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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
95 Results for "
toxic metabolite
" in MedChemExpress (MCE) Product Catalog:
Products (95)
95 Results for "toxic metabolite" in MCE Product Catalog:
77
77 Publications Verification
Synonyms: GS 4071 hydrochloride; Ro 64-0802 hydrochloride; Oseltamivir carboxylate hydrochloride
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Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis .
37
37 Cited Publications
Cat. No.: HY-W008719
CAS No.: 36913-39-0
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MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .
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4
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Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning .
4
4 Cited Publications
Cat. No.: HY-B0876A
CAS No.: 56010-88-9
Synonyms: 4-Methylpyrazole hydrochloride
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Research Areas:
Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning .
3
3 Cited Publications
Cat. No.: HY-W028393
CAS No.: 392-12-1
3
3 Cited Publications
Synonyms: Pyocyanine; Sanazin; Sanasin
Category:
2
2 Cited Publications
Cat. No.: HY-114577
CAS No.: 1070409-31-2
Synonyms: Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine
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Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
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Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .
1
1 Cited Publications
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Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
Synonyms: SN-38G
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SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
Synonyms: Vinylcyclohexene diepoxide
Research Areas:
Neurological Disease Inflammation/Immunology Endocrinology Cancer
4-Vinylcyclohexene dioxide (4-Vinylcyclohexene diepoxide) is an orally active metabolite of 4-vinylcyclohexene. 4-Vinylcyclohexene dioxide induces Apoptosis, increases intracellular ROS, and activates the PI3K/Akt/mTOR pathway. 4-Vinylcyclohexene dioxide selectively damages small ovarian follicles, inhibits granulosa cell function, and disrupts the male reproductive system. 4-Vinylcyclohexene dioxide can be used in the study of premature ovarian insufficiency, reproductive toxicity, and related fertility disorders .
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6α-Hydroxy paclitaxel is one of the main metabolites of Paclitaxel (PTX) (HY-B0015), and it is generated by the liver cytochrome P450 enzyme CYP2C8. 6α-Hydroxy paclitaxel has bone marrow toxicity, but it can enhance the cytotoxicity of PTX against leukemia cells without causing cell toxicity. 6α-Hydroxy paclitaxel can be used in leukemia research .
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Human Gut Microbiota Metabolites other families Microorganisms Ketones, Aldehydes, Acids Marine natural products Metabolic Disease Plants Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W017464
CAS No.: 50700-49-7
Synonyms: N-Acetyl-4-benzoquinone Imine
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Cat. No.: HY-N11678
CAS No.: 131180-21-7
Synonyms: DON-3-β-D-glucoside; Deoxynivalenol 3-glucoside
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Synonyms: LRCL 3794
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Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .
Category:
Microorganisms Monophenols Coumarins Phenols Phenylpropanoids Disease Research Fields Cancer
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Cat. No.: HY-G0004
CAS No.: 37519-14-5
Synonyms: 3-Hydroxyacetaminophen
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Research Areas:
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
