2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sec61

Sec61

Sec61 complex, SecY, Sec61 channel

Sec61 is a heterotrimeric protein complex located on the endoplasmic reticulum membrane and belongs to the protein transporter family. Sec61 is mainly composed of Sec61α, Sec61β and Sec61γ. Sec61 is closely associated with signal recognition particles (SRP), SRP receptors, BiP, Sec62/Sec63 complex, TRAP, OST, etc. The main function of Sec61 is to assist the entry of nascent polypeptides into the endoplasmic reticulum during protein translation, participate in the transmembrane transport, membrane insertion and folding modification of proteins, and also play a role in the regulation of calcium ion homeostasis, as an endoplasmic reticulum calcium ion leakage channel to affect intracellular calcium signals. Specific Sec61 mutations can disrupt endoplasmic reticulum calcium balance and induce pancreatic β-cell apoptosis. Sec61 mutations interfere with the normal function of B cells. Abnormal expression of Sec61 is closely related to cell proliferation, invasion and drug resistance. Sec61 is closely related to a variety of diseases, including diabetes, immunodeficiency diseases (such as common variable immunodeficiency disease), kidney diseases (such as tubulointerstitial disease), and cancer. [1][2][3][4][5][6].

Sec61 Related Products (8):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139615
    Sec61-IN-1
    		Inhibitor 99.70%
    Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
    Sec61-IN-1
  • HY-139617
    Sec61-IN-3
    		Inhibitor 99.22%
    Sec61-IN-2 (A3) is a protein secretion inhibitor (extracted from patent WO2020176863).
    Sec61-IN-3
  • HY-139616
    Sec61-IN-2
    		Inhibitor 99.51%
    Sec61-IN-2 (A347) is a protein secretion inhibitor (extracted from patent WO2020176863).
    Sec61-IN-2
  • HY-176763
    KZR-261
    		Inhibitor
    KZR-261 is a Sec61 translocase inhibitor. KZR-261 binds directly to the Sec61 channel, thereby inhibiting the biosynthesis of certain Sec61 substrate proteins, including oncogenic factors. KZR-261 activates the endoplasmic reticulum stress response. KZR-261 exhibits broad in vitro anticancer activity. KZR-261 shows antitumor efficacy in mouse models of cancer. KZR-261 can be used for the research of multiple myeloma, colorectal cancer, small cell lung cancer, pancreatic cancer, prostate cancer, non-Hodgkin's lymphoma, and mantle cell lymphoma.
    KZR-261
  • HY-P3987A
    Cotransin TFA
    		Ligand
    Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research.
    Cotransin TFA
  • HY-182674
    VGD020
    		Inhibitor
    VGD020 is a highly potent and selective Sec61 translocon inhibitor. VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer.
    VGD020
  • HY-P10466A
    KZR-8445 TFA
    		Inhibitor
    KZR-8445 TFA, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 TFA binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 TFA inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 TFA inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 TFA blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 TFA can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection.
    KZR-8445 TFA
  • HY-P10466
    KZR-8445
    		Inhibitor
    KZR-8445, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection.
    KZR-8445