2484865-72-5
Chemical Structure
Sec61-IN-2
- CAS. Nr.: 2484865-72-5
- Formula:C22H19N5OS
- Molecular Weight:401.48
IUPAC Name: (E)-N-(4-(2-(3-methylpyridin-2-yl)vinyl)thiazol-2-yl)-1-(pyridin-4-ylmethyl)-1H-pyrrole-2-carboxamide
InChIKey: PWRJGWUGWDERBT-VOTSOKGWSA-N
SMILES: O=C(C1=CC=CN1CC2=CC=NC=C2)NC3=NC(/C=C/C4=NC=CC=C4C)=CS3
Biological Activity: Sec61-IN-2 is a Sec61 inhibitor. Sec61-IN-2 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC50 = 42 nM), while it has almost no inhibitory activity in TNFα, Her3, and IL-2 pathway models. Sec61-IN-2 can be used for cancer research[1].
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Sec61-IN-2 | 99.51% | Sec61-IN-2 is a Sec61 inhibitor. Sec61-IN-2 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC50 = 42 nM), while it has almost no inhibitory activity in TNFα, Her3, and IL-2 pathway models. Sec61-IN-2 can be used for cancer research. | ||||||||||||||||||||
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Keywords
