TC HSD 21
Based on 1 Customer Validation
TC HSD 21 is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) against related 17β-HSD isozymes, with an IC50 of 14 nM in HeLa cells. TC HSD 21 can be used in the research of prostate cancer.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 330203-01-5
- Formula: C17H12BrNO3S2
- Molecular Weight:422.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Covalent Screening Library
HY-L036
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Anti-Prostate Cancer Compound Library
HY-L124
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
All 17β-HSD Isoforms
More
Biological Activity
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17β-HSD3 14 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
14 nM
Compound: 1a
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Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry
Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry
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[PMID: 22512907] |
| HeLa | IC50 |
14 nM
Compound: 21
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Inhibition of human 17beta-HSD3 expressed in HeLa cells assessed as conversion of 4-androstene-3,17-dione to testosterone
Inhibition of human 17beta-HSD3 expressed in HeLa cells assessed as conversion of 4-androstene-3,17-dione to testosterone
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[PMID: 22137341] |
TC HSD 21 (Compound 21) potently inhibits 17β-HSD3 in HeLa cells expressing human 17β-HSD3, with an IC50 of 14 nM, and exhibits species-dependent potency against 17β-HSD3 in testicular homogenate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 330203-01-5
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Appearance Solid
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Molecular Weight 422.32
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Formula C17H12BrNO3S2
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Color Light yellow to yellow
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SMILES
O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C\C3=CC=C(O)C(Br)=C3)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 250 mg/mL (591.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3679 mL | 11.8394 mL | 23.6787 mL | 59.1968 mL |
| 5 mM | 0.4736 mL | 2.3679 mL | 4.7357 mL | 11.8394 mL | |
| 10 mM | 0.2368 mL | 1.1839 mL | 2.3679 mL | 5.9197 mL | |
| 15 mM | 0.1579 mL | 0.7893 mL | 1.5786 mL | 3.9465 mL | |
| 20 mM | 0.1184 mL | 0.5920 mL | 1.1839 mL | 2.9598 mL | |
| 25 mM | 0.0947 mL | 0.4736 mL | 0.9471 mL | 2.3679 mL | |
| 30 mM | 0.0789 mL | 0.3946 mL | 0.7893 mL | 1.9732 mL | |
| 40 mM | 0.0592 mL | 0.2960 mL | 0.5920 mL | 1.4799 mL | |
| 50 mM | 0.0474 mL | 0.2368 mL | 0.4736 mL | 1.1839 mL | |
| 60 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9866 mL | |
| 80 mM | 0.0296 mL | 0.1480 mL | 0.2960 mL | 0.7400 mL | |
| 100 mM | 0.0237 mL | 0.1184 mL | 0.2368 mL | 0.5920 mL |
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