Formate dehydrogenase 

Formate dehydrogenase is a class of oxidoreductases widely distributed in bacteria, fungi, plants and animals. Formate dehydrogenase catalyzes the reversible conversion between formic acid and carbon dioxide, accompanied by redox reactions of the coenzyme NAD⁺/NADH or other electron carriers^[1][2].

Overexpression of formate dehydrogenase (1 g/L formate; 48-96 h) in S. cerevisiae FA enhances the tolerance of S. cerevisiae FA to 1 g/L formate, decomposes formate into CO₂, and simultaneously improves glucose utilization, cell density and cell viability^[1].
Overexpression of formate dehydrogenase under conditions of 4 g/L acetic acid and 48-96 h in S. cerevisiae FA enhances the acetic acid tolerance of S. cerevisiae FA. By converting CO₂ into formate and additionally producing ATP, it enables faster glucose utilization, higher ethanol yield, higher cell density, and stronger cell viability^[1].
Formate dehydrogenase enhances aluminum tolerance in tobacco^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9028-85-7

Solid

White to light yellow

[Formate dehydrogenase]

1.2.1.2

≥5 U/mg protein

One unit is defined as the amount of enzyme that will oxidation of 1 μmol of formate per min to CO2 at pH 7.6 and 37°C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Du C, et al. Formate Dehydrogenase Improves the Resistance to Formic Acid and Acetic Acid Simultaneously in Saccharomyces cerevisiae. Int J Mol Sci. 2022 Mar 21;23(6):3406.  [Content Brief]

  [2]. Xie Y, et al. The formate dehydrogenase enhances aluminum tolerance of tobacco. J Genet. 2023;102:50.  [Content Brief]