2. Membrane Transporter/Ion Channel
  3. Sec61
  4. Cotransin TFA

Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cotransin TFA

Cotransin TFA Chemical Structure

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Cotransin TFA Related Antibodies

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Description

Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research[1][2].

In Vitro

Cotransin TFA inhibits the biogenesis of a subset of secretory proteins and membrane proteins in a signal peptide-dependent manner[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cotransin TFA Related Antibodies
Molecular Weight

785.02 (free base)

Formula

C42H68N6O8·xC2HF3O2
Sequence

cyclo(Ala(NMe)-{D-Lactic acid}-Leu-Leu(NMe)-Leu-Phe(NMe)-Leu)
Sequence Shortening

cyclo(Ala(NMe)-{D-Lactic acid}-L-Leu(NMe)-L-Phe(NMe)-L)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cotransin TFA Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CotransinSec61Sec61 complex, SecY, Sec61 channelcancermembrane proteinssignal peptidecotranslational protein translocationSec61 transloconsecretory proteinsInhibitorinhibitorinhibit

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Cotransin TFA
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HY-P3987A
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