T338C Src-IN-2
Based on 1 Customer Validation
T338C Src-IN-2 is a mutant c-Src kinase inhibitor, with an IC50 of 317 nM against T338C c-Src, 57 nM against T338C/V323A c-Src, and 19 nM against T338C/V323S c-Src. T338C Src-IN-2 inhibits the kinase activity of endogenous cysteine gatekeeper MOK. T338C Src-IN-2 reduces global phosphotyrosine levels in v-Src-ES1-transformed NIH-3T3 cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.41%
- No. CAS: 1351927-00-8
- Fòrmula: C17H18FN5O
- Peso molecular:327.36
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Actividad biológica
T338C Src-IN-2 (Compound 13) (1 μM) potently inhibits immunoprecipitated MOK at a concentration of 1 μM, reducing kinase activity to near-background levels[1].
T338C Src-IN-2 (0-10 μM; 1 h) selectively inhibits v-Src-ES1 (v-SrcI338C) in NIH-3T3 cells in a dose-dependent manner in vitro, and shows no activity against v-SrcI338T at concentrations up to 10 μM[1].
T338C Src-IN-2 (10 min) exhibits enhanced potency against the double mutants c-Src-ES2T338C/V323A and c-Src-ES3T338C/V323S, with IC50 values of 57 nM and 19 nM, respectively, representing 6-fold and 17-fold increases in activity compared to that against c-Src-ES1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH-3T3 cells
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Concentration:0, 1.25, 2.5, 5, 10 μM
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Incubation Time:1 h
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Result:Inhibited v-Src-ES1 (v-SrcI338C) in NIH-3T3 cells, and showed no activity against v-SrcI338T at concentrations up to 10 μM.
Chemical Information
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No. CAS 1351927-00-8
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Appearance Solid
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Peso molecular 327.36
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Fòrmula C17H18FN5O
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Color White to off-white
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SMILES
NC1=C2C(N(C(C)C)N=C2CC3=CC(C(CF)=O)=CC=C3)=NC=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T338C Src-IN-2 Related Classifications
HY-16906 Related Classifications
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