classifications