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Results for "

3-17

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (3) 17β-HSD (6) 5 alpha Reductase (1) 5-HT Receptor (3) Aldose Reductase (1) Apoptosis (5) Bacterial (1) Bcr-Abl (3) Biochemical Assay Reagents (8) Cadherin (1) Calcium Channel (2) CD3 (1) Cytochrome P450 (3) Dopamine Receptor (3) Drug Intermediate (3) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (6) Ephrin Receptor (1) Estrogen Receptor/ERR (2) Ferroptosis (1) FGFR (1) HCV (1) HSV (1) Interleukin Related (2) Isotope-Labeled Compounds (12) Ligands for E3 Ligase (1) mAChR (1) mTOR (2) nAChR (1) Neurokinin Receptor (2) P-glycoprotein (1) P2Y Receptor (1) PD-1/PD-L1 (1) PGE synthase (1) Phosphodiesterase (PDE) (2) PI3K (2) Progesterone Receptor (1) PROTAC Linkers (1) PROTACs (2) Proteasome (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Ribosomal S6 Kinase (RSK) (1) Sec61 (1) Src (2) Steroid Sulfatase (1) Transmembrane Glycoprotein (2) Tyrosinase (1) VEGFR (2) Wee1 (2)
By Research Areas:	Cancer (26) Cardiovascular Disease (5) Endocrinology (8) Infection (4) Inflammation/Immunology (13) Metabolic Disease (9) Neurological Disease (8)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12318

IBMX Maximum Cited Publications 69 Publications Verification 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine	Phosphodiesterase (PDE)	Inflammation/Immunology
IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC₅₀s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.

HY-P99052

Tislelizumab 3 Publications Verification BGB-A317	PD-1/PD-L1	Inflammation/Immunology Cancer
Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma .

HY-101016

17-ODYA 1 Publications Verification	Cytochrome P450 Apoptosis	Cardiovascular Disease
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC₅₀<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes ^[3]. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16025

EOC317 1 Publications Verification ACTB-1003	FGFR VEGFR	Cancer
EOC317 (ACTB-1003) is an oral kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2.

HY-114464

11-Beta-hydroxyandrostenedione 4-Androsten-11β-ol-3,17-dione	Endogenous Metabolite 11β-HSD	Endocrinology
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .

HY-122113

PD173952 1 Publications Verification	Src Bcr-Abl Apoptosis Wee1	Cancer
PD173952 is a tyrosine kinases inhibitor with IC₅₀s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a K_i of 8.1 nM. PD173952 induces apoptosis .

HY-147414

Vamotinib PF-114	Bcr-Abl	Cancer
Vamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib shows anti-proliferative and anti-tumor activity. Vamotinib has the potential for the research of resistant philadelphia chromosome-positive (Ph+) leukemia. Vamotinib inhibits ABL series kinases with IC₅₀s of 0.49 nM (ABL), 0.78 nM (ABL ^T315I), 9.5 nM (ABL ^E255K), 2.0 nM (ABL ^F317I), 7.4 nM (ABL ^G250E), 1.0 nM (ABL ^H396P), 2.8 nM (ABL ^M351T), 12 nM (ABL ^Q252H), and 4.1 nM (ABL ^Y253F), respectively . Vamotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12763

GNE-317 2 Publications Verification	PI3K mTOR	Cancer
GNE-317 is a PI3K/mTOR inhibitor, is able to cross the blood-brain barrier (BBB).

HY-114464S1

11-Beta-hydroxyandrostenedione-d7 4-Androsten-11β-ol-3,17-dione-d₇	Endogenous Metabolite 11β-HSD	Others
11-Beta-hydroxyandrostenedione-d₇ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor

HY-B0708

β-Estradiol 17-acetate 1 Publications Verification 1,3,5(10)-Estratriene-3,17β-diol 17-acetate	Estrogen Receptor/ERR	Endocrinology
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice .

HY-146486

P2Y2R/GPR17 antagonist 1	P2Y Receptor	Inflammation/Immunology
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y₂R and GPR17 antagonist with IC₅₀ values of 3.17 µM and 1.67 µM against P2Y₂R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes .

HY-139615

Sec61-IN-1	Sec61	Cancer
Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].

HY-100658

Didesmethyl cariprazine	5-HT Receptor Dopamine Receptor	Neurological Disease
Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine (HY-14763). Didesmethyl cariprazine is a partial agonist at the D₂ and D₃ receptors, full agonist at the 5-HT_1A receptor, and antagonist at the human 5-HT_2B receptor (K_i: 1.41 nM (human D_2L), 0.056 nM (human D₃), 1.7 nM (human 5-HT_1A), 0.52 nM (human 5-HT_2B)). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons .

HY-160959

AN317	nAChR	Neurological Disease
AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with K_i of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP ⁺. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) .

HY-175256

RSK2-IN-5	Ribosomal S6 Kinase (RSK)	Cancer
RSK2-IN-5 (compoud C24) is a p90 ribosomal S6 kinase 2 (RSK2) inhibitor with a K_d of 317 nM. RSK2-IN-5 exhibits antitumor activity against breast cancer and melanoma cancer cells .

HY-W587733

17α,20β-Dihydroxy-4-pregnen-3-one 17,20β-P; 17,20β-DHP	Endogenous Metabolite	Endocrinology
17α,20β-Dihydroxy-4-pregnen-3-one (17,20β-P) is a maturation-inducing steroid .

HY-158412

BT317	Proteasome Apoptosis	Cancer
BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity .

HY-113302

*19-Hydroxyandrost-4-ene-3,17-dione*	Endogenous Metabolite	Others
19-Hydroxyandrost-4-ene-3,17-dione is a substrate for Corticotropin-lipotropin and Cytochrome P450 19A1.

HY-149049

Cajaninstilbene acid Cajanine	HCV	Infection Inflammation/Immunology
Cajaninstilbene acid is a potent HCV inhibitor with an IC₅₀ of 3.17 μM. Cajaninstilbene acid inhibits HCV replications via down-regulates a cellular protein chondroitin sulfate N-acetylgalactosaminyltransferase 1 .

HY-A0102

AMCA 4-(Aminomethyl)-1-cyclohexanecarboxylic acid	PROTAC Linkers	Cancer
AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker. AMCA can be used to synthesize the PROTAC molecule YB-3–17 (HY-170405) .

HY-170517

PKMYT1-IN-8	Wee1 Ephrin Receptor	Cancer
PKMYT1-IN-8 (Compound 137) is the inhibitor for PKMYT1 with an IC₅₀ of 9 nM. PKMYT1-IN-8 inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2with IC₅₀s of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. PKMYT1-IN-8 inhibits the proliferation of cancer cell OVCAR3 with GI₅₀ of 2.02 μM .

HY-12318R

IBMX (Standard) 3-Isobutyl-1-methylxanthine (Standard); Isobutylmethylxanthine (Standard)	Reference Standards Phosphodiesterase (PDE)	Inflammation/Immunology
IBMX (Standard) is the analytical standard of IBMX. This product is intended for research and analytical applications. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.

HY-170405

YB-3–17	PROTACs mTOR	Cancer
YB-3-17 is a bifunctional molecule, that inhibits mTOR (IC₅₀=0.22 nM) or degrades G1 to S phase transition 1 gene (GSPT1, DC₅₀=5 nM) in a PROTAC mechanism. YB-3-17 exhibits antiproliferative activity in multi glioblastoma cell lines with IC₅₀ of nanomolare levels. YB-3-17 exhibits antitumor efficacy in mouse models . (Pink: ligand for target protein (HY-170407); Black: linker (HY-A0102); Blue: ligand for E3 ligase Cereblon (HY-14658))

HY-132723AS

17β-Estradiol-3-β-D-glucuronide-d3 sodium	Isotope-Labeled Compounds	Others
17β-Estradiol-3-β-D-glucuronide-d₃ (sodium) is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-P2743

Choline oxidase	Biochemical Assay Reagents	Others
Choline oxidase (EC 1.1.3.17) catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production .

HY-P990730

Cabotamig ARB202	CD3 Cadherin	Cancer
Cabotamig is a humanized bispecific T-cell engager antibody targeting *CDH17/CD3*. Cabotamig is generated from anti-CDH17 monoclonal ARB102 by linking a CD3-binding scFv in the format of IgG4-scFv. Cabotamig can be used for the research of cancer, such as gastric cancer and colon cancers .

HY-113040A

(17R,18S)-Epoxyeicosatetraenoic acid 17(R),18(S)-EETeTr	Calcium Channel	Cardiovascular Disease
(17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia .

HY-108952

17,17-(Ethylenedioxy)androst-4-en-3-one	5 alpha Reductase	Endocrinology
17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)androst-4-en-3-one can inhibit the reductase activity and inhibit the bond of a receptor protein and 5α-DHT .

HY-132723S

17β-Estradiol-3-β-D-glucuronide-d3	Isotope-Labeled Compounds	Others
17β-Estradiol-3-β-D-glucuronide-d₃ is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-103394

TC HSD 21	17β-HSD	Cancer
TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC₅₀ of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors .

HY-147638

MONIRO-1	Calcium Channel	Neurological Disease
MONIRO-1 is a T-type and N-type calcium channel blocker with IC₅₀ values of 34, 3.3, 1.7 and 7.2 µM against hCa_v2.2, hCa_v3.1, hCa_v3.2 and hCa_v3.3, respectively. MONIRO-1 has low activity against L-type calcium channels. MONIRO-1 can be used for the study of pain and epilepsy .

HY-P990276

Anti-Mouse CD317/BST2 Antibody (927)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse CD317/BST2 Antibody (927) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse *CD317/BST2. Anti-Mouse CD317/BST2* Antibody (927) can deplete plasmacytoid dendritic cells (pDC). Anti-Mouse CD317/BST2 Antibody (927) can be used for the researches of cancer, infection, inflammation and immunology, such as head and neck squamous cell carcinoma (HNSCC), murine cytomegalovirus (MCMV) infection and asthma .

HY-112608

CHMFL-PI3KD-317	PI3K	Cancer
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC₅₀, 62.6 nM), PI3Kβ (IC₅₀, 284 nM), PI3Kγ (IC₅₀, 202.7 nM), PIK3C2A (IC₅₀, >10000 nM), PIK3C2B (IC₅₀, 882.3 nM), VPS34 (IC₅₀, 1801.7 nM), PI4KIIIA (IC₅₀, 574.1 nM) and PI4KIIIB (IC₅₀, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC₅₀ of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells .

HY-174867

AY-4	PROTACs Ferroptosis	Cancer
AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (K_d = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe ²⁺) and ferric (Fe ³⁺) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871); Blue: E3 ligand Pomalidomide (HY-10984); Black: Linker, Pomalidomide-PEG3-acid (HY-174872)) .

HY-136092

*Androsta-1,4,6-triene-3,17-dione*	Cytochrome P450	Neurological Disease Endocrinology
Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a K_i of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory .

HY-113263S

17a-Hydroxypregnenolone-d3 17-OHP5-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
17a-Hydroxypregnenolone-d₃ (17-OHP5-d₃) is the deuterium labeled 17a-Hydroxypregnenolone (HY-113263). 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-118382

SCH-451659 STX1383	17β-HSD	Cancer
SCH-451659 (STX1383) is an orally active, selective 17β-HSD3 inhibitor with an IC₅₀ of 2.4 nM against h17β-HSD3. SCH-451659 selectively blocks the conversion of androstenedione to testosterone. SCH-451659 reduces testosterone levels in mice. SCH-451659 exhibits anticancer activity against androstenedione-dependent prostate tumors .

HY-P991283

AMG-317	Interleukin Related	Inflammation/Immunology
AMG 317 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). AMG 317 can be used in research related to asthma .

HY-114464S

11-Beta-hydroxyandrostenedione-d4 4-Androsten-11β-ol-3,17-dione-d₄	Isotope-Labeled Compounds Endogenous Metabolite 11β-HSD	Endocrinology
11-Beta-hydroxyandrostenedione-d₄ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor .

HY-146832S

*1,3-17:0 DG-d5*	Isotope-Labeled Compounds	Others
1,3-17:0 DG-d₅ is deuterium labeled 1,3-17:0 DG.

HY-W664824

Desalkylquazepam N-Desmethylquazepam	Drug Intermediate mAChR	Neurological Disease
Desalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines . Desalkylquazepam is a mAChR modulator (EC₅₀ = 0.317 µM) .

HY-P991429

THR-317	VEGFR	Metabolic Disease
THR-317 is a human monoclonal antibody (mAb) targeting PLGF. THR-317 can be used in Diabetic retinopathy research .

HY-19429A

SLV-317	Neurokinin Receptor	Neurological Disease
SLV-317 is an antagonist of the neurokinin-1 receptor with oral activity. SLV-317 can effective antagonist of substance P-induced effects .

HY-16906

T338C Src-IN-2	Src	Cancer
T338C Src-IN-2 is a mutant c-Src kinase inhibitor, with an IC₅₀ of 317 nM against T338C c-Src, 57 nM against T338C/V323A c-Src, and 19 nM against T338C/V323S c-Src. T338C Src-IN-2 inhibits the kinase activity of endogenous cysteine gatekeeper MOK. T338C Src-IN-2 reduces global phosphotyrosine levels in v-Src-ES1-transformed NIH-3T3 cells .

HY-167577

3,17β-O-Bis(methoxymethyl)estradiol	Biochemical Assay Reagents
3,17β-O-Bis(methoxymethyl)estradiol is a kind of biochemical reagent.

HY-19429

*SLV-317* free base**	Neurokinin Receptor	Metabolic Disease
SLV-317 (free base) is an antagonist of the neurokinin-1 receptor with oral activity. SLV-317 (free base) can effective antagonist of substance P-induced effects .

HY-146626S

*1,3,5(10)-Estratriene-17α-ethyl-3,17β-diol 3-methyl ether-d5*	Isotope-Labeled Compounds	Cancer
1,3,5(10)-Estratriene-17α-ethyl-3,17β-diol 3-methyl ether-d₅ is the deuterium labeled 1,3,5(10)-Estratriene-17α-ethyl-3,17β-diol 3-methyl ether .

HY-E70635

ABL1 F317I Recombinant Human Active Protein Kinase	Bcr-Abl	Cancer
The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs Imatinib Mesylate (HY-50946) binding capacity, thus contributing to Imatinib Mesylate resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML). ABL1 F317I Recombinant Human Active Protein Kinase is a recombinant ABL1 F317I protein that can be used to study ABL1 F317I-related functions .

HY-W140270R

*(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol (Standard)*	Reference Standards
(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol (Standard) is the analytical standard of (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol. This product is intended for research and analytical applications.

HY-W742491

Betamethasone 21-Acetate-d3 17-Propionate	Isotope-Labeled Compounds	Others
Betamethasone 21-Acetate-d₃ 17-Propionate is the deuterium labeled Betamethasone Dipropionate EP Impurity D (HY-148661).

Cat. No.	Product Name

HY-L918

Molecular Glue-like Compound Library

317 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Cat. No.	Product Name	Target	Research Area

HY-P4965

*Tau Peptide (306-317)*	Peptides	Others
Tau Peptide (306-317) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99052

Tislelizumab 3 Publications Verification BGB-A317	PD-1/PD-L1	Inflammation/Immunology Cancer
Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma .

HY-P990730

Cabotamig ARB202	CD3 Cadherin	Cancer
Cabotamig is a humanized bispecific T-cell engager antibody targeting *CDH17/CD3*. Cabotamig is generated from anti-CDH17 monoclonal ARB102 by linking a CD3-binding scFv in the format of IgG4-scFv. Cabotamig can be used for the research of cancer, such as gastric cancer and colon cancers .

HY-P990276

Anti-Mouse CD317/BST2 Antibody (927)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse CD317/BST2 Antibody (927) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse *CD317/BST2. Anti-Mouse CD317/BST2* Antibody (927) can deplete plasmacytoid dendritic cells (pDC). Anti-Mouse CD317/BST2 Antibody (927) can be used for the researches of cancer, infection, inflammation and immunology, such as head and neck squamous cell carcinoma (HNSCC), murine cytomegalovirus (MCMV) infection and asthma .

HY-P990345

Anti-BST2/CD317 Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-BST2/CD317 Antibody is a CHO-expressed human antibody that targets *BST2/CD317. The Anti-BST2/CD317 Antibody is equipped with a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti*-BST2/CD317 Antibody can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991283

AMG-317	Interleukin Related	Inflammation/Immunology
AMG 317 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). AMG 317 can be used in research related to asthma .

HY-P991429

THR-317	VEGFR	Metabolic Disease
THR-317 is a human monoclonal antibody (mAb) targeting PLGF. THR-317 can be used in Diabetic retinopathy research .

HY-P991885

Anti-CD317 Antibody (HM1.24 )	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-CD317 Antibody (HM1.24 ) is an antibody against human *BST2/CD317*. Recommend Isotype Controls:?Rat IgG2b kappa, Isotype Control (HY-P990682).

HY-P992419

MW11-h317

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114464

11-Beta-hydroxyandrostenedione 4-Androsten-11β-ol-3,17-dione	Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite 11β-HSD
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .

HY-B0708

β-Estradiol 17-acetate 1 Publications Verification 1,3,5(10)-Estratriene-3,17β-diol 17-acetate	Structural Classification Monophenols Animals Classification of Application Fields Phenols Disease Research Fields Endocrinology Steroids Source Classification	Estrogen Receptor/ERR
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice .

HY-113302

*19-Hydroxyandrost-4-ene-3,17-dione*	Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
19-Hydroxyandrost-4-ene-3,17-dione is a substrate for Corticotropin-lipotropin and Cytochrome P450 19A1.

HY-149049

Cajaninstilbene acid Cajanine	Simple Phenylpropanols Leguminosae Phenylpropanoids Plants Cajanus cajan (L.) Millsp. Source Classification	HCV
Cajaninstilbene acid is a potent HCV inhibitor with an IC₅₀ of 3.17 μM. Cajaninstilbene acid inhibits HCV replications via down-regulates a cellular protein chondroitin sulfate N-acetylgalactosaminyltransferase 1 .

HY-N9774

*(3β,20S)-Pregn-5-ene-3,17,20-triol*	Structural Classification Asclepiadaceae Plants Periploca sepium Bunge Steroids Source Classification	Others
(3β,20S)-Pregn-5-ene-3,17,20-triol is a natural product .

HY-N10286

Chetoseminudin B	Alkaloids Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Indole Alkaloids Source Classification	Tyrosinase
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .

HY-N13290

*10-Chloroestra-1,4-diene-3,17-dione* 10-CIEsra	Animals Steroids Source Classification	Estrogen Receptor/ERR
10-Chloroestra-1,4-diene-3,17-dione (10-CIEsra) is a derivative of estrogen receptor .

Species:	Human (4) Cynomolgus (2)
Tag:	His (8) Strep (1) Tag Free (1)
Source:	HEK293 (5) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704040

	KMO Protein, Human (His) dJ317G22.1; kmo; KMO_HUMAN; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase); Kynurenine 3 monooxygenase; Kynurenine 3-hydroxylase; Kynurenine 3-monooxygenase; RP1-317G22.1	Human	E. coli
	KMO Protein, Human (His) is the recombinant human-derived KMO protein, expressed by E. coli, with N-10*His tag.

HY-P700667

	BST2 Protein, Cynomolgus (HEK293, His) BST-2; HM1.24 antigen; CD317; BST2; NPC-A-7; PDCA-1; TETHERIN	Cynomolgus	HEK293
	The BST2 protein is an IFN-induced antiviral factor that inhibits mammalian enveloped viruses by tethering viral particles to infected cell membranes. BST2 acts as a physical tether connecting virions, limiting their release and spread. BST2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BST2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P704564

	*Delta-like protein 3/DLL3 Protein, Human (317a.a, HEK293, His)* Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3	Human	HEK293
	Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (317a.a, HEK293, His) is the recombinant human-derived Delta-like protein, expressed by HEK293, with C-His labeled tag.

HY-P704679

	IgG1 Protein, Human (C103S, M135Y, S137T, T139E, H316K, N317F, HEK293, His) Ig gamma-1 chain C region; IGHG1	Human	HEK293
	The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. IgG1 Protein, Human (C103S, M135Y, S137T, T139E, H316K, N317F, HEK293, His) is the recombinant human-derived IgG1 protein, expressed by HEK293, with C-His labeled tag.

HY-P704684

	FITC-Labeled IgG1 Protein, Human (C103S, M135Y, S137T, T139E, H316K, N317F, HEK293, His) Ig gamma-1 chain C region; IGHG1	Human	HEK293
	The IgG1 protein is the constant region of the immunoglobulin heavy chain and serves as a receptor during the recognition phase of humoral immunity. It triggers clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. FITC-Labeled IgG1 Protein, Human (C103S, M135Y, S137T, T139E, H316K, N317F, HEK293, His) is the recombinant human-derived FITC-Labeled IgG1 protein, expressed by HEK293, with C-His labeled tag.

HY-P700702

	*Fractalkine/CX3CL1 Protein, Cynomolgus (317a.a, HEK293, His)* Fractalkine; Neurotactin; Cx3cl1; Cx3c; Fkn; ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1	Cynomolgus	HEK293
	The Fractalkine/CX3CL1 protein is a member of the intercrine beta family and plays a key role in chemokines that are critical for intercellular communication and immune responses. In this family, Fractalkine/CX3CL1 may significantly regulate inflammatory processes and cellular interactions. Fractalkine/CX3CL1 Protein, Cynomolgus (317a.a, HEK293, His) is the recombinant cynomolgus-derived Fractalkine/CX3CL1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P701979

	kshB Protein, Mycobacterium tuberculosis hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis is the recombinant kshB protein, expressed by E. coli , with tag free.

HY-P701980

	kshB Protein, Mycobacterium tuberculosis (His) hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis (His) is the recombinant kshB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703426

	kshA Protein, Mycobacterium tuberculosis (His, Strep) 3-ketosteroid-9-alpha-monooxygenase, oxygenase component; 3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RO; kshA; Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); Oxidoreductase;	Others	E. coli
	kshA Protein, Mycobacterium tuberculosis (His, Strep) is the recombinant kshA, expressed by E. coli , with Strep, His labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-114464S1

11-Beta-hydroxyandrostenedione-d7
11-Beta-hydroxyandrostenedione-d₇ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor

HY-132723AS

17β-Estradiol-3-β-D-glucuronide-d3 sodium
17β-Estradiol-3-β-D-glucuronide-d₃ (sodium) is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-132723S

17β-Estradiol-3-β-D-glucuronide-d3
17β-Estradiol-3-β-D-glucuronide-d₃ is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-113263S

17a-Hydroxypregnenolone-d3
17a-Hydroxypregnenolone-d₃ (17-OHP5-d₃) is the deuterium labeled 17a-Hydroxypregnenolone (HY-113263). 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-114464S

11-Beta-hydroxyandrostenedione-d4
11-Beta-hydroxyandrostenedione-d₄ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor .

HY-146832S

*1,3-17:0 DG-d5*
1,3-17:0 DG-d₅ is deuterium labeled 1,3-17:0 DG.

HY-146626S

*1,3,5(10)-Estratriene-17α-ethyl-3,17β-diol 3-methyl ether-d5*
1,3,5(10)-Estratriene-17α-ethyl-3,17β-diol 3-methyl ether-d₅ is the deuterium labeled 1,3,5(10)-Estratriene-17α-ethyl-3,17β-diol 3-methyl ether .

HY-W742491

Betamethasone 21-Acetate-d3 17-Propionate
Betamethasone 21-Acetate-d₃ 17-Propionate is the deuterium labeled Betamethasone Dipropionate EP Impurity D (HY-148661).

HY-W740121

4-Methoxy-d3 17b-estradiol
4-Methoxy-d₃ 17b-estradiol is the deuterium labeled 4-Methoxyestradiol (HY-148296). 4-Methoxyestradiol is methoxylestradiol that induces oxidative DNA damage in human lung epithelial cells. 4-Methoxyestradiol also elevates ROS and SOD activities in H1355 cells .

HY-163253S

HSD17B13-IN-56-d3
HSD17B13-IN-56-D3 (Compound 169) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of ≤ 0.1 μM for estradiol. HSD17B13-IN-56-D3 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) .

HY-163263S

HSD17B13-IN-80-d3
HSD17B13-IN-80-d3 (179) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC₅₀ of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-163259S

HSD17B13-IN-62-d3
HSD17B13-IN-62-d3 (176) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC₅₀ of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-B0683S

Limaprost-d3
Limaprost-d₃ (17α,20-dimethyl-δ2-PGE1-d₃) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research .

HY-W742818

3-O-Benzyl 17b-Estradiol-d3 17-Acetate
3-O-Benzyl 17b-Estradiol-d₃ 17-Acetate is the deuterium labeled 3-O-Benzyl 17b-Estradiol 17-Acetate.

HY-W767663

17b-Hydroxy Exemestane-d3 17-O-b-D-Glucuronide
17b-Hydroxy Exemestane-d₃ 17-O-b-D-Glucuronide is the deuterium labeled 17b-Hydroxy Exemestane 17-O-b-D-Glucuronide.

HY-144947S

Beclomethasone-17-monopropionate-d3
Beclomethasone-17-monopropionate-d₃ is deuterium labeled Beclomethasone-17-monopropionate .

HY-100658S

Didesmethyl cariprazine-d8

Didesmethyl cariprazine-d₈ is the deuterium labeled Didesmethyl cariprazine (HY-100658). Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine (HY-14763). Didesmethyl cariprazine is a partial agonist at the D2 and D3 receptors, full agonist at the 5-HT1A receptor, and antagonist at the human 5-HT2B receptor (K_i: 1.41 nM (human D2L), 0.056 nM (human D3), 1.7 nM (human 5-HT1A), 0.52 nM (human 5-HT2B)). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons.

Host:	Mouse (2) Rabbit (5)
Reactivity:	Human (7) Rat (5) Mouse (3)
Application:	IHC-P (7) ICC/IF (3) IP (3) IHC-F (2) WB (5) FC (1) ELISA (1)
Isotype:	IgG (4) IgG1 (2) IgG, Kappa (1)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (5) Recombinant (4)
Modification:	Phosphorylated (1) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87896

	Phospho-Chk1 (Ser317) Antibody (YA7581)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Chk1 (Ser317) Antibody (YA7581) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-Chk1 (Ser317).

HY-P80738

	Lactate Dehydrogenase A Antibody (YA317) LDHA; LDH-M; LDH1; PIG19; GSD11; TRG5; Proliferation inducing gene 19	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
	Lactate Dehydrogenase A Antibody (YA317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P80738A

	Lactate Dehydrogenase A Antibody (YA317)(PBS only) LDHA; LDH-M; LDH1; PIG19; GSD11; TRG5; Proliferation inducing gene 19	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
	Lactate Dehydrogenase A Antibody (YA317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

HY-P83612

	BST2 Antibody (YA3357) Bone marrow stromal antigen 2; BST2; CD317; HM1.24 antigen; NPC A 7; Tetherin	WB, IHC-P, FC	Human
	BST2 Antibody (YA3357) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BST2.

HY-P88454

	HIST1H2BA Antibody (YA8138) bA317E16.3; H2BFU; STBP; TH2B; TSH2B; TSH2B.1	IHC-P	Human, Mouse, Rat
	HIST1H2BA Antibody (YA8138) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIST1H2BA.

HY-P88454A

	HIST1H2BA Antibody (YA8138)(PBS only) bA317E16.3; H2BFU; STBP; TH2B; TSH2B; TSH2B.1	IHC-P	Human, Mouse, Rat
	HIST1H2BA Antibody (YA8138) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIST1H2BA.

HY-P87145

	VSIG4 Antibody (YA6838) Complement receptor of the immunoglobulin superfamily antibody; CRIg antibody; Ig superfamily protein antibody; Protein Z39Ig antibody; UNQ317/PRO362 antibody; V set and immunoglobulin domain containing 4 antibody; V-set and immunoglobulin domain-containing protein 4 antibody; VSIG4 antibody; VSIG4_HUMAN antibody; Z39IG antibody;	WB, IHC-P	Human
	VSIG4 Antibody (YA6838) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VSIG4.