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Cat. No.: HY-16906

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T338C Src-IN-2

고객리뷰

Based on 1 Customer Validation

T338C Src-IN-2 is a mutant c-Src kinase inhibitor, with an IC₅₀ of 317 nM against T338C c-Src, 57 nM against T338C/V323A c-Src, and 19 nM against T338C/V323S c-Src. T338C Src-IN-2 inhibits the kinase activity of endogenous cysteine gatekeeper MOK. T338C Src-IN-2 reduces global phosphotyrosine levels in v-Src-ES1-transformed NIH-3T3 cells.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.41%
CAS No.: 1351927-00-8
화학식: C₁₇H₁₈FN₅O
분자량:327.36

보관:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

T338C Src-IN-2 Chemical Structure

CAS No.: 1351927-00-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Src Isoforms :

In Vitro

T338C Src-IN-2 (Compound 13) (1 μM) potently inhibits immunoprecipitated MOK at a concentration of 1 μM, reducing kinase activity to near-background levels^[1].
T338C Src-IN-2 (0-10 μM; 1 h) selectively inhibits v-Src-ES1 (v-Src^I338C) in NIH-3T3 cells in a dose-dependent manner in vitro, and shows no activity against v-Src^I338T at concentrations up to 10 μM^[1].
T338C Src-IN-2 (10 min) exhibits enhanced potency against the double mutants c-Src-ES2^T338C/V323A and c-Src-ES3^T338C/V323S, with IC₅₀ values of 57 nM and 19 nM, respectively, representing 6-fold and 17-fold increases in activity compared to that against c-Src-ES1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

NIH-3T3 cells
Concentration:

0, 1.25, 2.5, 5, 10 μM
Incubation Time:

1 h
Result:

Inhibited v-Src-ES1 (v-SrcI338C) in NIH-3T3 cells, and showed no activity against v-SrcI338T at concentrations up to 10 μM.

Chemical Information

CAS No. 1351927-00-8
Appearance Solid
분자량 327.36
화학식 C₁₇H₁₈FN₅O
Color White to off-white
SMILES

NC1=C2C(N(C(C)C)N=C2CC3=CC(C(CF)=O)=CC=C3)=NC=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011;108(37):15046-15052. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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T338C Src-IN-2

Bioactive Compound Library Max

Bioactive Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Cysteine Targeted Covalent Library

MCE Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

All Src Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

T338C Src-IN-2

Bioactive Compound Library Max

Bioactive Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Cysteine Targeted Covalent Library

MCE Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

All Src Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

T338C Src-IN-2 Related Classifications

HY-16906 Related Classifications