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    PI3K/Akt/mTOR
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  3. Nepodin

Nepodin (Synonyms: Musizin)

Cat. No.: HY-N5018
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Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiabetic and antimalarial activities.

For research use only. We do not sell to patients.

Nepodin Chemical Structure

Nepodin Chemical Structure

CAS No. : 3785-24-8

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Description

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

In Vitro

Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].

In Vivo

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2].

Animal Model: C57BL/KsJ-db/db mice[2]
Dosage: 2 mg/kg; 10 mg/kg
Administration: Orally administration; 2-10 mg/kg; 4 weeks
Result: Had antihyperglycemic potential and improved insulin resistance.
Molecular Weight

216.23

Formula

C₁₃H₁₂O₃

CAS No.

3785-24-8

SMILES

CC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O

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Keywords:

NepodinMusizinParasiteAMPKAMP-activated protein kinaseInhibitorinhibitorinhibit

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