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  3. Androsta-1,4,6-triene-3,17-dione

Androsta-1,4,6-triene-3,17-dione 

Cat. No.: HY-136092
Handling Instructions

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory.

For research use only. We do not sell to patients.

Androsta-1,4,6-triene-3,17-dione Chemical Structure

Androsta-1,4,6-triene-3,17-dione Chemical Structure

CAS No. : 633-35-2

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Description

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].

IC50 & Target

Ki: 0.18 μM (aromatase)[1]

In Vivo

Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2].
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (220-250 g)[2]
Dosage: 25 mg/kg, 100 mg/kg
Administration: Subcutaneous injection
Result: Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus.
Molecular Weight

282.38

Formula

C₁₉H₂₂O₂

CAS No.

633-35-2

SMILES

C[[email protected]]1([[email protected]](CC2)([H])[[email protected]]3([H])C=CC4=CC(C=C[[email protected]]4(C)[[email protected]@]3([H])CC1)=O)C2=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Androsta-1,4,6-triene-3,17-dioneAromatasehippocampusHPestrogensynthetaseantifertilityspatialmemoryimpairmentInhibitorinhibitorinhibit

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Product Name:
Androsta-1,4,6-triene-3,17-dione
Cat. No.:
HY-136092
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