HIST1H2BA Antibody (YA8138)

Cat. No.: HY-P88454: Data Sheet User Guide for Antibodies
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HIST1H2BA Antibody (YA8138) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIST1H2BA.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

HIST1H2BA Antibody (YA8138) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIST1H2BA.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 14 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q96A08

Immunogen

Human recombinant protein fragment corresponding to amino acids 2-127 of human HIST1H2BA produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133)

Subcellular Localization：Nucleus,Chromosome

Expression：
Tissue_Specificity: Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells

Isoforms & Post-Translational Modification：Q96A08: 127 amino acids, molecular weight 14167 Da.

Subunit：The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers

Synonyms

bA317E16.3; H2BFU; STBP; TH2B; TSH2B; TSH2B.1

Documentation

User Guide for Antibodies (1077 KB)