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  4. TC HSD 21

TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors.

For research use only. We do not sell to patients.

TC HSD 21 Chemical Structure

TC HSD 21 Chemical Structure

CAS No. : 330203-01-5

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 154 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 230 In-stock
25 mg USD 460 In-stock
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Based on 1 publication(s) in Google Scholar

TC HSD 21 Related Antibodies

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Description

TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].

IC50 & Target

IC50: 14 nM (17β-HSD3)[1]
Molecular Weight

422.32

Formula

C17H12BrNO3S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C\C3=CC=C(O)C(Br)=C3)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (591.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3679 mL 11.8394 mL 23.6787 mL
5 mM 0.4736 mL 2.3679 mL 4.7357 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.14%

COA (248 KB) HNMR (275 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3679 mL 11.8394 mL 23.6787 mL 59.1968 mL
5 mM 0.4736 mL 2.3679 mL 4.7357 mL 11.8394 mL
10 mM 0.2368 mL 1.1839 mL 2.3679 mL 5.9197 mL
15 mM 0.1579 mL 0.7893 mL 1.5786 mL 3.9465 mL
20 mM 0.1184 mL 0.5920 mL 1.1839 mL 2.9598 mL
25 mM 0.0947 mL 0.4736 mL 0.9471 mL 2.3679 mL
30 mM 0.0789 mL 0.3946 mL 0.7893 mL 1.9732 mL
40 mM 0.0592 mL 0.2960 mL 0.5920 mL 1.4799 mL
50 mM 0.0474 mL 0.2368 mL 0.4736 mL 1.1839 mL
60 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9866 mL
80 mM 0.0296 mL 0.1480 mL 0.2960 mL 0.7400 mL
100 mM 0.0237 mL 0.1184 mL 0.2368 mL 0.5920 mL
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TC HSD 21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC HSD 21330203-01-5TC HSD21TC HSD-21OthersInhibitorinhibitorinhibit

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